Rationale and study design of the OISTER trial: Optical coherence tomography evaluation of stent struts re-endothelialization in patients with non-ST-elevation acute coronary syndromes – a comparison of the intrEpide tRapidil eluting stent vs. taxus drug-eluting stent implantation

Abstract

We hypothesize that the utilization of trapidil-eluting DES in the setting of acute coronary syndromes will be characterized by a greater early re-endothelialization associated with an antiproliferative effect offering a similar efficacy with a better safety profile compared with first-generation DES.

microRNAs Distinctively Regulate Vascular Smooth Muscle and Endothelial Cells: Functional Implications in Angiogenesis, Atherosclerosis, and In-Stent Restenosis

“…A normal operative endothelium is crucial due to its participation in the regulation of vascular tone, alongside with its role in suppressing intimal hyperplasia by inhibiting inflammation, thrombus formation, and VSMC proliferation and migration [2, 141, 142]. Thus, the endothelium provides a selectively permeable barrier that protects against potentially detrimental circulating factors [143–145]. Endothelial denudation and medial wall injury are generally considered the initial effects of angioplasty-induced injury [146–149].…”