“…G-quadruplexes (G4) are widely present throughout the human genome especially in the promoters 36,37 , telomeres 38,39,40 , UTRs 41,42 , intronic regions of genes involved in development, survival and proliferation 43,44 . These four-stranded nucleic acid structures are also increasingly being recognized as regulatory elements for replication, transcription, and other important regulatory roles 45,46,47,48 .…”