Rational design and virtual screening identify mimetics of the RXR agonist valerenic acid
Laura Isigkeit,
Annette Kärcher,
Gustave Adouvi
et al.
Abstract:The ligand‐sensing transcription factor retinoid X receptor (RXR) is the universal heterodimer partner of nuclear receptors and involved in multiple physiological processes. Its pharmacological modulation holds therapeutic potential in cancer and neurodegeneration but many available RXR ligands lack specificity. The sesquiterpenoid valerenic acid has been identified as RXR agonist with unprecedented subtype and homodimer preference. Here, we identified simplified mimetics of the complex natural product by rati… Show more
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