“…Several flavonoids with antitumor activity are known in the literature [ 10 , 11 ]. Flavones containing a 2-phenylchromen-4-one ( 1 ) backbone, and 1,2,3-triazole derivatives keep attracting much research interest, and many 1,2,3-triazole-containing hybrids are known as effective anticancer agents [ 12 , 13 , 14 , 15 ]. During the last decade, numerous biologically active flavone—1,2,3-triazole hybrids have been synthesized [ 16 , 17 , 18 ], for example, 5 apigenin-7-methyl ether derivative, which showed promising activity against ovarian cancer ( IC 50 = 10, 15 and 20 µM for SKOV3, OVCAR-3 and Caov-3 cancer cell lines) ( Figure 1 ) [ 19 ].…”