“…Furthermore, it has been discussed in the literature that soft tissue seal formation around an implant neck is critical to provide a barrier against bacterial penetration toward the bone [ 17 ]. Despite high survival rates, failures of dental implants are expected to increase, as an estimated 500,000 dental implants are placed every year in the USA alone [ 18 , 19 ]. Many factors can influence the survival of an implant, including implant loading procedures, microbial biofilm formation, corrosion, systemic health, and host immune–inflammatory responses [ 20 , 21 , 22 ].…”