Rational design of metallophosphors with tunable aggregation-induced phosphorescent emission and their promising applications in time-resolved luminescence assay and targeted luminescence imaging of cancer cells

Liu, Shujuan; Sun, Huibin; Ma, Yun; Ye, Shanghui; Liu, Xiangmei; Zhou, X. H.; Mou, Xin; Wang, Lianhui; Zhao, Qiang; Huang, Wei

doi:10.1039/c2jm34512a

Cited by 96 publications

(73 citation statements)

References 63 publications

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“…The platinum satellites for the imine resonances (JHPt ~ 62 Hz) are consistent with other (salicylaldiminato)platinum complexes [18][19][20][21][22][23][24][25][26]. The FT-IR spectra show the expected decrease in the frequency of the C=N bond due to complexation, which is observed as the νC=N stretch shifts from ca.1632 cm -1 for the free ligands to ca.…”

supporting

confidence: 61%

Synthesis, characterization, and anticancer properties of organometallic Schiff base platinum complexes

et al. 2015

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A small family of organometallic platinum complexes containing a chloride, ciscyclooctene, and a Schiff base ligand have been prepared and characterized fully. Three aliphatic amines and four aromatic amines were chosen as representative examples. All complexes were stable in air except for 7, derived from the pinacol-protected 4-aminophenylboronate ester 4-H2NC6H4Bpin (pin = 1,2-O2C2Me4), which decomposed via B-C bond cleavage.Both complex 4 (derived from aniline) and 7 were further characterized by single crystal X-ray diffraction studies and confirmed the square planar nature of the platinum center whereby the chloride ligand lies trans to the deprotonated hydroxyl group of the Schiff base ligand. The imine functionality is trans to the organic cyclooctene group. Complex 3, which contained the longest aliphatic chain studied (an octyl group), was the most promising for inducing apoptosis in the malignant MB231 breast cancer cell line. Conversely, complexes 4-6, which contained aromatic groups, were the most active against Renal Cell Carcinoma (RCC) cell lines. Graphical Abstract: Seven new organometallic (salicylaldiminato)platinum(II) complexes have been prepared, and characterized fully, whereupon six of these new compounds were examined for their in vitro cytotoxic properties against breast cancer cell line MB231 and Renal Cell Carcinoma (RCC) cell lines.

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confidence: 61%

Synthesis, characterization, and anticancer properties of organometallic Schiff base platinum complexes

et al. 2015

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“…However, AIPE-active iTMCs can avoid interference from oxygen due to the complexes being encapsulated within the nanoparticles formed in suspension, which can protect them from oxygen. 13 In summary, a new dinuclear ionic iridium complex 1•2PF 6 shows a rapid, highly selective phosphorescent turn-on response to perchlorate in aqueous media by aggregation induced emission. The structural versatility of iTMCs will enable the scope of this new "anion-exchange induced AIPE" process to be explored in the selective phosphorescence-based detection of anions, for which it may be a general strategy.…”

Section: This Journal Is © the Royal Society Of Chemistry 2014mentioning

confidence: 95%

“…6b,12 For anion detection in vivo, the output signal of AIE-active fluorophores always suffers from the interference of short-lifetime background fluorescence and scattered light. 13 We considered that aggregation-induced phosphorescent emission (AIPE) using iTMCs may be an alternative, unexplored strategy for the turn-on detection of anions due to the long lifetime of phosphorescent emission. Moreover, compared with netural complexes, iTMCs could show highly selective recognition of anions through the interactions between the cation and anion moieties.…”

Section: Ionic Transition Metal Complexes (Itmcs) Notably Those Of Imentioning

confidence: 99%

Anion-specific aggregation induced phosphorescence emission (AIPE) in an ionic iridium complex in aqueous media

Guan

et al. 2015

Chem. Commun.

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(2015) 'Anion-speci c aggregation induced phosphorescence emission (AIPE) in an ionic iridium complex in aqueous media.', Chemical communications., 51 (95). pp. 16924-16927. Further information on publisher's website:Publisher's copyright statement:Additional information: Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details.

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“…To enhance the EL efficiencies using these types of iridium complexes as single emitter, a key issue would be the structural modification of ligands to facilitate the excimer formation without loss of emission efficiency from excimers. In this regard, materials with aggregation-induced emission properties 14,15 would contribute to the development of the efficient WOLEDs using single emitter. …”

Section: Discussionmentioning

confidence: 99%

Phosphorescent Iridium Complexes for OLEDs Based on 1-Phenylpyrazole Ligands with Fluorine and Methyl Moieties

Yoon¹,

Song²,

Na³

et al. 2013

Bulletin of the Korean Chemical Society

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A series of phosphorescent iridium(III) complexes 1-4 based on phenylpyrazole were synthesized and their photophysical properties were investigated. To evaluate their electroluminescent properties, OLED devices with the structure of ITO/NPB/mCP: 8% Iridium complexes (1-4)/TPBi/Liq/Al were fabricated. Among those, the device with 3 showed the most efficient white emission with maximum luminance of 100.6 cd/m 2 at 15 V, maximum luminous efficiency of 1.52 cd/A, power efficiency of 0.71 lm/W, external quantum efficiency of 0.59%, and CIE coordinates of (0.35, 0.40) at 15.0 V, respectively.

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Rational design of metallophosphors with tunable aggregation-induced phosphorescent emission and their promising applications in time-resolved luminescence assay and targeted luminescence imaging of cancer cells

Cited by 96 publications

References 63 publications

Synthesis, characterization, and anticancer properties of organometallic Schiff base platinum complexes

Synthesis, characterization, and anticancer properties of organometallic Schiff base platinum complexes

Anion-specific aggregation induced phosphorescence emission (AIPE) in an ionic iridium complex in aqueous media

Phosphorescent Iridium Complexes for OLEDs Based on 1-Phenylpyrazole Ligands with Fluorine and Methyl Moieties

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