Ratiometric fluorescence detection of phosphate in human serum with a metal-organic frameworks-based nanocomposite and its immobilized agarose hydrogels

Gao, Nan; Huang, Jian; Wang, Liyuan; Feng, Jiayu; Huang, Pengcheng; Wu, Fang

doi:10.1016/j.apsusc.2018.08.092

Cited by 79 publications

(31 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relative standard deviation (RSD) was 1.42% (phosphate concentration: 0.1 µmol•L −1 , n = 11). As illustrated in Table 1, compared with currently reported fluorescence methods in the literature [10,[73][74][75][76][77], the linear range and detection limit were superior to other reports. phosphate groups and those from the carboxylate groups on the surface of PCDs for Eu 3+ .…”

Section: Mechanism Of Fluorescent Response To Phosphatementioning

confidence: 78%

Porphin-Based Carbon Dots for “Turn Off–On” Phosphate Sensing and Cell Imaging

Wang

2020

Nanomaterials

View full text Add to dashboard Cite

Porphin-based carbon dots (denoted as PCDs) are prepared through a one-step hydrothermal method by using meso-tetra (4-carboxyphenyl) porphin (TCPP), citric acid, and ethanediamine as precursor. PCDs give rise to the optimal photoluminescence at λex/λem = 375/645 nm, exhibit an excitation-independent property, excellent water solubility, and good biocompatibility, which provide red emission and avoid the autofluorescence as an efficient fluorescent imaging probe. On the other hand, when Eu3+ is added into PCDs, the carboxylate groups located on the surface of PCDs exhibit high affinity to Eu3+, resulting in the fluorescence of PCDs turning off via static quenching. In the presence of phosphate, owing to the strong coordination with Eu3+, the fluorescence of PCDs turns on. Based on this performance, a novel “turn off–on” phosphate sensing system is developed. The detection limit of this sensing system can attain 3.59 × 10−3 μmol L−1. This system has been utilized for the detection of phosphate in real samples successfully, which further demonstrates potential applications in biological diagnostic and environmental analysis.

show abstract

Section: Mechanism Of Fluorescent Response To Phosphatementioning

confidence: 78%

Porphin-Based Carbon Dots for “Turn Off–On” Phosphate Sensing and Cell Imaging

Wang

2020

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Phosphate also plays an important role in regulating homeostasis and participating in enzyme reactions in biological systems. [ 146,147 ] Therefore, the development of an efficient and sensitive method for evaluating phosphate content in water and body fluids is important. Wang et al constructed multiemission UiO‐66@COF composites to achieve ratiometric sensing and visible‐light detection of adenosine‐5′‐triphosphate (ATP) and phosphate ion.…”

Section: Applicationsmentioning

confidence: 99%

Metal–Organic Framework‐Based Hybrid Frameworks

et al. 2020

View full text Add to dashboard Cite

Framework materials, such as metal–organic frameworks (MOFs) and covalent organic frameworks (COFs), offer huge potential for applications in many aspects due to their well‐defined topologies, high crystallinity, inherent porosity, and chemical tunability. One advanced concept of further functionalizing the single framework materials is to construct hybrid frameworks (e.g., MOF‐on‐MOF, MOF‐on‐COF, and COF‐on‐MOF). Herein, different MOF‐based hybrid frameworks with complex compositions and well‐designed structures show excellent properties that cannot be achieved by single framework materials. The synthetic approaches of MOF‐based hybrid frameworks and their related applications are summarized. The opportunities and challenges for MOF‐based hybrid frameworks are also discussed.

show abstract

“…Inorganic phosphate, the second most abundant mineral existing in the human body, − plays a vital role in physiological processes such as preservation of the body’s phosphate balance and homeostasis, energy metabolism, cell signaling and bone mineralization. − Particularly, the amount of phosphate in body fluids (with a normal ratio of H 2 PO 4 – /HPO 4 2– being 1:4 at physiological pH) is used to monitor the health conditions of individual humans. The abnormal content of the phosphate may lead to diseases such as muscle weakness, skeletal dysplasia, cardiovascular complications, hyperparathyroidism, vitamin D deficiency, and Fanconi syndrome. − On the other hand, it has been reported that phosphate pollution in the ground and surface water is a cause for concern in eutrophication. − Importantly, the presence of excess phosphate in the ground and surface water causes rapid reproduction of microorganisms (algae) with depletion in dissolved oxygen, and thus reducing the quality of water and hampering the local ecosystem. − The normal limit of dissolved phosphate in water for good environmental quality is 0.02 mg/L (despite of eutrophication). − The above two requirements themselves make a case for developing rapid and easy detection methods for phosphate.…”

Section: Introductionmentioning

confidence: 99%

A Ratiometric and Visual Sensing of Phosphate by White Light Emitting Quantum Dot Complex

Manna¹,

Roy²,

Bhandari

et al. 2021

Langmuir

View full text Add to dashboard Cite

Ratiometric and visual sensing of phosphate by using a white light emitting quantum dot complex (WLE QDC) is reported herein. The WLE QDC comprised of Mn 2+ -doped ZnS quantum dot (with λ em = 585 nm) and surface zinc quinolate (ZnQS 2 ) complex (with λ em = 480 nm). The limit of detection was estimated to be of 5.9 nM in the linear range of 16.6−82.6 nM. This was accomplished by monitoring the variations in the photoluminescence color, intensity ratio (I 480 /I 585 ), chromaticity and hue of the WLE QDC in the presence of phosphate. The high selectivity and sensitivity of WLE QDC toward phosphate was observed. The chemical interaction of ZnQS 2 (present in WLE QDC) with phosphate might have led to the observed specificity in photoluminescence changes. The presented WLE QDC was successfully employed for the quantification of phosphate in samples prepared using environmental water and commercial fertilizer.

show abstract

Ratiometric fluorescence detection of phosphate in human serum with a metal-organic frameworks-based nanocomposite and its immobilized agarose hydrogels

Cited by 79 publications

References 44 publications

Porphin-Based Carbon Dots for “Turn Off–On” Phosphate Sensing and Cell Imaging

Porphin-Based Carbon Dots for “Turn Off–On” Phosphate Sensing and Cell Imaging

Metal–Organic Framework‐Based Hybrid Frameworks

A Ratiometric and Visual Sensing of Phosphate by White Light Emitting Quantum Dot Complex

Contact Info

Product

Resources

About