Rational Fabrication and Biomedical Application of Biomolecule‐Conjugated AIEgens through Click Reaction

Yuan, Qiming; Cheng, Yong; Lou, Xiaoding; Xia, Fan

doi:10.1002/cjoc.201900211

Cited by 13 publications

(12 citation statements)

References 93 publications

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“…This feature is beneficial for fluorescence imaging in bio‐system. [ 28‐39 ] However, only a few organic probes have been developed for H 2 O 2 detection with AIE characteristic, and most of them still suffered from short wavelength emission (< 650 nm). [ 40‐44 ]…”

Section: Background and Originality Contentmentioning

confidence: 99%

Near‐Infrared Fluorescent Nanoprobe for Detecting Hydrogen Peroxide in Inflammation and Ischemic Kidney Injury

Sun

Zeng

et al. 2020

Chin. J. Chem.

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of main observation and conclusion In-situ overexpressed hydrogen peroxide could serve as a biomarker for inflammation and ischemic kidney injury. Herein, a nanoprobe was developed for assay of hydrogen peroxide. The nanoprobe (TA-TPABQ) was formed via the boronate ester groups between the hydrophilic tannic acid and the boric-acid-containing compound (TPABQ) as well as the hydrophobic interactions. The probe with good photostability shows good sensitivity and selectivity towards H2O2. The probe was adopted for identifying endogenous and exogenous H2O2 in living cells. Moreover, the probe was utilized for in vivo imaging experiments in acute abdomina and ankle inflammation mouse models as well as acute renal ischemia mouse model.

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Section: Background and Originality Contentmentioning

confidence: 99%

Near‐Infrared Fluorescent Nanoprobe for Detecting Hydrogen Peroxide in Inflammation and Ischemic Kidney Injury

Sun

Zeng

et al. 2020

Chin. J. Chem.

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“…The amphiphilic polymer skeleton was developed based on poly (ethylene glycol)-b-poly(5-mthyl-5-propargyl-1,3-dioxan-2-one)-g-paclitaxel (PMP), which conjugated with PTX via disulfide linker to obtain a reduction-sensitive polymeric prodrug. Driven by electrostatic interactions, the negative charge of siRNA and positively charged Py-TPE were incorporated into Py-TPE/siRNA@PMP for image-guided gene delivery 23 , 24 . As shown in Scheme 1 , Py-TPE/siRNA@PMP NPs were prepared via self-assembly and able to afford long-lasting circulation in the blood stream.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible AIEgen/p-glycoprotein siRNA@reduction-sensitive paclitaxel polymeric prodrug nanoparticles for overcoming chemotherapy resistance in ovarian cancer

Wu¹,

Wang²,

Dong³

et al. 2021

Theranostics

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Nanoparticle drug delivery system (NDDS) is quite different from the widely studied traditional chemotherapy which suffers from drug resistance and side effect. NDDS offers the straightforward solution to the chemotherapy problem and provides an opportunity to monitor the drug delivery process in real time. In this vein, we developed one NDDS, namely Py-TPE/siRNA@PMP, to relieve resistance and side effects during chemotherapy against ovarian cancer. The Py-TPE/siRNA@PMP is a multifunctional polymeric nanoparticle contained several parts as follows: (1) a nanoparticle (NP) self-assembled by reduction-sensitive paclitaxel polymeric prodrug (PMP); (2) the glutathione (GSH)-responsive release of paclitaxel (PTX) for the suppression of ovarian cancer cells; (3) the P-glycoprotein (P-gp) siRNA for restoring the sensitivity of chemo-resistant tumor cells to chemotherapy; (4) the positively charged aggregation-induced emission fluorogen (AIEgen) Py-TPE for tumor imaging and promoting encapsulation of siRNA into the nanoparticle. Methods : The Py-TPE/siRNA@PMP nanoparticles were prepared by self-assembly method and characterized by the UV-Vis absorption spectra, zeta potentials, TEM image, stability assay and hydrodynamic size distributions. The combinational therapeutic effects of Py-TPE/siRNA@PMP on overcoming chemotherapy resistance were explored both in vitro and in vivo. Result : The Py-TPE/siRNA@PMP exhibited an average hydrodynamic size with a good stability. Meanwhile they gave rise to the remarkable chemotoxicity performances in vitro and suppressed the tumors growth in both SKOV-3/PTX (PTX resistance) subcutaneous and intraperitoneal metastasis tumor models. The investigations on ovarian cancer patient-derived xenografts (PDX) model revealed that Py-TPE/siRNA@PMP was able to effectively overcome their chemo-resistance with minimal side effects. Conclusion: Our findings demonstrated the Py-TPE/siRNA@PMP as a promising agent for the highly efficient treatment of PTX-resistant cells and overcoming the shortage of chemotherapy in ovarian cancer.

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“…Recently, aggregation-induced emission (AIE) photosensitizers show their superiority and strong potential. They are nearly nonemissive in molecular-dissolved state, but display strong emission when aggregated due to the restriction of intramolecular motions. − AIE photosensitizers are able to show both high fluorescence and efficient photosensitization in the aggregate state. − Moreover, the dynamic fluorescence transformation of aggregation-induced emission luminogens (AIEgens) under different circumstances is intriguing and significant, because it could be used to reflect the specific stimuli in tumor environment and monitor the structure changes of nanocarrier. − Though delightful developments, the antitumor efficiency of AIEgen-based PDT is not as good as expected and still far away from clinical applications due to the unsatisfying therapeutic efficiency.…”

mentioning

confidence: 99%

Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy

Dai

et al. 2021

ACS Nano

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Nowadays, aggregation-induced emission luminogens (AIEgens) with reactive oxygen species (ROS) generating ability have been used as photosensitizers for imaging guided photodynamic therapy (PDT). To achieve enhanced antitumor outcomes, combining AIEgens-based PDT with chemotherapy is an efficient strategy. However, the therapeutic efficiency is hampered by the limited cellular uptake efficiency and the appropriate light irradiation occasion. In this paper, a self-guiding polymeric micelle (TB@PMPT) composed of two AIE photosensitizers and a reduction-sensitive paclitaxel prodrug (PTX-SS-N3) was established for enhanced chemo-photodynamic therapy by a dual-stage light irradiation strategy. When the micelles were accumulated in tumor tissues, the first light irradiation (L1, 6 min) was utilized to facilitate cellular uptake by “photochemical internalization” (PCI). Then, the intracellular glutathione (GSH) would induce the PTX release, micelles disassembly and the aggregation state change of AIEgens. The fluorescence signal change of two AIEgens-based ratiometric fluorescent probe could not only precisely guide the second light irradiation (L2, 18 min) for sufficient ROS production, but also monitor the nonfluorescent drug PTX release in turn. Both in vivo and in vitro studies demonstrated that the dual-stage light irradiation strategy employed for TB@PMPT micelles exhibited a superior therapeutic effect over only 24 min continuous light irradiation.

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Rational Fabrication and Biomedical Application of Biomolecule‐Conjugated AIEgens through Click Reaction

Cited by 13 publications

References 93 publications

Near‐Infrared Fluorescent Nanoprobe for Detecting Hydrogen Peroxide in Inflammation and Ischemic Kidney Injury

Near‐Infrared Fluorescent Nanoprobe for Detecting Hydrogen Peroxide in Inflammation and Ischemic Kidney Injury

Biocompatible AIEgen/p-glycoprotein siRNA@reduction-sensitive paclitaxel polymeric prodrug nanoparticles for overcoming chemotherapy resistance in ovarian cancer

Self-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapy

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