Rationale and design of the African Cardiomyopathy and Myocarditis Registry Program: The IMHOTEP study

Kraus, Sarah; Shaboodien, Gasnat; Francis, Veronica; Laing, Nakita; Cirota, Jacqui; Chin, Ashley; Pandie, Shaheen; Lawrenson, John; Gam., Comitis; Fourie, Barend; Zühlke, Liesl; Wonkam, Ambroise; Wainwright, Helen; Damasceno, Albertino; Mocumbi, Ana Olga; Pepeta, Lungile; Moeketsi, Khulile; Thomas, Baby; Thomas, Kandathil; Makotoko, M.; Brown, Stephen C.; Ntsekhe, Mpiko; Sliwa, Karen; Badri, Motasim; Gumedze, Freedom; Cordell, Heather J.; Keavney, Bernard; Ferreira, Vanessa M.; Mahmod, Masliza; Cooper, Leslie T.; Yacoub, Magdi H.; Neubauer, Stefan; Watkins, Hugh; Mayosi, Bongani M.; Ntusi, Ntobeko

doi:10.1016/j.ijcard.2021.02.026

Cited by 8 publications

(2 citation statements)

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“…Groote Schuur Hospital (GSH) is a tertiary academic hospital affiliated to the University of Cape Town (UCT) and is a referral centre for patients with cardiomyopathy. 7 At time of diagnosis, all consecutive, consenting patients with PPCM are enrolled to a dedicated PPCM registry, and return for regular outpatient follow-up visits. 8 In this prospective, single-centre study, we invited all patients who attended their scheduled out-patient follow-up appointments to take part in this sub-study on drug adherence (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

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Adherence to heart failure treatment in patients with peripartum cardiomyopathy

Hoevelmann,

Sliwa,

Schaar

et al. 2024

ESC Heart Failure

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AimsPeripartum cardiomyopathy (PPCM) is characterized by left ventricular (LV) dysfunction developing towards the end of pregnancy or in the first months postpartum. Although about 60% of women with PPCM (the majority of which are prescribed evidence based heart failure [HF] medications) show LV recovery within 6 to 12 months, others remain with persistently impaired LV function. Poor adherence to medical therapy represents a major cause of avoidable hospitalizations, disability, and death in other cardiovascular conditions. In this study, we aimed to determine drug adherence to HF therapy among women with PPCM and to identify possible associations between drug adherence and LV recovery, functional status and psychological well‐being.Methods and resultsIn this single‐centre, prospective, observational study, we included 36 consecutive women with PPCM. Adherence to HF treatment was assessed by (i) verifying the collection of pharmacy refills and (ii) using liquid chromatography high‐resolution mass spectrometry (LC‐HRMS). Participants were thereby classified as ‘adherent’ (i.e. all prescribed HF drugs were detectable by LC‐HRMS), ‘partially adherent’ (i.e. at least one prescribed drug detectable) or ‘non‐adherent’ (i.e. none of the prescribed drugs detectable). Health state index scores were assessed by EQ‐5D‐5L and HADS‐A/D (for anxiety/depression). Patients' median age was 32.4 years (IQR 27.6–36.1). At the adherence visit (which occurred at a median of 16 months [IQR 5–45] after PPCM diagnosis), prescription included beta‐blockers (77.8%), angiotensin‐converting enzyme inhibitors/angiotensin II receptor blockers (75%), mineralocorticoid receptor antagonists (47.2%) and loop diuretics (95.2%). Less than two thirds of patients (63.9%) collected all their pharmacy refills in the 6 months prior to adherence visit. According to LC‐HRMS, 23.5% participants were classified as adherent, 53.0% as partially adherent, and 23.5% as non‐adherent. Adherence was associated with significantly lower LVEDD at follow‐up (47 mm [IQR 46–52), vs. 56 mm [IQR 49–64] with partial adherence, and 62 mm [IQR 55–64] with non‐adherence, P = 0.022), and higher LVEF at follow‐up (60% [IQR 41–65]), vs. partially adherence (46% [IQR 34–50]) and non‐adherence (41.0% [IQR 29–47], P = 014). Adherent patients had a lower overall EQ‐ 5D score (5.5 [IQR 5–7.5], vs. 6 [IQR 5–7] in partially adherent, and 10 [IQR 8–15] in non‐adherent patients, P = 0.032) suggestive of a better self‐rated health status.ConclusionsAdherence to HF therapy was associated with favourable LV reverse remodelling in PPCM and better self‐rated health status. Our study highlights the importance of drug adherence for functional recovery. Drug adherence should be an important component of patient communication and specific interventions in PPCM.

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Section: Methodsmentioning

confidence: 99%

“…Groote Schuur Hospital (GSH) is a tertiary academic hospital affiliated to the University of Cape Town (UCT) and is a referral centre for patients with cardiomyopathy 7 . At time of diagnosis, all consecutive, consenting patients with PPCM are enrolled to a dedicated PPCM registry, and return for regular outpatient follow‐up visits 8 .…”

Section: Methodsmentioning

confidence: 99%

Adherence to heart failure treatment in patients with peripartum cardiomyopathy

Hoevelmann,

Sliwa,

Schaar

et al. 2024

ESC Heart Failure

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The genetic basis for adult-onset idiopathic dilated cardiomyopathy in people of African descent

et al. 2023

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Cardiomyopathies are a heterogeneous group of cardiac muscle disorders that result in dilated, hypertrophic, or restrictive pathophysiological entities. Dilated cardiomyopathy (DCM) is the most common form in sub-Saharan Africa (SSA). However, population-specific research studies reporting the actual burden of DCM in this region are still lacking. Also, little is known about the genetic basis of DCM in this population, and genetic testing is still not readily accessible. This review describes the common pathogenic genes implicated in DCM globally and discusses the evidence-based management of patients with DCM. We also present a summary of studies describing genes implicated or associated with DCM in patients residing in SSA.

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