Ratiometric SERS imaging for indication of peroxynitrite fluctuations in diabetic wound healing process

Near-Infrared Fluorescence Probe for Indication of the Pathological Stages of Wound Healing Process and Its Clinical Application

“…Excessive infiltration of neutrophils appears to be one of the culprits of chronic wound healing . Abundant reactive oxygen species (ROS) in neutrophils is involved in all phases of wound healing, which can cause oxidative stress and adversely affect wound healing even prevent new tissue formation. − As a critical member of ROS, when hydrogen peroxide (H 2 O 2 ) is generated at low concentrations (<0.7 μM) in a regulated fashion, it functions as a ubiquitous intracellular second messenger, which plays key roles in various physiological processes including cell growth, inflammation treatment, proliferation and differentiation, and activation of immune cells. − The previous researches indicate that H 2 O 2 , nitric oxide (NO), hypochlorous acid (HClO) involve in wound healing and its concentration is fluctuated in different pathological stages during the wound healing process. − While these studies are excellent, they are mainly focused on studies with zebrafish or tissue sections, and few studies have been used to detect changes in the levels of these substances during wound healing over a long period. Therefore, we attempted to monitor for a prolonged period of time the changes in H 2 O 2 levels during wound healing in mice.…”

Multi-Shell Nanourchin-Integrated Dual Mode Lateral Flow Immunoassay for Sensitive and Rapid Detection of Clinical Cardiac Myosin-Binding Protein C

“…Gold nanoparticles (AuNPs) are regarded as a typical SERS substance in biological analysis with the excellent stability and biocompatibility but the relatively low detection sensitivity. − To solve this problem, various isotropic nanoparticles (Au@Ag NPs, − Fe 3 O 4 @Ag magnetic NPs, etc.) and anisotropic nanoparticles (Au nanostars, , Au nanoflower@Ag NPs, gap-enhanced Raman tags on AuNR cores, etc.)…”