Rational design, chemical synthesis and cellular evaluation of novel 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents

Patel, Amiya Kumar; Meher, Rajesh Kumar; Reddy, Priyanka; Pedapati, Ravi Kumar; Pragyandipta, Pratyush; Kantevari, Srinivas; Naik, Manas Ranjan; Naik, Pradeep Kumar

doi:10.1016/j.jmgm.2021.107933

Cited by 14 publications

(2 citation statements)

References 39 publications

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“…Several groups of the most potent derivatives have been designed, synthesized, and experimentally evaluated for their therapeutic efficacy against multiple cancer cell lines to resolve the issue. [97][98][99][100][101][102]…”

Section: Curcuminmentioning

confidence: 99%

Natural therapeutics for cancer treatment: success, challenges, and prospect

Dubey,

Rath,

Meher

et al. 2023

J Bio-X Res

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Cancer is a terrifying disease that has become one of the world’s most challenging health concerns, necessitating a proactive approach to its treatment. Nature is a rich source of new chemical entities and a promising avenue for cancer research. Because of their different modes of action on target events in many ways, nature-derived chemicals are considered good possibilities for anticancer drug development. The current review article highlights recent breakthroughs in cancer therapeutics, including natural therapeutic molecules and their mechanisms of action against cancer treatment, as well as their limits, challenges, and prospect. For the review, article data have been collected from previously studied and published research reports, clinical evaluations, case studies, and clinical statistical data generated by scientific research organizations of repute. The chemical structures have been drawn using computational software (chemsketch). The development of promising candidates that can prevent or reduce the proliferation of cancer cells without causing adverse effects from these therapeutics is now underway. Further, nature-derived products are a game-changer because they are simple, safer, environmentally friendly, low-cost, quick, and less toxic than traditional treatment techniques. However, many bioactive chemicals and their analogs have been discovered as possible anticancer treatment options. In the review, the potent therapeutics phytochemicals derived from nature with their tremendous anticancer effects with limitations and prospects have been studied and analyzed based on previously published articles and reports.

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Section: Curcuminmentioning

confidence: 99%

Natural therapeutics for cancer treatment: success, challenges, and prospect

Dubey,

Rath,

Meher

et al. 2023

J Bio-X Res

Self Cite

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“…The methanolic extract of Dioscorea bulbifera was added to cell medium with increasing concentrations from (6.25 to 100 µg/ml) and incubated for 72 h. The sulphorhodamine B (SRB) assay was performed to study viability of cells and absorbance was read at a wavelength of 495nm using a Bio Red 96 well plate reader (BioRed-India). The IC50 value for the extract was calculated from the plate reader data by using an online IC50 value Calculator (AAT Bioquest, Inc., Sunnyvale, CA, USA) (Saluja et al, 2020;Meher et al, 2021c;Patel et al, 2021). DAPI staining for apoptosis detection 4',6-diamidino-2-phenylindole (DAPI) fluorescence stain was used to study apoptotic activities with fluorescence microscopy.…”

Section: Anticancer Evaluation By Using Mcf-7 and Mdamb-231 Cell Linesmentioning

confidence: 99%

Induction of apoptosis on breast adenocarcinoma and suppression of pathogenic bacterial growth by antioxidant rich tuber extract of Dioscorea Bulbifera

Induar

Meher

Dubey

et al. 2022

AUDJG - Food Technology

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Nature derived product drew a lot of interest because of their potential nutritional and therapeutics value. Most natural compounds are now processed and developed as possible antioxidative, antimitotic, antimicrobial, anti-inflammatory, antiangiogenic, and anti-carcinogenic pharmaceutical agents. Indeed, several natural products have been used as lead compounds in the development of most potent physiologically relevant chemicals for therapeutic application. In the current study antioxidant and anticancer potential of tuber extract of Dioscorea bulbifera have been determined as well as its antimicrobial potential against pathogenic bacteria. The IC50 value for the extract was found to be 55µg/ml for MCF-7 and 75µg/ml for MD-AMB-231 human breast cancer adenocarcinoma whereas minimum inhibitory concentration (MIC) value of the methanolic extract against S. aureus was 0.19 mg/ml and minimum bactericidal concentration (MBC) was 1.56 mg/ml. Further to identify compounds responsible for antioxidant, anticancer and antimicrobial activity GCMS analysis of the extract was conducted. Histopathological and haematological assay were carried out on animal model to identify any toxic effect of extract on vital organ system. This study may be used to provide the groundwork for the creation of novel nature-derived drugs whose biological activity can be determined by further purification, characterization, and validation of the active phytochemicals and their mechanism of action.

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