Ratiometric fluorescent sensors for nitrite detection in the environment based on carbon dot/Rhodamine B systems

Tao, Huihui; Zhang, Zhao; Cao, Qiao; Li, Lingfei; Xu, Shihao; Jiang, Changlong; Li, Yucheng; Liu, Yingying

doi:10.1039/d2ra00973k

Cited by 12 publications

(4 citation statements)

References 52 publications

(51 reference statements)

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“…Chemical surface modification introduces various functional groups onto CD surfaces to enhance solubility, reactivity, and specific ligand conjugation [ 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ] ( Figure 1 a). For instance, Xu et al [ 74 ] reported a ratiometric CD pH sensor enriched with amino groups, enabling them to specifically target lysosomes within living cells.…”

Section: Construction Strategies Of Cds In Detecting Environmental Co...mentioning

confidence: 99%

“…Anions: CD-based probes have been employed for detecting various anions, including phosphate (Pi) [ 87 , 103 , 151 ], nitrite (NO 2 − ) [ 68 , 152 ], hypochlorite (ClO − ) [ 153 , 154 ], bisulfite [ 155 ], and sulfide (S 2− ) [ 156 ] in water sources, facilitating the assessment of water quality.…”

Section: Application In Environmental Monitoringmentioning

confidence: 99%

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Advances in Carbon Dot-Based Ratiometric Fluorescent Probes for Environmental Contaminant Detection: A Review

Xing,

Wang,

Wang

2024

Micromachines

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Detecting environmental contaminants is crucial for protecting ecosystems and human health. While traditional carbon dot (CD) fluorescent probes are versatile, they may suffer from limitations like fluctuations in signal intensity, leading to detection inaccuracies. In contrast, ratiometric fluorescent probes, designed with internal self-calibration mechanisms, offer enhanced sensitivity and reliability. This review focuses on the design and applications of ratiometric fluorescent probes based on CDs for environmental monitoring. Our discussion covers construction strategies, ratiometric fluorescence principles, and applications in detecting various environmental contaminants, including organic pollutants, heavy metal ions, and other substances. We also explore associated advantages and challenges and provide insights into potential solutions and future research directions.

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Section: Construction Strategies Of Cds In Detecting Environmental Co...mentioning

confidence: 99%

Section: Application In Environmental Monitoringmentioning

confidence: 99%

Advances in Carbon Dot-Based Ratiometric Fluorescent Probes for Environmental Contaminant Detection: A Review

Xing,

Wang,

Wang

2024

Micromachines

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“…32,33 Rhodamine B (RhB) is a common xanthene fluorescent dye, which could be constant as a reference peak of the ratiometric fluorescent probe. 34,35 To the best of our knowledge, there is no relevant report that rhodamine B can directly react with ATP, so it has great potential to act as a reference fluorophore for ATP detection. Furthermore, Cu doping could reduce the FL intensity of CDs effectively and then realize the sensing process from "off" to "on" via the competitive combination of ATP and Cu, giving a possible protocol to design dual-emission CDs.…”

Section: Introductionmentioning

confidence: 99%

“…It could improve the emission characteristics of CDs, enhance the FL, and increase the FL yield . Moreover, compared to the single-emission FL, ratiometric FL could quantitatively detect the analyte through a change in the ratio of the two FL intensities, which eliminates the background signal and environmental interference to a certain extent. , Rhodamine B (RhB) is a common xanthene fluorescent dye, which could be constant as a reference peak of the ratiometric fluorescent probe. , To the best of our knowledge, there is no relevant report that rhodamine B can directly react with ATP, so it has great potential to act as a reference fluorophore for ATP detection. Furthermore, Cu doping could reduce the FL intensity of CDs effectively and then realize the sensing process from “off” to “on” via the competitive combination of ATP and Cu, giving a possible protocol to design dual-emission CDs …”

Section: Introductionmentioning

confidence: 99%

Ratiometric Fluorescent Detection of Ultrasound-Regulated ATP Release: An Ultrasound-Resistant Cu,N-Doped Carbon Nanosphere

Nan

Liu

Shi

et al. 2023

ACS Appl. Mater. Interfaces

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Focused ultrasound, as a protocol of cancer therapy, might induce extracellular adenosine triphosphate (ATP) release, which could enhance cancer immunotherapy and be monitored as a therapeutic marker. To achieve an ATP-detecting probe resistant to ultrasound irradiation, we constructed a Cu/N-doped carbon nanosphere (CNS), which has two fluorescence (FL) emissions at 438 and 578 nm to detect ultrasound-regulated ATP release. The addition of ATP to Cu/N-doped CNS was conducted to recover the FL intensity at 438 nm, where ATP enhanced the FL intensity probably via intramolecular charge transfer (ICT) primarily and hydrogen-bond-induced emission (HBIE) secondarily. The ratiometric probe was sensitive to detect micro ATP (0.2–0.6 μM) with the limit of detection (LOD) of 0.068 μM. The detection of ultrasound-regulated ATP release by Cu,N-CNS/RhB showed that ATP release was enhanced by the long-pulsed ultrasound irradiation at 1.1 MHz (+37%, p < 0.01) and reduced by the short-pulsed ultrasound irradiation at 5 MHz (−78%, p < 0.001). Moreover, no significant difference in ATP release was detected between the control group and the dual-frequency ultrasound irradiation group (+4%). It is consistent with the results of ATP detection by the ATP-kit. Besides, all-ATP detection was developed to prove that the CNS had ultrasound-resistant properties, which means it could bear the irradiation of focused ultrasound in different patterns and detect all-ATP in real time. In the study, the ultrasound-resistant probe has the advantages of simple preparation, high specificity, low limit of detection, good biocompatibility, and cell imaging ability. It has great potential to act as a multifunctional ultrasound theranostic agent for simultaneous ultrasound therapy, ATP detection, and monitoring.

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A Dual Emission Fluorescence Probe Based on Silicon Nanoparticles and Rhodamine B for Ratiometric Detection of Kaempferol

Pan,

Lu,

et al. 2024

J Fluoresc

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Ratiometric fluorescent sensors for nitrite detection in the environment based on carbon dot/Rhodamine B systems

Abstract: A visual ratiometric fluorescent sensor based on blue carbon dot/Rhodamine B is used to selectively detect NO2− in the environment.

Cited by 12 publications

References 52 publications

Advances in Carbon Dot-Based Ratiometric Fluorescent Probes for Environmental Contaminant Detection: A Review

Advances in Carbon Dot-Based Ratiometric Fluorescent Probes for Environmental Contaminant Detection: A Review

Ratiometric Fluorescent Detection of Ultrasound-Regulated ATP Release: An Ultrasound-Resistant Cu,N-Doped Carbon Nanosphere

A Dual Emission Fluorescence Probe Based on Silicon Nanoparticles and Rhodamine B for Ratiometric Detection of Kaempferol

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