Read not to contradict and confute, nor to believe and take for granted . . . but to weigh and consider." -Francis Bacon A highly promoted element of evidence-based practice (EBP) is the Strength of Recommendation (SOR). The SOR is usually a letter grade (A, B, or C) and is a composite mark based on the quantity, quality, nature, and consistency of the external evidence. These SOR grades are most conspicuous to readers who are consuming Critically Appraised Topics (CATs) and Systematic Reviews, as well as Position Statements and Consensus Statements. The Strength of Recommendation Taxonomy (SORT) 1 was developed by a consortium of family medicine physicians, and was designed to help clinicians rate the available external evidence (research) when used for clinical decision-making. Patientoriented evidence-outcomes that were selected because of their direct impact on patients-is considered more favorable when compared to disease-oriented evidence. 2 (For a quick review on patient-oriented vs. disease-oriented evidence, see Table 1.) Additionally, studies that tend to limit the threats to internal validity (studies that have low risk of bias) are also considered more favorable than studies with more risk of bias. 2 Ultimately, from the SOR perspective, evidence that is generated from patientoriented outcomes, and has little risk of bias, is ranked higher. Finally, there are elements of quantity and consistency that have to be incorporated into the SOR grade. The SOR grade is not created in the vacuum of a single study. The more studies that are included and the more studies included that "say the same thing" will also enhance the SOR grade. Briefly, the SOR is generated through a synthesis of the (1) quantity of external evidence used to answer a clinical question, (2) quality of the external evidence, (3) nature of the outcomes of interest, and (4) consistency of the results.Before we go into what the SOR means, we will quickly outline these four SOR inputs (see Figure 1):1. The quantity of the external evidence:One of the hallmarks of scientific research is the reproducibility of results, especially through independent investigations. In general, the SOR is based on more than one research study. In other words, "all" of the studies that address a particular research question are taken into account to generate the SOR grade. Multiple investigations on independent samples that all come from the same population of interest help to paint a clearer picture of the actual behavior likely found in that population. With quantity of the external evidence, more is better. . . but, not the only determining factor. 2. The quality of the external evidence:As we have outlined in past editorials and papers, 3,4 study designs can be ranked on a hierarchy that is based on potential bias that might be introduced by investigators. These biases can alter the interpretation of the internal and external validity of that study. There is an appreciable balancing act between control (internal validity) and generalizability (external vali...