Rationale and neurobiological effects of treatment with antipsychotics in patients with chronic schizophrenia considering dopamine supersensitivity

Kimura, Hiroshi; Kanahara, Nobuhisa; Iyo, Masaomi

doi:10.1016/j.bbr.2021.113126

Cited by 11 publications

(17 citation statements)

References 164 publications

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“…A biosensor response to 5 mM interfering substance (glutamate, cysteine, tyrosine, glucose, uric and ascorbic acids) was recorded (Figure 5, A). The results of the experiment indicate that the developed conductomet- 5), tyrosine (6), glucose (7) and arginine (8). The concentration of all analytes 5 mM.…”

Section: Selectivity Of the Biosensormentioning

confidence: 85%

“…According to the "dopamine theory of schizophrenia", the brain of patients with schizophrenia produces more dopamine, which enters the postsynaptic neurons of the brain in the mesolimbic system in the presence of such signs as psychosis, auditory and visual hallucinations, obsessions, whereas the prevalence of true depression, extrapyramidal disorders, catalepsy are characterized by low dopamine level [6,7]. Dopamine is also involved in the development of Parkinson's disease, and role of domine and its receptors in the disease is intensively investigated [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…5. (A) Responses of the dopamine-sensitive conductometric biosensor to dopamine (1), glutamate (2), cysteine (3), ascorbic acid (4), uric acid (5), tyrosine (6), glucose(7) and arginine(8). The concentration of all analytes 5 mM.…”

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confidence: 99%

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Development of Enzyme Conductometric Biosensor for Dopamine Determination in Aqueous Samples

et al. 2021

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Dopamine is a biologically active chemical that performs a number of vital functions as a hormone and neurotransmitter. Therefore, the determination of dopamine concentration in the human body is important for biomedical research. The content of dopamine in the blood varies depending on the age of a healthy person and can serve as a prognostic marker of many diseases. The aim of this work was to develop a new enzyme conductometric biosensor for the determination of dopamine in aqueous samples and to study the biosensor's analytical characteristics. The conductometric method of analysis with differential measurement mode was used in the work. Two pairs of gold interdigitated electrodes deposited on a sitall substrate were used as a conducto-metric transducer. The biorecognition element of the biosensor was based on laccase immobilized by glutaraldehyde cross-linking. The optimal conditions of laccase immobilization were selected. The influence of solution parameters (ionic strength, pH, buffer capacity) on the biosensor work was investigated. The biosensors demonstrated high sensitivity to dopamine (minimum limit of detection À 7.8 μM) with the linear range up to 1 mM. The biosensor was highly selective and reusable. The proposed biosensor was tested regarding the possibility of its longterm storage under different conditions. The developed conductometric biosensor was proven to be suitable for measuring dopamine concentration in biological and pharmaceutical samples.

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Section: Selectivity Of the Biosensormentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Development of Enzyme Conductometric Biosensor for Dopamine Determination in Aqueous Samples

et al. 2021

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“…In this context, the use of an LAI other than aripiprazole oncemonthly is a common strategy. Similarly, some oral antipsychotics with long half-lives such as blonanserin and paliperidone might be beneficial for patients with DSP [4] (Table 1: showing agents with efficacy for DSP [6][7][8][9][10][11][12][13][14][15][16][17][18]). However, both of the present patients showed persistent positive symptoms that were not controlled even by antipsychotic agents with long half-lives.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Asenapine in Drug-resistant Psychotic Patients with Dopamine Supersensitivity Psychosis: Two Cases

Kanahara

Kimura

Kinoshita

et al. 2023

Clin Psychopharmacol Neurosci

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Dopamine supersensitivity psychosis (DSP) is an unstable clinical condition observed in individuals with schizophrenia who have been treated with an antipsychotic medication at a high dosage and/or for a long period. An up-regulation of dopamine D2 receptors (DRD2) is thought to be involved in the essential pathology of DSP. An antipsychotic agent with both tight binding to DRD2 and a long half-life is generally effective for treating DSP, but a patient who meets the criteria of treatment-resistant schizophrenia sometimes needs treatment with clozapine. We report the case details of two patients whose DSP was not controlled with several antipsychotics but was successfully controlled with asenapine. Asenapine binds to a broad range of dopamine receptors and serotonin receptors, and it is thus distinct from other atypical antipsychotics. The unique profile of asenapine may contribute to the control of severe DSP symptoms in individuals with schizophrenia.

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“…The dopamine hypothesis of schizophrenia is the leading and longest standing theory of schizophrenia pathophysiology, stating that characteristic symptoms such as hallucinations, delusions and abnormal cognitive functioning are caused by a synergistic imbalance of dopamine neurotransmission in cortical and subcortical brain regions (Howes & Kapur, 2009;Kimura et al, 2021;Takao et al, 2021). Dopamine system dysregulation can be influenced by both genetic and environmental factors (van Os et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Childhood traumatic events and the dopaminergic theory of psychosis: A mini-review of studies investigating gene – environment interactions

et al. 2021

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There is great body of evidence showing a relationship between childhood adversity and psychosis onset. Genetic factors moderate the association between childhood adversity and psychosis risk potentially by influencing biological and/or psychological reaction following exposure to adversity. In this review, we discuss studies identifying the specific genetic variants known to affect dopamine levels involved in this interaction. Our review shows that the catechol-O-methyltransferase (COMT), dopamine D2 receptor (DRD2), AKT1 gene play a key role in mediating the relationship between childhood adversity and development of psychosis. We have also found conflicting findings on the impact of dopamine genes on the relationship between childhood adversity and development of psychosis, suggesting that other genetic and environmental factors should be taken into account. We here discuss the implications of our findings and future directions.

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Rationale and neurobiological effects of treatment with antipsychotics in patients with chronic schizophrenia considering dopamine supersensitivity

Cited by 11 publications

References 164 publications

Development of Enzyme Conductometric Biosensor for Dopamine Determination in Aqueous Samples

Development of Enzyme Conductometric Biosensor for Dopamine Determination in Aqueous Samples

Efficacy of Asenapine in Drug-resistant Psychotic Patients with Dopamine Supersensitivity Psychosis: Two Cases

Childhood traumatic events and the dopaminergic theory of psychosis: A mini-review of studies investigating gene – environment interactions

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