Rational design of a stable, effective, and sustained dexamethasone delivery platform on a titanium implant: An innovative application of metal organic frameworks in bone implants

Ran, Jiabing; Zeng, Hao; Cai, Jing; Jiang, Pei; Peng, Yan; Zheng, Lingyue; Bai, Yiming; Shen, Xinyu; Shu, Bin; Tong, Hua

doi:10.1016/j.cej.2017.09.145

Cited by 47 publications

(19 citation statements)

References 63 publications

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“…An appropriate Zn 2+ concentration could enhance the adsorption of osteoblasts and activity of phosphatase, stimulate the proliferation and differentiation of osteoblasts, and inhibit the activity of osteoclasts; and (iv) DEX, an anti-inflammatory glucocorticoid, was widely used to induce osteogenic differentiation of bone marrow-derived mesenchymal stem cells in vitro . It could also significantly improve ALP activity and stimulate extracellular collagen matrix synthesis, calcium deposition, and mineralized nodule formation. , Moreover, DEX could also increase the transcription of osteocalcin, type I collagen, and bone bridge protein, promote osteogenic differentiation, and activate the function of osteoblasts …”

Section: Resultsmentioning

confidence: 99%

Fabrication of Dexamethasone-Loaded Dual-Metal–Organic Frameworks on Polyetheretherketone Implants with Bacteriostasis and Angiogenesis Properties for Promoting Bone Regeneration

Xiao

Fan

Liu

et al. 2021

ACS Appl. Mater. Interfaces

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Polyetheretherketone (PEEK) is a biocompatible polymer, but its clinical application is largely limited due to its inert surface. To solve this problem, a multifunctional PEEK implant is urgently fabricated. In this work, a dual-metal−organic framework (Zn−Mg-MOF74) coating is bonded to PEEK using a mussel-inspired polydopamine interlayer to prepare the coating, and then, dexamethasone (DEX) is loaded on the coating surface. The PEEK surface with the multifunctional coating provides superior hydrophilicity and favorable stability and forms an alkaline microenvironment when Mg 2+ , Zn 2+ , 2,5-dihydroxyterephthalic acid, and DEX are released due to the coating degradation. In vitro results showed that the multifunctional coating has strong antibacterial ability against both Escherichia coli and Staphylococcus aureus; it also improves human umbilical vein endothelial cell angiogenic ability and enhances rat bone marrow mesenchymal stem cell osteogenic differentiation activity. Furthermore, the in vivo rat subcutaneous infection model, chicken chorioallantoic membrane model, and rat femoral drilling model verify that the PEEK implant coated with the multifunctional coating has strong antibacterial and angiogenic ability and promotes the formation of new bone around the implant with a stronger bone−implant interface. Our findings indicate that DEX loaded on the Zn−Mg-MOF74 coating-modified PEEK implant with bacteriostasis, angiogenesis, and osteogenesis properties has great clinical application potential as bone graft materials.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Dexamethasone-Loaded Dual-Metal–Organic Frameworks on Polyetheretherketone Implants with Bacteriostasis and Angiogenesis Properties for Promoting Bone Regeneration

Xiao

Fan

Liu

et al. 2021

ACS Appl. Mater. Interfaces

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“…Furthermore, a key component of our culture media was dexamethasone, which possesses significant anti-inflammatory potential and supports pro-osteogenic differentiation. Recently, MOFs containing dexamethasone have been used to coat a titanium substrate showing good cytocompatibility and supporting osteogenic differentiation in a mouse cell line 27 . Reasonably, similar outcomes could be expected with human cells, and it would then be very promising to combine dexamethasone MOFs with CaSr-MOFs as coatings for titanium implants to promote osseointegration and ostoegenesis.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications

Joseph

Lawson

Overholt

et al. 2019

Sci Rep

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Metal-organic frameworks (MOFs) formed from metals and organic ligands, are crystalline materials that are degradable in aqueous medium, and capable of releasing Ca and Sr ions. In this manuscript, the ability of MOFs to degrade and release osteogenic Ca and Sr ions was investigated. MOFs were generated by choosing osteoinductive Ca and Sr metals, and an organic ligand 1,3,5 tricarboxylicbenzene (H3BTC) as a linker. These MOFs were able to induce in vitro biomineralization from pre-osteoblastic MC3T3 cells and human mesenchymal stem cells (hMSCs). Moreover, these MOFs (when loaded with dimethyloxalylglycine (DMOG)) induced vascular endothelial production from hMSCs. qRT-PCR analysis performed on hMSCs (isolated from femoral heads of patients undergoing joint arthroplasty) treated with MOFs crystals suggested that the CaSr-MOFs by themselves can upregulate osteogenic genes in hMSCs, which is the first time to our knowledge that this has been observed from MOFs.

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“…In particular, Ran et al constructed the silk fibroin–dexamethasone@zeolitic imidazolate framework-8 nanoparticle-loaded Ti. This Ti could control the release of DEX for a long time, enhance the expression of osteogenic related genes, and facilitate osteogenic mineralization [ 151 ]. The study suggested that the unique drug delivery system designed by the authors could also be used to deliver other osteogenic-related drugs or factors.…”

Section: Local Drug Delivery Systems With Ti-based Implantsmentioning

confidence: 99%

Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration

et al. 2022

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Titanium and its alloys are the most widely applied orthopedic and dental implant materials due to their high biocompatibility, superior corrosion resistance, and outstanding mechanical properties. However, the lack of superior osseointegration remains the main obstacle to successful implantation. Previous traditional surface modification methods of titanium-based implants cannot fully meet the clinical needs of osseointegration. The construction of local drug delivery systems (e.g., antimicrobial drug delivery systems, anti-bone resorption drug delivery systems, etc.) on titanium-based implants has been proved to be an effective strategy to improve osseointegration. Meanwhile, these drug delivery systems can also be combined with traditional surface modification methods, such as anodic oxidation, acid etching, surface coating technology, etc., to achieve desirable and enhanced osseointegration. In this paper, we review the research progress of different local drug delivery systems using titanium-based implants and provide a theoretical basis for further research on drug delivery systems to promote bone–implant integration in the future.

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Rational design of a stable, effective, and sustained dexamethasone delivery platform on a titanium implant: An innovative application of metal organic frameworks in bone implants

Cited by 47 publications

References 63 publications

Fabrication of Dexamethasone-Loaded Dual-Metal–Organic Frameworks on Polyetheretherketone Implants with Bacteriostasis and Angiogenesis Properties for Promoting Bone Regeneration

Fabrication of Dexamethasone-Loaded Dual-Metal–Organic Frameworks on Polyetheretherketone Implants with Bacteriostasis and Angiogenesis Properties for Promoting Bone Regeneration

Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications

Construction of Local Drug Delivery System on Titanium-Based Implants to Improve Osseointegration

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