Ratio of triglycerides to HDL cholesterol is an indicator of LDL particle size in patients with type 2 diabetes and normal HDL cholesterol levels.

Boizel, R.; Benhamou, Pierre Yves; Lardy, Bernard; Laporte, François; Foulon, T; Halimi, Serge

doi:10.2337/diacare.23.11.1679

Cited by 160 publications

(113 citation statements)

References 30 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The TG and HDL-C ratio has been related to LDL-C size pathophysiology and relevant with regard to the risk of clinical vascular disease. A cut-off value of 1.33 has been reported where >1.33 is suggestive of presence of higher percentage of small LDL particles (14). In our study, this ratio has been found to be 1.00-1.13.…”

Section: Methodssupporting

confidence: 57%

Lipid profile in middle class Bengali population of Kolkata

Goswami

Bandyopadhyay

2003

Indian J Clin Biochem

View full text Add to dashboard Cite

Fasting samples of 1396 apparently healthy, middle class Bengali population of Kolkata, West Bengal were tested for total cholesterol, triglyceddes, high density lipoprotein cholesterol, low density lipoprotein cholesterol and very low density lipoprotein cholesterol, over a pedod of three years. The values obtained were (in mg/dl) 190 + 33, 132 + 42, 53 + 10, 116 :!: 30 and 21 + 7 respectively. When these subjects were grouped according to the age and sex, no appreciable difference were observed between most of the groups. Tdglyceride was found to be low and HDL cholesterol was high in women below 30 years when compared with men of similar age. Beyond 60 years, cholesterol level as well as low density lipoprotein cholesterol was found to be gradually increased in case of women. Besides these changes, other minor differences were not statistically significant. It is suggested that the lipid values of the present study should be taken as a base parameters and the clinical evaluation be made on the basis of these finding. KEY WORDSLipid profile, lipoproteins, lipid triad index, epidemiological study.

show abstract

Section: Methodssupporting

confidence: 57%

Lipid profile in middle class Bengali population of Kolkata

Goswami

Bandyopadhyay

2003

Indian J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…Pioglitazone-induced changes in LDL levels also had some variations: a rise in some reports 13,24) , but not in others, including our studies 16,26) (Table 2). In our study, although LDL-C levels were elevated slightly (not statistically significant) in the pioglitazone group, LDL particle size was increased compared to the baseline ( Table 2), as reported previously 27) . LDL particle size, which is associated with increased risk of cardiovascular diseases 28,29) , decreases with progression from normal individuals to overt type 2 diabetes 30) .…”

Section: Discussionsupporting

confidence: 90%

Effects of Pioglitazone Hydrochloride on Japanese Patients with Type 2 Diabetes Mellitus

Teramoto

Yamada

Shirai

et al. 2007

JAT

View full text Add to dashboard Cite

Aim:The effects of pioglitazone hydrochloride monotherapy on abnormal lipid control were evaluated in Japanese patients with type 2 diabetes mellitus, comparing with glibenclamide monotherapy. Methods: Patients were randomly assigned to receive, once daily, pioglitazone hydrochloride, at 15 mg or 30 mg (n 46), or glibenclamide, at 1.25 mg or 2.5 mg (n 46). The 24-week study included patients with type 2 diabetes having high levels of triglyceride (TG). Results: Pioglitazone hydrochloride produced beneficial effects on dyslipidemia in patients with type 2 diabetes, compared with the baseline and the glibenclamide group, as demonstrated by increases in high-density lipoprotein cholesterol (HDL-C) levels and low-density lipoprotein cholesterol (LDL) particle size, a fall in TG levels, and an increased ratio of visceral to subcutaneous fat volumes (V/S). Pioglitazone hydrochloride reduced fasting serum insulin levels, with low fasting plasma glucose (FPG) and glycohemoglobin levels, compared to the baseline, suggesting an improvement of insulin resistance. Conclusion: As expected, glibenclamide reduced FPG levels through increased insulin secretion. Pioglitazone hydrochloride and glibenclamide were well tolerated. Pioglitazone hydrochloride improved dyslipidemia related to insulin resistance, whereas glibenclamide enhanced insulin secretion, with only a minor effect on lipid control, in Japanese patients with type 2 diabetes.

show abstract

“…TG level and TG/HDL were significantly higher in IFG/IGT but not in iIFG or iIGT compared to NFG/NGT. Increase in TG/HDL is reportedly a good indicator of increase in sdLDL particle [15,16,21]. Hence, the lipid profile in IFG/IGT appears to be very similar to "diabetic dyslipi- demia" in T2DM which is characterized by elevated TG, reduced HDL and predominant presence of sdLDL [3].…”

Section: Discussionmentioning

confidence: 94%