Rational design of COF–MOF composites for ratiometric fluorescence detection of phosphate

Abstract

Integrating covalent organic framework (COF)-metal organic framework (MOF) hybrid materials is an effective way to develop a ratiometric fluorescent method. Herein, we firstly reported a strategy for growth of lanthanide...

Enhancing Kinase Activity Detection with a Programmable Lanthanide Metal–Organic Framework via ATP-to-ADP Conversion

“…Metal–organic frameworks (MOFs) are a class of porous crystalline materials characterized by their periodic and infinite spatial networks and formed through the coordination of metal ions and organic ligands. , Their inherent programmability makes them invaluable in creating versatile sensing platforms and provides opportunities for the precise regulation of guest molecule adsorption and sensing capabilities. − Among MOFs, lanthanide-based variants (Ln-MOFs) stand out for their exceptional optical properties, including prolonged fluorescence lifetimes, significant Stokes shifts, resistance to photobleaching, and remarkable monochromaticity, making them particularly promising in sensing applications, especially in detecting small molecules like phosphates. − The robust affinity of Ln-MOFs for phosphate groups has propelled their widespread use in adsorption, degradation, and sensor development. − For example, the Luo research group has demonstrated the effective retrieval of phosphates using La-MOFs, highlighting electrostatic interactions as the primary adsorption mechanism . The Ke group has engineered a Tb/Eu-MOF based sensor capable of detecting low levels of PO 4 3– and ATP .…”