Rational vaccinology with spherical nucleic acids

Wang, Shuya; Qin, Lei; Yamankurt, Gokay; Skakuj, Kacper; Huang, Ziyin; Chen, Peng Cheng; Dominguez, Donye; Lee, Andrew; Zhang, Bin; Mirkin, Chad A.

doi:10.1073/pnas.1902805116

Cited by 86 publications

(144 citation statements)

References 42 publications

Supporting

Mentioning

139

Contrasting

Order By: Relevance

“…Figure 3a, b highlights some nanotechnologies used in subunit vaccine design. Besides the aforementioned antigen multivalency, nanocarriers enable efficient co-delivery of antigen/ adjuvant to secondary lymphoid organs 59 , exhibit size-dependent lymphatic trafficking and preferential uptake by antigen presenting cells (APCs), create depot effects for sustained immune stimulus, and facilitate antigen cross presentation-enabling extracellular antigens to be presented via the MHC-I pathway for CD8 + T cell engagement 60 (Fig. 3c).…”

Section: Review Article | Focusmentioning

confidence: 99%

COVID-19 vaccine development and a potential nanomaterial path forward

et al. 2020

View full text Add to dashboard Cite

, a novel coronavirus (nCoV or SARS-CoV-2) belonging to the betacoronavirus family emerged 1,2. All human betacoronaviruses are unique from one another, however, they do share a certain degree of genetic and structural homology. SARS-CoV-2 genome sequence homology with SARS-CoV and MERS-CoV is 77% and 50%, respectively 3. In contrast to the relatively smaller outbreaks of SARS-CoV in 2002 and MERS-CoV in 2012, SARS-CoV-2 is exhibiting an unprecedented scale of infection, resulting in a global pandemic declaration of Coronavirus Infectious Disease (COVID-19) on 11 March 2020 by the World Health Organization (WHO). On 1 June 2020, the World Health Organization reported >6 million confirmed cases and 371 thousand deaths globally. Of note, during the 1918 influenza pandemic, more death was observed in the second phase of outbreak 4. Similar to influenza, COVID-19 harbours the potential to become a seasonal disease 5. The high infection rate, long incubation period, along with mild-to-moderate symptoms experienced by many, make COVID-19 a troubling disease. A vaccine is crucial, in particular because data indicate asymptomatic transmission of COVID-19 6-8. More than 10 years ago, scientists predicted the pandemic potential of the coronaviruses 9. And for the past 30 years, a once-per-decade novel coronavirus has pushed our public health system to the limit, with SARS-CoV-2 being the most severe. Despite the repeated warnings and discussion, the world was not prepared for this pandemic. The rapid development, distribution and administration of a vaccine to the global population is the most effective approach to quell this pandemic and the only one that will lead to a complete lifting of restrictions. Challenges include the vaccine design itself, but also its manufacture and global distribution; cold chain requirements present logistical and fiscal barriers to the availability of important, life-saving vaccines in resource-poor areas of the world. Innovating vaccine delivery platforms and devices to break cold chain limitations are therefore an efficient solution to safeguard potent vaccination for both wealthy and lower-income countries.

show abstract

Section: Review Article | Focusmentioning

confidence: 99%

COVID-19 vaccine development and a potential nanomaterial path forward

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The use of biomaterials to study the role of antigen conformation and the form of delivery is not limited to infectious disease. In cancer for example, spherical nucleic acid NPs have been investigated to study how the form of antigen delivery impacts uptake, display, and the resulting antitumor immune response . Likewise, other classes of materials have been used to control antigens that self‐assemble into distinct structures, such as nanofibers .…”

Section: Biomaterials Provide Control Over the Molecular Properties Omentioning

confidence: 99%

Biomaterials as Tools to Decode Immunity

Eppler¹,

Jewell

2019

Advanced Materials

View full text Add to dashboard Cite

The immune system has remarkable capabilities to combat disease with exquisite selectivity. This feature has enabled vaccines that provide protection for decades and, more recently, advances in immunotherapies that can cure some cancers. Greater control over how immune signals are presented, delivered, and processed will help drive even more powerful options that are also safe. Such advances will be underpinned by new tools that probe how immune signals are integrated by immune cells and tissues. Biomaterials are valuable resources to support this goal, offering robust, tunable properties. The growing role of biomaterials as tools to dissect immune function in fundamental and translational contexts is highlighted. These technologies can serve as tools to understand the immune system across molecular, cellular, and tissue length scales. A common theme is exploiting biomaterial features to rationally direct how specific immune cells or organs encounter a signal. This precision strategy, enabled by distinct material properties, allows isolation of immunological parameters or processes in a way that is challenging with conventional approaches. The utility of these capabilities is demonstrated through examples in vaccines for infectious disease and cancer immunotherapy, as well as settings of immune regulation that include autoimmunity and transplantation.

show abstract

“…As a result, DNA brick nanostructures offer a promising alternative to DNA origami. Furthermore, unlike spherical nucleic acids in which DNA strands are coated in an isotropic manner, these DNA brick nanostructures can become asymmetrically functionalized with precise location control, which will have important implications as research efforts shift to the use of multi‐functionalized nanomaterials …”

Section: Figurementioning

confidence: 99%

Enhancing Biocompatible Stability of DNA Nanostructures Using Dendritic Oligonucleotides and Brick Motifs

Kim

Yin

2019

Angewandte Chemie

View full text Add to dashboard Cite

The use of DNA‐based nanomaterials in biomedical applications is continuing to grow, yet more emphasis is being put on the need for guaranteed structural stability of DNA nanostructures in physiological conditions. Various methods have been developed to stabilize DNA origami against low concentrations of divalent cations and the presence of nucleases. However, existing strategies typically require the complete encapsulation of nanostructures, which makes accessing the encased DNA strands difficult, or chemical modification, such as covalent crosslinking of DNA strands. We present a stabilization method involving the synthesis of DNA brick nanostructures with dendritic oligonucleotides attached to the outer surface. We find that nanostructures assembled from DNA brick motifs remain stable against denaturation without any chemical modifications. Furthermore, densely coating the outer surface of DNA brick nanostructures with dendritic oligonucleotides prevents nuclease digestion.

show abstract

Rational vaccinology with spherical nucleic acids

Cited by 86 publications

References 42 publications

COVID-19 vaccine development and a potential nanomaterial path forward

COVID-19 vaccine development and a potential nanomaterial path forward

Biomaterials as Tools to Decode Immunity

Enhancing Biocompatible Stability of DNA Nanostructures Using Dendritic Oligonucleotides and Brick Motifs

Contact Info

Product

Resources

About