Rational design of silicon structures for optically controlled multiscale biointerfaces

Jiang, Yuanwen; Li, Xiaojian; Liu, Bing; Yi, Jaeseok; Fang, Yin; Shi, Fengyuan; Gao, Xiang; Sudzilovsky, Edward; Parameswaran, Ramya; Koehler, Kelliann; Nair, V. P.; Yue, Jiping; Guo, Kuang Hua; Tsai, Hsiu Ming; Freyermuth, George; Wong, Raymond; Kao, Chien-Min; Chen, Chin Tu; Nicholls, A.; Wu, Xiaoyang; Shepherd, Gordon M.; Tian, Bozhi

doi:10.1038/s41551-018-0230-1

Cited by 199 publications

(349 citation statements)

References 58 publications

(75 reference statements)

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“…Light is converted to heat energy due to decay of plasmon oscillations, and the resultant temperature variation induces a membrane potential change through a transient membrane capacitance shift [14]. Recently, some evidence showing that metal decoration can support increase on capacitive and Faradaic currents were also reported [8]. In this study, we demonstrate that the coupling of plasmons to photocapacitors can improve the charge injection of the neuromodulating displacement currents in the entire visible range.…”

Section: Introductionmentioning

confidence: 61%

“…Capacitive charge-injection, which is a safe method for stimulation of neurons [8], is based on the electromagnetic attraction and repulsion of the ions in the biological medium due to charge movement in the stimulating electrode. For that the fabrication of plasmonic biointerface architecture (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Since the capacitive current in the plasmonic biointerface is effectively based on the hole accumulation at the electrode-electrolyte interface, the holes remained after hot electron injection inside the gold nanoislands and the ones that moved to the PTB7-Th due to low potential barrier lead to the capacitive enhancement. Therefore, even though electron relaxation through electron–electron and electron–phonon collisions that are converted into heat energy was generally used as the main mechanism for cell stimulation [4–8], differently in this study both hot electron injection and near-field enhancement are used to improve the displacement currents.…”

Section: Discussionmentioning

confidence: 99%

“…Extracellular stimulation is the basis for the communication with the biological systems to recover lost functionalities [1], understand cellular processes [2] and switch neural networks [3]. For that light offers a non-invasive neuromodulation trigger with high spatial and temporal precision [4–8]. Optogenetics introduces light-sensitive opsins into the membrane via a viral transfection, but genetic modification currently raises concerns on their clinical use [9, 10].…”

Section: Introductionmentioning

confidence: 99%

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Plasmon-Coupled Photocapacitor Neuromodulators

Melikov

Srivastava

Karatum

et al. 2020

Preprint

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Efficient transduction of optical energy to bioelectrical stimuli is an important goal for effective communication with biological systems. For that plasmonics has significant potential via boosting the light-matter interactions. However, plasmonics has been primarily used for heat-induced cell stimulation due to membrane capacitance change (i.e., optocapacitance). Instead, here we demonstrate that plasmonic coupling to photocapacitor biointerfaces improves safe and efficacious neuromodulating displacement charges for an average of 185% in the entire visible spectrum while maintaining the Faradaic currents below 1%. Hot-electron injection dominantly leads the enhancement of displacement current at blue spectral window, and nanoantenna effect is mainly responsible for the improvement at redspectral region. The plasmonic photocapacitor facilitates wireless modulation of single cells at 3-orders of magnitude below the maximum retinal intensity levels corresponding to one of the most sensitive optoelectronic neural interfaces. This study introduces a new way of using plasmonics for safe and effective photostimulation of neurons and paves the way toward ultrasensitive plasmon-assisted neurostimulation devices.

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Section: Introductionmentioning

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Plasmon-Coupled Photocapacitor Neuromodulators

Melikov

Srivastava

Karatum

et al. 2020

Preprint

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“…Linking light‐controlled modulation of neurotransmitter release from brain slices to adjust brain activity in vivo, scientists tried to design a light‐sensing system to mimic this process. An artificial optic‐neural synaptic (ONS) element composed of a synapse device and an optical sensor device has the dual functions of synapses and optical sensors.…”

Section: Artificial Sensory Systemsmentioning

confidence: 99%

Recent Progress in Three‐Terminal Artificial Synapses: From Device to System

Han

Wei

et al. 2019

Small

244

233

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Synapses are essential to the transmission of nervous signals. Synaptic plasticity allows changes in synaptic strength that make a brain capable of learning from experience. During development of neuromorphic electronics, great efforts have been made to design and fabricate electronic devices that emulate synapses. Three‐terminal artificial synapses have the merits of concurrently transmitting signals and learning. Inorganic and organic electronic synapses have mimicked plasticity and learning. Optoelectronic synapses and photonic synapses have the prospective benefits of low electrical energy loss, high bandwidth, and mechanical robustness. These artificial synapses provide new opportunities for the development of neuromorphic systems that can use parallel processing to manipulate datasets in real time. Synaptic devices have also been used to build artificial sensory systems. Here, recent progress in the development and application of three‐terminal artificial synapses and artificial sensory systems is reviewed.

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Ultra‐Compliant and Tough Thermochromic Polymer for Self‐Regulated Smart Windows

Zhang

Jiang

Chen

et al. 2021

Adv Funct Materials

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Smart windows have shown powerful potential in modulating sunlight and energy management. However, there has not been a single system that can simultaneously possess all desired properties, that is, high compliance, wide tunability, and autonomous regulation. Here, a novel system based on polyhedral oligomeric silsesquioxane crosslinked poloxamer is demonstrated. The as‐synthesized material simultaneously possesses a number of the desired properties for smart windows. In addition, with the incorporation of gold nanorods, the as‐fabricated smart window can be operated in an autonomous fashion with its transmission being modulated automatically upon environmental temperature shifts. Finally, the high toughness and high stretchability (10 000% strain) of the material also pave a way for future applications in wearable displays or flexible window screens.

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Rational design of silicon structures for optically controlled multiscale biointerfaces

Cited by 199 publications

References 58 publications

Plasmon-Coupled Photocapacitor Neuromodulators

Plasmon-Coupled Photocapacitor Neuromodulators

Recent Progress in Three‐Terminal Artificial Synapses: From Device to System

Ultra‐Compliant and Tough Thermochromic Polymer for Self‐Regulated Smart Windows

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