Rational Design of a New Self‐Codelivery System from Redox‐Sensitive Camptothecin–Cytarabine Conjugate Assembly for Effectively Synergistic Anticancer Therapy

He, Wenxiu; Hu, Xu; Jiang, Wei; Liu, Ruiling; Zhang, Di; Zhang, Jing; Li, Zhonghao; Luan, Yuxia

doi:10.1002/adhm.201700829

Cited by 70 publications

(42 citation statements)

References 49 publications

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“…This synergistic effect coincide with the previously reported results of the conjugation of camptothecin and cytarabine through disulde linkage that showed a rapid cellular uptake with a synergistic anticancer activity in vitro and in vivo studies. 47 Importantly, there was no signicant cytotoxic activity with 3T3 broblasts, which might reect a preferential activity against cancerous cells.…”

Section: Mts Studymentioning

confidence: 97%

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

et al. 2019

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Section: Mts Studymentioning

confidence: 97%

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

et al. 2019

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“…To further confirm the photo‐cytotoxicity of T820/Ce6 micelles and clarify the mechanism of cell death induced by the micelles, cell apoptosis and necrosis were evaluated by apoptosis assay using Annexin‐V‐FITC (fluorescein isothiocyanate)/PI (propidium iodide) double staining . As illustrated in Figure , cell growth was not affected by laser irradiation, and treatment of free Ce6, T820 micelles, or T820/Ce6 micelles in darkness brought death to a small portion of the cells.…”

Section: Resultsmentioning

confidence: 99%

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Tian

Jiang

et al. 2018

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triggered by near-infrared (NIR) lightexcited photothermal agents [10] while PDT causes the cell death by photosensitizers generating highly cytotoxic reactive oxygen species (ROS) upon light excitation. [11][12][13] With distinct mechanisms of action, the integration of PTT and PDT into one nanoplatform holds great potential to achieve highly efficient cancer therapy. [14][15][16] However, in such combined therapy, two different excitation wavelengths are usually required for the activation of PTT and PDT, [17][18][19] leading to complicated treatment process and prolonged therapeutic time. Thus, it is highly desirable to design a nanoplatform with single NIR light-induced phototherapy.Although strategies of single-wavelength NIR light-mediated PTT/PDT combination therapy have been reported, photothermal agents commonly used in combined systems are inorganic nanomaterials, like gold nanostructures, [20][21][22] MoS 2 nanosheets, [23] black phosphorus nanosheets, [24] and black titania, [25] which show tedious preparation process, poor degradation, difficult excretion, and potential long-term toxicity. NIR organic dyes, which possess unique advantages of outstanding biodegradability and biocompatibility in contrast with inorganic photothermal agents, will be ideal alternatives. Especially, for new indocyanine green (IR820), a structural analog of indocyanine green (ICG), which has been approved by the Food and Drug Administration (FDA) in clinical use, [26][27][28] holds the suitable fluorescence, strong absorption in NIR region, and efficient light-thermal conversion. [29,30] Additionally, it is more stable and easily modified due to the meso-halogen in its chemical structure. Unfortunately, it differs from organic photodynamic agents in intrinsic excitation wavelength, bringing a great challenge to achieve single NIR laser-induced combinational phototherapy. Moreover, it suffers from short half-life in blood, rapid clearance from the body, and lack of specificity to target tumor area. [31,32] Chlorin e6 (Ce6), an FDA-approved second-generation photosensitizer, [33] is extensively used in PDT on account of its high singlet oxygen generation efficiency, [34] near-infrared light excitation allowing deep tissue penetration, and fluorescence imaging capability. [35,36] Despite these upsides, Ce6 has shortcomings including poor water solubility and nonspecific accumulation in tumor sites, [37] which largely compromise Phototherapy as a promising cancer diagnostic and therapeutic strategy has aroused extensive attention. However, single-wavelength near-infrared (NIR) light-triggered combinational treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) is still a great challenge. Herein, a multifunctional micelle activated by a single-wavelength laser for simultaneous PTT and PDT as well as fluorescence imaging is developed. Briefly, new indocyanine green (IR820) is conjugated to d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) via the linker 6-aminocaproic acid, and then, chlorin e6 (Ce6) is enc...

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“…Ara-C has a short plasma half-life, low lipophilicity and stability, and limited bioavailability. Some efforts have been devoted to enhancing the low bioavailability and stability of Ara-C [44]. These efforts can be divided into two major categories depending upon formulation and modification: prodrugs and drug delivery systems.…”

Section: Bioavailability and Sourcesmentioning

confidence: 99%

“…For example, cytarabine was conjugated in a self-assembling nanoparticle which included glutathione cleavable disulfide bond [44]. This combination resulted in a redox-sensitive drug-drug conjugate, more cell membrane permeable and more resistant to biological inactivation before arrival into tumor tissue.…”

Section: Cytarabine Nanoparticles In Preclinical Settingsmentioning

confidence: 99%

Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine

et al. 2019

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Cancer is the second leading cause of death worldwide. The main modality to fight against cancer is surgery, radiotherapy, and chemotherapy, and more recently targeted therapy, gene therapy and immunotherapy, which play important roles in treating cancer patients. In the last decades, chemotherapy has been well developed. Nonetheless, administration of the drug is not always successful, as limited drug dosage can reach the tumor cells.. In this context, the possibility to use an encapsulated anti-cancer drug may potentially solve the problem. Liposomal cytarabine is a formulation with pronounced effectiveness in lymphomatous meningitis and reduced cardiotoxicity if compared to liposomal anthracyclines. Thus, the future liposomal cytarabine use could be extended to other diseases given its reduction in cytotoxic side effects compared to the free formulation. This review summarizes the chemistry and biology of liposomal cytarabine, with exploration of its clinical implications.

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Rational Design of a New Self‐Codelivery System from Redox‐Sensitive Camptothecin–Cytarabine Conjugate Assembly for Effectively Synergistic Anticancer Therapy

Cited by 70 publications

References 49 publications

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

Combretastatin A4-camptothecin micelles as combination therapy for effective anticancer activity

Rational Design of IR820‐ and Ce6‐Based Versatile Micelle for Single NIR Laser–Induced Imaging and Dual‐Modal Phototherapy

Liposomal Cytarabine as Cancer Therapy: From Chemistry to Medicine

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