Rationale and design of POPular-TAVI: antiPlatelet therapy fOr Patients undergoing Transcatheter Aortic Valve Implantation

Comparison of single versus dual antiplatelet therapy after TAVR: A systematic review and meta‐analysis

“…An ongoing large randomized study, POPULAR‐TAVI (cohort A) [NCT02247128] comparing DAPT with ASA and clopidogrel versus clopidogrel alone will throw further light on optimal management of patients after TAVR . In the lack of definitive evidence, whether an OAC based approach is superior to SAPT or DAPT in patients otherwise without an indication for anti‐coagulation remains unanswered.…”

Antithrombotic therapy in patients undergoing transcatheter aortic valve implantation

“…In the Aspirin Versus Aspirin+ClopidogRel Following TAVI trial, randomisation to DAPT versus SAPT in 222 patients resulted in an increased risk of major or life-threatening bleeding events but no differences in the rate of myocardial infarction or stroke 14. The ongoing APT fOr Patients Undergoing TAVI trial (NCT02247128) is testing the safety and efficacy of SAPT versus DAPT and OAC+clopidogrel versus OAC monotherapy 15. The ongoing safety profile evaluation of TICagrelor Alone compared with a Combination of Lysine Acetylsalicylate-Clopidogrel in the Context of TAVI trial (NCT02817789) will test the 30-day safety profile of SAPT using ticagrelor.…”

Systemic Inflammation after Transcatheter Aortic Valve Implantation: A Prospective Exploratory Study

“…The patients included in this study also took part in the randomized controlled Antiplatelet Therapy for Patients Undergoing Transcatheter Aortic Valve Implantation (POPular-TAVI) trial (ClinicalTrials.gov Identifier NCT02247128). 4 SIRS was defined as the development of 2 or more of the following symptoms during the first 48 hours after TAVI and that lasted for 1 hour or more: leukocyte count 412 or o4 (10 9 /L), respiratory rate 4 20 breaths/minute or PaCO 2 o32 mmHg, temperature o 36.0 or 4 38.01C, heart rate 4 90 beats/minute. 5 The SIRS criteria respiratory rate and PaCO 2 were not assessed if a patient was mechanically ventilated.…”

“…1,2 Complications such as breakage of the catheter have been described with the epidural technique but are very rare in the case of paravertebral blocks. [3][4][5][6] A 62-year-old female patient underwent a right lower lobectomy through a videothoracoscopic posterior approach with a conversion to a posterolateral muscle-sparing thoracotomy with rib spreading as a result of technical difficulties. At the end of the surgery, the operating surgeon inserted a paravertebral catheter under direct vision.…”