Ratio of “A-type” to “B-type” Proanthocyanidin Interflavan Bonds Affects Extra-intestinal Pathogenic Escherichia coli Invasion of Gut Epithelial Cells

Feliciano, Rodrigo P.; Meudt, Jennifer J.; Shanmuganayagam, Dhanansayan; Krueger, Christian G.; Reed, Jess D.

doi:10.1021/jf403839a

Cited by 77 publications

(93 citation statements)

References 39 publications

(82 reference statements)

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“…However, while in vitro studies have shown dose-response effects of cranberry (poly)phenols on the inhibition of microbial invasion of gut and bladder epithelial cells [8,9] and in the cytotoxicity of ovarian cancer cells [10], very few human dose-response studies have been conducted.…”

Section: Introductionmentioning

confidence: 99%

Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability

et al. 2017

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The beneficial health effects of cranberries have been attributed to their (poly)phenol content. Recent studies have investigated the absorption, metabolism and excretion of cranberry (poly)phenols; however, little is known about whether they follow a dose response in vivo at different levels of intake. An acute double-blind randomized controlled trial in 10 healthy men with cranberry juices containing 409, 787, 1238, 1534 and 1910 mg total (poly)phenols was performed. Blood and urine were analyzed by UPLC-Q-TOF-MS. Sixty metabolites were identified in plasma and urine including cinnamic acids, dihydrocinnamic, flavonols, benzoic acids, phenylacetic acids, benzaldehydes, valerolactones, hippuric acids, catechols, and pyrogallols. Total plasma, but not excreted urinary (poly)phenol metabolites, exhibited a linear dose response (r2 = 0.74, p < 0.05), driven by caffeic acid 4-O-ß-d-glucuronide, quercetin-3-O-ß-d-glucuronide, ferulic acid 4-O-ß-d-glucuronide, 2,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, ferulic acid, caffeic acid 3-O-ß-d-glucuronide, sinapic acid, ferulic acid 4-O-sulfate, 3-hydroxybenzoic acid, syringic acid, vanillic acid-4-O-sulfate, (4R)-5-(3′-hydroxyphenyl)-γ-valerolactone-4′-O-sulfate, 4-methylgallic acid-3-O-sulfate, and isoferulic acid 3-O-sulfate (all r2 ≥ 0.89, p < 0.05). Inter-individual variability of the plasma metabolite concentration was broad and dependent on the metabolite. Herein, we show that specific plasma (poly)phenol metabolites are linearly related to the amount of (poly)phenols consumed in cranberry juice. The large inter-individual variation in metabolite profile may be due to variations in the gut microbiome.

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Section: Introductionmentioning

confidence: 99%

Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability

et al. 2017

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“…Other foods only containing B-type PACs, such as grape seeds or apples, lack these preventive properties against UTI exhibited by cranberry. Cranberry A-type PACs have been shown to exhibit uropathogenic Escherichia coli (UPEC)-anti-adhesive activity and other activities related to bacterial interaction with host cells to a greater extent than B-type PACs (Feliciano, Meudt, Shanmuganayagam, Krueger, & Reed, 2014), but PACs are unlikely to appear in urine at relevant concentrations as they are poorly absorbed in the intestines. One leading hypothesis is that cranberry components, and/or their direct metabolites, present in the urine would operate in the phase of bacterial adherence of UPEC to the uroepithelial cells, preventing bacterial colonization and progression of UTIs (Vasileiou et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Comparative in vitro fermentations of cranberry and grape seed polyphenols with colonic microbiota

et al. 2015

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“…Maki et al [14] who investigated the time to first recurrence did not showed such results. The results of in vitro and in vivo studies suggest that cranberry interferes with the adherence of uropathogenic E. coli to the epithelial cells of the bladder, periurethral region, and intestinal tract [17][18][19][20]. A dose-response relationship of bacterial adhesion to epithelial cells appeared as a result of cranberry consumption [20].…”

Section: Discussion/conclusionmentioning

confidence: 99%

A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (Vaccinium macrocarpon) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis

Bruyère¹,

Azzouzi²,

Lavigne³

et al. 2019

Urol Int

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Objectives: The purpose of the study was to compare the efficacy of a product containing cranberry and propolis (DUAB) to placebo for reducing frequency of cystitis in women with recurrent acute cystitis. Method: A multicenter, placebo-controlled, randomized study of women aged >18 years with at least 4 episodes of cystitis in the previous 12 months was performed. The number of cystitis episodes over a 6-month follow-up was the primary end point. Results: Forty-two women were included in the cranberry + propolis group, and 43 women were in the placebo group. The mean age was 53 ± 18 years, with 6.2 ± 3.6 cystitis episodes in the previous year, with no differences between the 2 groups. The mean number of infections was lower in the propolis + cranberry group (respectively, 2.3 ± 1.8 vs. 3.1 ± 1.8). The total number of cystitis episodes in the first 3 months was lower in the propolis + cranberry group (0.7 ± 1.1 vs. 1.3 ± 1.1, p = 0.0257) after adjusting for water consumption. The mean time to onset of the first urinary tract infection (UTI) was also significantly longer in the propolis + cranberry group (69.9 ± 45.8 days vs. 43.3 ± 45.9, p = 0.0258). Tolerance to the treatments was good and comparable in both groups. Conclusions: We demonstrate for the first time that cranberry and propolis supplementation significantly reduces the incidence of UTIs during the first 3 months and delays the onset of an episode of cystitis.

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Ratio of “A-type” to “B-type” Proanthocyanidin Interflavan Bonds Affects Extra-intestinal Pathogenic Escherichia coli Invasion of Gut Epithelial Cells

Cited by 77 publications

References 39 publications

Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability

Absorption, Metabolism and Excretion of Cranberry (Poly)phenols in Humans: A Dose Response Study and Assessment of Inter-Individual Variability

Comparative in vitro fermentations of cranberry and grape seed polyphenols with colonic microbiota

A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (<b><i>Vaccinium macrocarpon</i></b>) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis

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