Rationale, design, and baseline characteristics of the Cardiovascular Prognostic COUPLING Study in Japan (the COUPLING Registry)

Kario, Kazuomi; Kabutoya, Tomoyuki; Fujiwara, Takeshi; Negishi, Keita; Nishizawa, Masafumi; Yamamoto, Masahiro; Yamagiwa, Kayo; Kawashima, Akitsugu; Yoshida, Tetsuro; Nakazato, Jun; Matsui, Yoshio; Sekizuka, Hiromitsu; Abe, Hideyasu; Abe, Yasuhisa; Fujita, Yumiko; Sato, Kei; Narita, Keisuke; Tsuchiya, Norihiro; Kubota, Yoshiaki; Hashizume, Toshinori

doi:10.1111/jch.13764

Cited by 16 publications

(18 citation statements)

References 34 publications

(43 reference statements)

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“…The HOPE Asia Network has published a number of papers on important Asia‐specific topics in hypertension . This Asia‐specific issue of the Journal of Clinical Hypertension provides an important resource including original research and review articles on the management of hypertension from a variety of Asian viewpoints, including topics such as central BP, environmental factors, comorbidities such as diabetes, atrial fibrillation, heart failure, and dementia, recent Asian guidelines and so forth . This issue also includes reports from twelve countries/regions in Asia to help define and highlight the current status of hypertension, its management, and their initiatives.…”

Section: Resultsmentioning

confidence: 99%

The HOPE Asia Network activity for “zero” cardiovascular events in Asia: Overview 2020

Kario

2020

J of Clinical Hypertension

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The impact of hypertension-related cardiovascular disease and target organ damage, and therefore the benefits of blood pressure (BP) control, is greater in Asian than in Western countries. Asia-specific features of hypertension and its effective management are important and active areas of research. The Hypertension Cardiovascular Outcome Prevention and Evidence in Asia (HOPE Asia) Network was formed in 2016and is now a member of the World Hypertension League. The main goal of the HOPE Asia Network is to improve the management of hypertension and organ protection toward achieving "zero" cardiovascular events in Asia. Considerable work has already been done on the journey to achieving this goal. We have shown that BP control status in Asia differs between countries, and even between regions within the same country. Several expert panel consensus recommendations and clinical guidance papers are available to support the use of home and ambulatory BP monitoring in the region. In addition, the AsiaBP@Home study prospectively investigated home BP control status across 15 specialist centers using the same validated device and measurement schedule. We have also proposed the concept of systemic hemodynamic atherothrombotic syndrome (SHATS), a vicious cycle of BP variability and vascular disease on cardiovascular events and organ damage, and suggested a SHATS score for risk stratification for clinical practice. This special issue of the journal collates Asia-specific resources and data, contributing to advances in hypertension management and cardiovascular disease prevention in the region.

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Section: Resultsmentioning

confidence: 99%

The HOPE Asia Network activity for “zero” cardiovascular events in Asia: Overview 2020

Kario

2020

J of Clinical Hypertension

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“…Additionally, it has been reported that CAVI ≥ 9.0 predicted higher cardiovascular events in diabetic patients (34). On the other hand, the associations between changes of CAVI and prognosis have not yet been examined (35). A prospective, large-scale, and longitudinal study with repeated measurement of CAVI in high cardiovascular risk patients, the Coupling registry, has been under way (35).…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the associations between changes of CAVI and prognosis have not yet been examined (35). A prospective, large-scale, and longitudinal study with repeated measurement of CAVI in high cardiovascular risk patients, the Coupling registry, has been under way (35). The study may provide useful information on the significance of both baseline CAVI and changes in CAVI over time as indicators of cardiovascular prognosis (35).…”

Section: Discussionmentioning

confidence: 99%

Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure

Watanabe

Yoshihisa

Sato

et al. 2021

Front. Cardiovasc. Med.

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Aims: We aimed to assess the associations of CAVI with exercise capacity in heart failure (HF) patients. In addition, we further examined their prognosis.Methods: We collected the clinical data of 223 patients who had been hospitalized for decompensated HF and had undergone both CAVI and cardiopulmonary exercise testing.Results: For the prediction of an impaired peak oxygen uptake (VO2) of < 14 mL/kg/min, receiver-operating characteristic curve demonstrated that the cutoff value of CAVI was 8.9. In the multivariate logistic regression analysis for predicting impaired peak VO2, high CAVI was found to be an independent factor (odds ratio 2.343, P = 0.045). We divided these patients based on CAVI: the low-CAVI group (CAVI < 8.9, n = 145) and the high-CAVI group (CAVI ≥ 8.9, n = 78). Patient characteristics and post-discharge cardiac events were compared between the two groups. The high-CAVI group was older (69.0 vs. 58.0 years old, P < 0.001) and had lower body mass index (23.0 vs. 24.1 kg/m2, P = 0.013). During the post-discharge follow-up period of median 1,623 days, 58 cardiac events occurred. The Kaplan–Meier analysis demonstrated that the cardiac event rate was higher in the high-CAVI group than in the low-CAVI group (log–rank P = 0.004). The multivariate Cox proportional hazard analysis revealed that high CAVI was an independent predictor of cardiac events (hazard ratio 1.845, P = 0.035).Conclusion: High CAVI is independently associated with impaired exercise capacity and a high cardiac event rate in HF patients.

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“…The results of our single‐arm study did not show any favorable effect of luseogliflozin on arterial stiffness, measured using the cardio‐ankle vascular index (CAVI) 2 . As a measure of arterial stiffness, CAVI is relatively independent of blood pressure (BP) and is now widely used in cardiovascular research and clinical practice 3–7 …”

mentioning

confidence: 85%

“…2 As a measure of arterial stiffness, CAVI is relatively independent of blood pressure (BP) and is now widely used in cardiovascular research and clinical practice. [3][4][5][6][7] SGLT 2 inhibitors were primarily developed as antidiabetic agents, but are also considered as a new class of "antihypertensive drugs" due to their homeostatic mechanisms. These include regulation of body fluid volume by diuretic activity and attenuation of sympathetic nerve-mediated salt sensitivity, which may be closely associated with the cardiorenal protective properties.…”

Section: E T T E R T O T H E E D I T O R -R E S P O N S Ementioning

confidence: 99%

Randomized, “head‐to‐head” studies comparing different SGLT2 inhibitors are definitely needed

Kario

Harada

Hoshide

2020

J of Clinical Hypertension

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Rationale, design, and baseline characteristics of the Cardiovascular Prognostic COUPLING Study in Japan (the COUPLING Registry)

Cited by 16 publications

References 34 publications

The HOPE Asia Network activity for “zero” cardiovascular events in Asia: Overview 2020

The HOPE Asia Network activity for “zero” cardiovascular events in Asia: Overview 2020

Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure

Randomized, “head‐to‐head” studies comparing different SGLT2 inhibitors are definitely needed

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