Rational Synthesis of Biobased Hyperbranched Poly(ester)s for Sustained Delivery

Polyesters Inspired by Glycerides: Enzymatic Polycondensation, Structure, Properties, and Nanoparticle Preparation

“…Poly­(glycerol adipate) and its derivatives functionalized with fatty acid are one of the most studied glyceride-like polyester used for the preparation of nanoparticles. The control of the degree of acylation and the size of the fatty acid allows tuning the size, morphology, and zeta potential of the nanoparticles as well as the load/release behavior of hydrophobic and hydrophilic molecules into/from the nanoparticles. ,− An interesting work on the capability of the self-assembly of poly­(glycerol sebacate) in nanoparticles and of the loading and releasing of hydrophobic anticancer drugs was reported by Louage et al These aqueous nanoparticle dispersions at 5 mg mL –1 are not cytotoxic for the human ovarian cancer cell line (SKOV-3, in vitro MTT assay) and when loaded with the anticancer drug Paclitaxel at 0.5 mg mL –1 , they are capable of decreasing the cell viability of cancer cells with IC 50 of 13 nM, significantly lower than the IC 50 of commercially available formulations Abraxane and Genexol-PM, 67 and 35 nM, respectively, at an equal Paclitaxel dose …”