Rationale and principle of an instrument measuring lung deposited nanoparticle surface area

In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung—A dialog between aerosol science and biology

“…a scanning mobility particle sizer) and model the subsequent size-dependent lung deposition with computational models (Ferron et al, 1988;Hofmann, 1996) or with standard lung deposition curves as provided by the ICRP software (ICRP, 1994). More recently, an alternative more direct technology has become available, which infers the lung-deposited nanoparticle surface area (between 10 and 400 nm in diameter) by adjusting the size-resolved response function of the instrument so that it corresponds to the lung-deposited particle surface area Asbach et al, 2009;Fissan et al, 2007).…”

Determination of the ratio of diffusion charging-based surface area to geometric surface area for spherical particles in the size range of 100–900nm

“…Jung and Kittelson (2005) also measured the LQ1-DC response to near-spherical NaCl particles and diesel agglomerate particles in the size range from 30 to 150 nm, but found 15% higher response of the DC to the agglomerates compared with NaCl particles. Other commercial diffusion chargers tailored the DC response to the surface area of particles depositing in selected regions of the lungs (Fissan, Neumann, & Trampe, 2007) and thus do not provide information about the geometrical surface area of particles.…”

Determination of mean particle size using the electrical aerosol detector and the condensation particle counter: Comparison with the scanning mobility particle sizer

“…As a relatively new parameter, the relationship of total aerosol length to other particle measurement metrics is not yet well understood and it does not yet fit in well with our conceptual understanding of particle behavior. A good correlation has been found between total aerosol length and model predictions of the penetration of aerosol particles into the respiratory system (Fissan et al, 2007;Wilson et al, 2004).…”

“…The net current measured by the electrometer (taking internal particle losses into account) is proportional to the 1.133 power of the particle diameter (Fissan, Neumann, Trampe, Pui, & Shin, 2007;Johnson et al, 2002). The EAD reports this value as the aerosol diameter concentration, or total aerosol length, in units of mm/cm 3 .…”