Rational design of bioceramic scaffolds with tuning pore geometry by stereolithography: Microstructure evaluation and mechanical evolution

Lu, Fengling; Wu, Ronghuan; Shen, Miaoda; Xie, Lijun; Liu, Mengtao; Li, Yifan; Xu, Sanzhong; Wan, Li; Yang, Xianyan; Gao, Changyou; Gou, Zhongru

doi:10.1016/j.jeurceramsoc.2020.10.002

Cited by 49 publications

(38 citation statements)

References 46 publications

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“…Briefly speaking, the mass ( m 1 ) of sintered scaffolds was weighed, respectively, and then the diameter ( D ) and height ( H ) were also measured by using Vernier caliper. The real porosity of the scaffolds ( n = 6) could be calculated using the equation [ 35 ]: Porosity = (1- m s /(π ρ 0 ( D/2 ) 2 H )) × 100%, where m s , and ρ 0 were the mass of the sample and density of wollastonite (2.96 g/mm 3 ).…”

Section: Methodsmentioning

confidence: 99%

Bone tissue regeneration: The role of finely tuned pore architecture of bioactive scaffolds before clinical translation

Shen

et al. 2021

Bioactive Materials

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Spatial dimension of pores and interconnection in macroporous scaffolds is of particular importance in facilitating endogenous cell migration and bone tissue ingrowth. However, it is still a challenge to widely tune structure parameters of scaffolds by conventional methods because of inevitable pore geometrical deformation and poor pore interconnectivity. Here, the long-term in vivo biological performances of nonstoichiometric bioceramic scaffolds with different pore dimensions were assessed in critical-size femoral bone defect model. The 6% Mg-substituted wollastonite (CSi-Mg6) powders were prepared via wet-chemical precipitation and the scaffolds elaborately printed by ceramic stereolithography, displaying designed constant pore strut and tailorable pore height (200, 320, 450, 600 μm), were investigated thoroughly in the bone regeneration process. Together with detailed structural stability and mechanical properties were collaboratively outlined. Both μCT and histological analyses indicated that bone tissue ingrowth was retarded in 200 μm scaffolds in the whole stage (2–16 weeks) but the 320 μm scaffolds showed appreciable bone tissue in the center of porous constructs at 6–10 weeks and matured bone tissue were uniformly invaded in the whole pore networks at 16 weeks. Interestingly, the neo-tissue ingrowth was facilitated in the 450 μm and 600 μm scaffolds after 2 weeks and higher extent of bone regeneration and remodeling at the later stage. These new findings provide critical information on how engineered porous architecture impact bone regeneration in vivo . Simultaneously, this study shows important implications for optimizing the porous scaffolds design by advanced additive manufacture technique to match the clinical translation with high performance.

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Section: Methodsmentioning

confidence: 99%

Bone tissue regeneration: The role of finely tuned pore architecture of bioactive scaffolds before clinical translation

Shen

et al. 2021

Bioactive Materials

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“…The values of elastic modulus and strength of cancellous bone are 10 to 1570 MPa and 1.5 to 38 MPa, respectively [33]. The researchers have been designed and successfully printed various ceramic bone scaffold [15,21,23]. The DLPprinted ZrO2 with different lattice structures would show great potential in the implant field.…”

Section: Mechanical Propertymentioning

confidence: 99%

“…Among the various AM techniques that be used for ceramic parts fabrication (three-dimensional printing (3DP) [9], stereolithography (SLA) [10], 3D gelprinting [11], a robocasting technique [12], direct inkjet printing (DIP) [13] and fused deposition modeling (FDM) [14], etc. ), digital light processing (DLP) [4,[15][16][17][18][19][20][21][22][23] is one of the most promising technique. These parts fabricated by this technique exhibit fine surface finishing and very high spatial resolution.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Static Bending Properties of 3D Printed Zirconia Part via Digital Light Processing Method

Wang

Arab

Xie

et al. 2021

Preprint

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Zirconia is widely applied as an implant due to its’ excellent biocompatibility and mechanical properties such as high hardness and extraordinary resistance to wear and corrosion. However, these outstanding mechanical properties make it challenging to fabricate Zirconia into complex shapes using conventional manufacturing techniques. In the current study, the digital light processing method was used to manufacture the Zirconia part. Its mechanical property was evaluated via a three-point bending test with digital image correlation and fractography analysis. The 3D-printed Zirconia sample had a relative density of approximately 98.8% and a Vickers hardness value of 1128 HV. The flexural strength under parallel and vertical bending loads (with respect to the printing direction) were 56.63±3.97MPa and 70.98±6.62MPa, respectively. Surrounding by a few dense layers, the interior of the sintered sample was interlaced with needle-like and winding cracks. Under the three-point bending, the cracks initiated at the bottom surface due to the tension effect and propagated faster along the width direction than the thickness direction. There was a large area of cleavage morphology in the dense boundary layers, whereas the plastic fracture mode also appeared in the interior of the sintered samples. The digital light processing method is expected to be comparable to other advanced ceramic processing techniques for fabricating spatial lattice structural products.

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“…Additive manufacturing (AM) technologies, in general, have a great potential for the obtainment of advanced bioceramic scaffolds featuring complex shapes. Ideally, the structure of macroporous scaffolds can be easily tailored using computer-aided design (CAD), subsequently transferred to several AM machines [ 4 , 5 ]. Recent efforts have been devoted to the development of micro/nanoporous structures in the same scaffolds through processing routes [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Hierarchically Porous Lattice Structures Based on Åkermanite Glass Microspheres and Reactive Silicone Binder

Dasan

Kraxner

Grigolato

et al. 2022

JFB

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The present study illustrates the manufacturing method of hierarchically porous 3D scaffolds based on åkermanite as a promising bioceramic for stereolithography. The macroporosity was designed by implementing 3D models corresponding to different lattice structures (cubic, diamond, Kelvin, and Kagome). To obtain micro-scale porosity, flame synthesized glass microbeads with 10 wt% of silicone resins were utilized to fabricate green scaffolds, later converted into targeted bioceramic phase by firing at 1100 °C in air. No chemical reaction between the glass microspheres, crystallizing into åkermanite, and silica deriving from silicone oxidation was observed upon heat treatment. Silica acted as a binder between the adjacent microspheres, enhancing the creation of microporosity, as documented by XRD, and SEM coupled with EDX analysis. The formation of ‘spongy’ struts was confirmed by infiltration with Rhodamine B solution. The compressive strength of the sintered porous scaffolds was up to 0.7 MPa with the porosity of 68–84%.

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Rational design of bioceramic scaffolds with tuning pore geometry by stereolithography: Microstructure evaluation and mechanical evolution

Cited by 49 publications

References 46 publications

Bone tissue regeneration: The role of finely tuned pore architecture of bioactive scaffolds before clinical translation

Bone tissue regeneration: The role of finely tuned pore architecture of bioactive scaffolds before clinical translation

Fabrication and Static Bending Properties of 3D Printed Zirconia Part via Digital Light Processing Method

3D Printing of Hierarchically Porous Lattice Structures Based on Åkermanite Glass Microspheres and Reactive Silicone Binder

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