Rationale and Methodology for a Population-Based Study of Eye Diseases in Malay People: The Singapore Malay Eye Study (SiMES)

Foong, Athena W.P.; Saw, Seang‐Mei; Loo, Jenny Hooi Yin; Shen, Sunny; Loon, Seng-Chee; Rosman, Mohamad; Aung, Tin; Tan, Donald; Tai, E. Shyong; Wong, Tien Yin

doi:10.1080/09286580600878844

Cited by 411 publications

(357 citation statements)

References 52 publications

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“…The methodology has been published elsewhere. 14 The sampling frame consisted of all Malays aged 40-79, living in designated study areas in southwestern Singapore. From a list of 16 069 names provided by the Ministry of Home Affairs, age-stratified random sampling was used to select 5600 names (1400 people from each decade of 40-49, 50-59, 60-69, 70-79 years).…”

Section: Study Populationmentioning

confidence: 99%

“…The participants (n ¼ 3280) and non-participants (n ¼ 888) did not differ in their gender composition (P ¼ 0.821), but there were significantly greater proportions of older-aged people among the non-participants (Po0.001), as reported previously. 14 An interviewer-administered questionnaire was used to collect socioeconomic and medical information. Data collected include country of birth, marital status, education, occupation, current housing status, as well as lifestyle factors (past and present smoking), eye symptoms, systemic medical, surgical history, etc.…”

Section: Study Populationmentioning

confidence: 99%

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Impact of symptomatic dry eye on vision-related daily activities: The Singapore Malay Eye Study

Tong

Waduthantri

Wong

et al. 2010

Eye

102

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Purpose To examine the impact of symptomatic dry eye on vision-related daily activities. Methods A population-based survey of eye diseases was conducted on 3280 (78.7% response rate) Malay persons aged X40 years, who were randomly selected from designated areas in southwestern Singapore. Participants were administered a standardized dry eye questionnaire consisting of six questions on symptoms, a questionnaire on vision-related daily activities, and underwent a comprehensive systemic and ocular examination. Symptomatic dry eye was defined as one or more self-reported symptoms that were frequently present (ranked as often or all the time). Logistic regression method was used to examine the relationship of symptomatic dry eye with difficulty in performing daily activities. Results In adults without visual impairment, symptomatic dry eye after adjusting for age, gender, and presenting visual acuity was significantly associated with difficulty in vision-related activities such as navigating stairs (odds ratio (OR) ¼ 1.96, 95% confidence interval (CI): 1.28-3.00), recognizing friends (OR ¼ 1.99, 95% CI: 1.45-2.73), reading road signs (OR ¼ 1.87, 95% CI: 1.36-2.57), reading newspaper (OR ¼ 1.50, 95% CI: 1.11-2.04), watching television (OR ¼ 1.90, 95% CI: 1.26-2.87), cooking (OR ¼ 1.94, 95% CI: 1.02-3.71), and driving at night (OR ¼ 2.06, 95% CI: 1.32-3.21). Conclusion Symptomatic dry eye was associated with difficulty in performing vision-dependent tasks, independent of visual acuity and other factors. These findings have public health significance and suggest that the visual dysfunction in dry eye should be further characterized.

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Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Impact of symptomatic dry eye on vision-related daily activities: The Singapore Malay Eye Study

Tong

Waduthantri

Wong

et al. 2010

Eye

102

View full text Add to dashboard Cite

show abstract

“…The study design and detailed methodology are described elsewhere. 12,13 Tenets of the Declaration of Helsinki were followed and approval was granted from the institutional review board of (IRB) the Singapore Eye Research Institute (SERI). Written informed consent was obtained from all participants.…”

Section: Study Populationmentioning

confidence: 99%

Quantitative retinal vascular calibre changes in diabetes and retinopathy: the Singapore Malay eye study

Islam

Nguyen

Wang

et al. 2008

Eye

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Purpose To describe the relationship of retinal vascular calibre with diabetes and diabetic retinopathy in an Asian population. Methods A total of 3280 (78.7% response) subjects, aged 40-80 years, of Malay ethnicity residing in Singapore participated in this population-based, cross-sectional study. Retinal vascular calibre was measured and summarized using a validated computer programme from digital retinal photographs. Diabetic retinopathy signs were graded from photographs using the modified Airlie House classification. Results Of the 3004 subjects with data for this analysis, 682 (22.7%) had diabetes, of whom 194 (28.4%) had retinopathy. After multivariable adjustment, retinal arteriolar calibre was significantly wider in persons with diabetes (141 vs 139 lm, Po0.001); venular calibre was not associated with diabetes (P ¼ 0.93). Among participants with diabetes, venular calibre increased from 218.7 lm in those without retinopathy to 231.1 lm in those with moderate and 231.4 lm in those with severe retinopathy (P for trend ¼ o0.001); arteriolar calibre was not associated with diabetic retinopathy. Conclusions This study shows wider retinal arterioles in diabetes and wider venules in those with diabetic retinopathy in an Asian population. These findings confirm earlier data on white population, supporting the concept that a quantitative assessment of retinal vasculature may provide further insights into early diabetic microvascular damage.

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“…Details of the population selection and study methods have been published previously. 25,26 SP2 is a population-based cross-sectional study of participants aged X24 years (age range in the current study ¼ 24 --79 years) living in Singapore. Of the 7742 eligible participants, 5157 attended the health examination.…”

Section: Methodsmentioning

confidence: 99%

“…26 Of the 3106 participants with CRP and BP measurements, after excluding those with hypertension (n ¼ 2131), those with missing information on variables included in the multivariable model (n ¼ 17) and those with CRP levels 4100 mg l À1 (n ¼ 1), 957 were included in the final analysis.…”

Section: Methodsmentioning

confidence: 99%

Serum C-reactive protein level and prehypertension in two Asian populations

et al. 2012

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Rationale and Methodology for a Population-Based Study of Eye Diseases in Malay People: The Singapore Malay Eye Study (SiMES)

Abstract: This study provides population-based data on the prevalence of and risk factors for age-related eye diseases in people of Malay ethnicity in Singapore. Data from this study allow further understanding of the etiology and impact of eye diseases in this ethnic group.

Cited by 411 publications

References 52 publications

Impact of symptomatic dry eye on vision-related daily activities: The Singapore Malay Eye Study

Impact of symptomatic dry eye on vision-related daily activities: The Singapore Malay Eye Study

Quantitative retinal vascular calibre changes in diabetes and retinopathy: the Singapore Malay eye study

Serum C-reactive protein level and prehypertension in two Asian populations

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