Rationale and use of near-infrared spectroscopy for detection of lipid-rich and vulnerable plaques

Waxman, Sergio; Ishibashi, Fumlyuki; Caplan, Jay D.

doi:10.1016/j.nuclcard.2007.08.001

Cited by 22 publications

(23 citation statements)

References 47 publications

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“…In fact, one group has already employed these concepts to design a clinically compatible instrument for plaque detection that accesses the SWIR portion of the spectrum. [47][48][49] This example has been successfully translated into a commercial product, the catheter-based TVC Imaging System developed by Infraredx ® , for determining information about the structure and plaque content of blood vessels in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…In fact, it has already been shown that water and lipid absorptions provide useful diagnostic "fingerprints" for detection of both cancer 8,40 and atherosclerosis. 9,14,22,23,[47][48][49] On the path toward a more widespread implementation of SWIR tissue optics measurements, one important factor to consider is the temperature dependence of tissue absorption features in the SWIR regime. Water is a primary SWIR absorber in tissue, and it has been shown 53,54 that the spectral location of SWIR water absorption peaks can vary with temperature.…”

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confidence: 99%

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Review of short-wave infrared spectroscopy and imaging methods for biological tissue characterization

et al. 2015

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

Review of short-wave infrared spectroscopy and imaging methods for biological tissue characterization

et al. 2015

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“…The SWIR regime features absorption from tissue constituents such as water (near 1,150, 1,450, and 1,900 nm), lipids (near 1,040, 1,200, 1,400, and 1,700 nm), and collagen (near 1,200 and 1,500 nm) that are more prominent than corresponding features in the visible and NIR regions (12). The enhanced sensitivity to these chromophores enables better characterization of changes in their concentration, with recent spectroscopy-based examples in detecting and monitoring cancerous tissues (13)(14)(15), burns (3), and intestinal ischemia (16), distinguishing skin bruises from surrounding tissue (17,18), and discriminating histologically vulnerable and stable plaques of blood vessels in vivo (19)(20)(21). In addition, SWIR light offers greater transmission through biological tissue than visible or NIR light due to decreased scattering of photons (9,22,23).…”

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confidence: 99%

Using the shortwave infrared to image middle ear pathologies

Carr

Valdez

Bruns

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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Visualizing structures deep inside opaque biological tissues is one of the central challenges in biomedical imaging. Optical imaging with visible light provides high resolution and sensitivity; however, scattering and absorption of light by tissue limits the imaging depth to superficial features. Imaging with shortwave infrared light (SWIR, 1–2 μm) shares many advantages of visible imaging, but light scattering in tissue is reduced, providing sufficient optical penetration depth to noninvasively interrogate subsurface tissue features. However, the clinical potential of this approach has been largely unexplored because suitable detectors, until recently, have been either unavailable or cost prohibitive. Here, taking advantage of newly available detector technology, we demonstrate the potential of SWIR light to improve diagnostics through the development of a medical otoscope for determining middle ear pathologies. We show that SWIR otoscopy has the potential to provide valuable diagnostic information complementary to that provided by visible pneumotoscopy. We show that in healthy adult human ears, deeper tissue penetration of SWIR light allows better visualization of middle ear structures through the tympanic membrane, including the ossicular chain, promontory, round window niche, and chorda tympani. In addition, we investigate the potential for detection of middle ear fluid, which has significant implications for diagnosing otitis media, the overdiagnosis of which is a primary factor in increased antibiotic resistance. Middle ear fluid shows strong light absorption between 1,400 and 1,550 nm, enabling straightforward fluid detection in a model using the SWIR otoscope. Moreover, our device is easily translatable to the clinic, as the ergonomics, visual output, and operation are similar to a conventional otoscope.

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“…The first clinical analysis with catheter based NIRS was reported by Waxman et al [31]. In their study near infrared spectra were collected in 125 patients with stable and unstable coronary artery disease at the time of percutaneous coronary intervention.…”

Section: Near-infrared Spectroscopymentioning

confidence: 99%

Spectroscopy to improve identification of vulnerable plaques in cardiovascular disease

Bruggink

Meerwaldt

Dam

et al. 2009

Int J Cardiovasc Imaging

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Many apparent healthy persons die from cardiovascular disease, despite major advances in prevention and treatment of cardiovascular disease. Traditional cardiovascular risk factors are able to predict cardiovascular events in the long run, but fail to assess current disease activity or nearby cardiovascular events. There is a clear relation between the occurrence of cardiovascular events and the presence of so-called vulnerable plaques. These vulnerable plaques are characterized by active inflammation, a thin cap and a large lipid pool. Spectroscopy is an optical imaging technique which depicts the interaction between light and tissues, and thereby shows the biochemical composition of tissues. In recent years, impressive advances have been made in spectroscopy technology and intravascular spectroscopy is able to assess the composition of plaques of interest and thereby to identify and actually quantify plaque vulnerability. This review summarizes the current evidence for spectroscopy as a measure of plaque vulnerability and discusses the potential role of intravascular spectroscopic imaging techniques.

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Rationale and use of near-infrared spectroscopy for detection of lipid-rich and vulnerable plaques

Cited by 22 publications

References 47 publications

Review of short-wave infrared spectroscopy and imaging methods for biological tissue characterization

Review of short-wave infrared spectroscopy and imaging methods for biological tissue characterization

Using the shortwave infrared to image middle ear pathologies

Spectroscopy to improve identification of vulnerable plaques in cardiovascular disease

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