Ratiometric sensing of β-galactosidase based on excited-state intramolecular proton transfer (ESIPT) and solid-state luminescence enhancement

Abstract

Glycosidases play important roles in modulating the structural and functional integrity of glycoproteins and glycolipids, and thus are promising biomarkers for disease diagnosis. While current approaches for glycosidase detection mainly...

Isoindoline-based fluorogenic probes bearing a self-immolative linker for the sensitive and selective detection of O-GlcNAcase activity

“…With this rationale, fluorogenic probes for many diverse glycosidases have been developed for the intracellular and in vivo imaging of their activities. 6,7 Glycosidase-activatable prodrugs have also been developed for therapy of cancer and senescence. 8,9…”