Highlights
Our deep neural network based model represents the first finding of making use of H&E images to predict immunotherapy response.
Area under the curve (AUC) of 0.778(95% confidence interval, 0.638–0.905) was obtained on 54 melanoma H&E samples.
Our model was also validated on a second set of 55 lung cancer samples, yielding an AUC of 0.645 (95% confidence interval, 0.494–0.784), confirming the robustness of this model.