Rational investigations in irritable bowel syndrome

Black, Christopher J; Ford, Alexander C

doi:10.1136/flgastro-2019-101211

Cited by 18 publications

(24 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is therefore vital that management is evidencebased to minimise costs and to limit unnecessary use of healthcare resources, such as restricting the use of extensive clinical investigations that are rarely indicated. 162 However, current evidence has a Western bias and there is consequently a need for further studies that address gaps in our understanding of how IBS pathophysiology and treatment responses might differ between countries. Some of the key research priorities in IBS are detailed in Table 2.…”

Section: [H1] Predictions and Future Implicationsmentioning

confidence: 99%

Global burden of irritable bowel syndrome: trends, predictions and risk factors

Black

Ford

2020

Nat Rev Gastroenterol Hepatol

323

237

View full text Add to dashboard Cite

Irritable bowel syndrome (IBS) is one of the most common disorders of gut-brain interaction worldwide and is defined according to patterns of gastrointestinal symptoms, as described by the Rome diagnostic criteria. However, these criteria, developed with reference to research conducted largely in Western populations, might be limited in their applicability to other countries and cultures. Epidemiological data show a wide variation in the prevalence of IBS globally and more rigorous studies are needed to accurately determine any differences that might exist between countries and potential explanations. The effect of IBS on the individual, in terms of their quality of life, and on healthcare delivery and society, in terms of economic costs, is considerable. Although the magnitude of these effects seems to be comparable between nations, their precise nature can vary based on the existence of societal and cultural differences. The pathophysiology of IBS is complex and incompletely understood; genetics, diet and the gut microbiome are all recognised risk factors, but the part they play might be influenced by geography and culture, and hence their relative importance might vary between countries. This Review aims to provide an overview of the burden of IBS in a global context, to discuss future implications for the care of people with IBS worldwide, and to identify key areas for further research.

show abstract

Section: [H1] Predictions and Future Implicationsmentioning

confidence: 99%

Global burden of irritable bowel syndrome: trends, predictions and risk factors

Black

Ford

2020

Nat Rev Gastroenterol Hepatol

323

237

View full text Add to dashboard Cite

show abstract

“…Although IBS has traditionally been considered a diagnosis of exclusion, 60 it is now recommended that a positive diagnosis of IBS should be made proactively and safely provided that patients do not display any "red flag" symptoms. 16,19,61 However, it can be posited that a transition from a negative to a positive approach toward diagnosis is conditional on clinicians being able to adequately communicate with patients and obtain a comprehensive history.…”

Section: Under S Tanding the P Otential Impac T Of R Acial D Is Paritie S On Patient Outcome Smentioning

confidence: 99%

“…[16][17][18] As with other DGBIs, it cannot be diagnosed using a single blood or endoscopic test as it does not possess the traditional investigative markers of what would be classically called a purely "organic illness". 19 For the most part, it is characterized by the presence of symptoms including abdominal pain and change to stool frequency and or form in the absence of any other organic gastrointestinal cause, 16 defined by the Rome IV diagnostic criteria. 20 IBS is a common condition.…”

mentioning

confidence: 99%

Understanding racial disparities in the care of patients with irritable bowel syndrome: The need for a unified approach

Sasegbon

Vasant

2021

Neurogastroenterology Motil

View full text Add to dashboard Cite

The study by Silvernale et al 1 in this issue of Neurogastroenterology & Motility has provided an important insight into racial disparities in the care of patients with irritable bowel syndrome (IBS). Following critical events over the past 12 months, this comes at a time where there is a heightened global awareness of the need to address inherent racial disparities within society brought to the forefront by the death of George Floyd in the United States (US) and the subsequent Black Lives Matter movement. The term racial disparity is used in this context, rather than the term racial difference, as the implication is that some observed differences in society as whole or in health care more specifically are caused by underlying inequity. With regards to healthcare provision and patient outcomes, these racial disparities have been

show abstract

“…The aetiology of irritable bowel syndrome is still unclear. However, many factors have been suggested including genetics, visceral hypersensitivity, disordered gastrointestinal motility, abnormalities of the brain-gut axis, and alterations in the gut microbiome [18]. Additionally, lifestyle factors such as diet [19], alcohol consumption [20] and physical activity [21] have been linked to IBS.…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Irritable bowel syndrome - risk factors, pathogenesis and treatment options

Wójcik

Dąbrowska

Szarpak

et al. 2020

J Educ Health Sport

View full text Add to dashboard Cite

Introduction: Irritable bowel syndrome (IBS) is a chronic common gastrointestinal disorder. It contributes to the burden of patients and society due to direct medical costs, lost productivity and also affects the quality of life. The etiology of irritable bowel syndrome is not fully understood which makes it difficult to treat patients more effectively. The aim of the study: The purpose of this systemic review was to collect and analyse current data of risk factors, pathogenesis and treatment options of irritable bowel syndrome. articles in the PubMed and Google Scholar database was carried out using the following keywords: irritable bowel syndrome, gut microbiota, treatment Description of the state of knowledge: Altered gastrointestinal motility, visceral hypersensitivity, post infectious reactivity, brain-gut interactions, alteration in fecal microflora, bacterial overgrowth, food sensitivity, carbohydrate malabsorption, and intestinal inflammation are considered to contribute to the onset of IBS. The biopsychosocial model of illness and disease aims to help understand better the bi-directional relationship between mind and body. Patients suffering from IBS use pharmaceutical treatment but also complementary and alternative medicine. Probiotic and fecal microbiota transplantation are gut microbiota oriented treatment options. Summary: The pathophysiology of IBS is not clear. Alterations in bidirectional brain-gut microbiota interactions are believed to be involved in the pathogenesis of well-known braingut disorders such as IBS. Human microbiome research continues to expand, although it still requires more study.

show abstract

Rational investigations in irritable bowel syndrome

Cited by 18 publications

References 66 publications

Global burden of irritable bowel syndrome: trends, predictions and risk factors

Global burden of irritable bowel syndrome: trends, predictions and risk factors

Understanding racial disparities in the care of patients with irritable bowel syndrome: The need for a unified approach

Irritable bowel syndrome - risk factors, pathogenesis and treatment options

Contact Info

Product

Resources

About