Rating chronic medical illness burden in geropsychiatric practice and research: Application of the Cumulative Illness Rating Scale

Miller, Mark D.; Paradis, Cynthia F.; Houck, Patricia R.; Mazumdar, Sati; Stack, Jacqueline A.; Rifai, A. Hind; Mulsant, Benoit H.; Reynolds, Charles F.

doi:10.1016/0165-1781(92)90005-n

Cited by 1,746 publications

(1,185 citation statements)

References 17 publications

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“…Comorbid conditions are frequent in NSCLC patient populations, considering the mean age and the high frequency of smokers of this population. Comorbidities are considered as an important prognostic factor in patients with different types of cancer, including lung cancer (Feinstein et al, 1977;Wells et al, 1984;Clemens et al, 1986;Feinstein and Wells, 1990;Miller et al, 1992;Waldman and Potter, 1992;Piccirillo et al, 1994;Satariano and Ragland, 1994;Piccirillo and Feinstein, 1996;Rochon et al, 1996;Pugliano et al, 1997;Singh et al, 1997;Extermann et al, 1998;Firat et al, 2002a). Comorbidities may impair survival by themselves or by affecting the therapeutic options.…”

Section: Discussionmentioning

confidence: 99%

A new simplified comorbidity score as a prognostic factor in non-small-cell lung cancer patients: description and comparison with the Charlson's index

et al. 2005

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Treatment of non-small-cell lung cancer (NSCLC) might take into account comorbidities as an important variable. The aim of this study was to generate a new simplified comorbidity score (SCS) and to determine whether or not it improves the possibility of predicting prognosis of NSCLC patients. A two-step methodology was used.Step 1: An SCS was developed and its prognostic value was compared with classical prognostic determinants in the outcome of 735 previously untreated NSCLC patients.Step 2: the SCS reliability as a prognostic determinant was tested in a different population of 136 prospectively accrued NSCLC patients with a formal comparison between SCS and the classical Charlson comorbidity index (CCI). Prognosis was analysed using both univariate and multivariate (Cox model) statistics. The SCS summarised the following variables: tobacco consumption, diabetes mellitus and renal insufficiency (respective weightings 7, 5 and 4), respiratory, neoplastic and cardiovascular comorbidities and alcoholism (weighting ¼ 1 for each item). In step 1, aside from classical variables such as age, stage of the disease and performance status, SCS was a statistically significant prognostic variable in univariate analyses. In the Cox model weight loss, stage grouping, performance status and SCS were independent determinants of a poor outcome. There was a trend towards statistical significance for age (P ¼ 0.08) and leucocytes count (P ¼ 0.06). In Step 2, both SCS and well-known prognostic variables were found as significant determinants in univariate analyses. There was a trend towards a negative prognostic effect for CCI. In multivariate analysis, stage grouping, performance status, histology, leucocytes, lymphocytes, lactate dehydrogenase, CYFRA 21-1 and SCS were independent determinants of a poor prognosis. CCI was removed from the Cox model. In conclusion, the SCS, constructed as an independent prognostic factor in a large NSCLC patient population, is validated in another prospective population and appears more informative than the CCI in predicting NSCLC patient outcome.

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Section: Discussionmentioning

confidence: 99%

A new simplified comorbidity score as a prognostic factor in non-small-cell lung cancer patients: description and comparison with the Charlson's index

et al. 2005

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“…We assessed depression severity with the 17-item Hamilton Rating Scale for Depression (24); comorbid physical illness with the Cumulative Illness Rating Scale adapted for Geriatrics (25); and level of hopelessness with the Beck Hopelessness Scale (26). We obtained medication lists from pharmacy records to assess physical illness burden and psychotropic medication exposure.…”

Section: Methodsmentioning

confidence: 99%

Impaired Executive Function in Contemplated and Attempted Suicide in Late Life

Gujral

Dombrovski

Butters

et al. 2014

The American Journal of Geriatric Psychiatry

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Objective Executive deficits may play an important role in late-life suicide. Yet, current evidence in this area is inconclusive and does not indicate whether these deficits are broadly associated with suicidal ideation or specific to suicidal behavior. This study examined global cognition and specifically executive function impairments as correlates of suicidal ideation and suicidal behavior in depressed older adults, with the goal of extending an earlier preliminary study. Design Case-control study. Setting University-affiliated psychiatric hospital. Participants All were aged 60+: 83 depressed suicide attempters, 43 depressed individuals having suicidal ideation with a specific plan, 54 non-suicidal depressed participants, and 48 older adults with no history of psychiatric disorders. Measurements Global cognitive function - Dementia Rating Scale (DRS), Executive function - Executive Interview (EXIT). Results Both suicide attempters and suicide ideators performed worse than the two comparison groups on the EXIT, with no difference between suicide attempters and suicide ideators. On the DRS total score, as well as on Memory and Attention subscales, suicide attempters and ideators and non-suicidal depressed subjects performed similarly and were impaired relative to with non-psychiatric control subjects. Controlling for education, substance use disorders, and medication exposure did not affect group differences in performance on either the EXIT or DRS. Conclusions Executive deficits, captured with a brief instrument, are associated broadly with suicidal ideation in older depressed adults but do not appear to directly facilitate suicidal behavior. Our data are consistent with the idea that different vulnerabilities may operate at different stages in the suicidal process.

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“…Higher scores indicate more symptoms of depression. The comorbidity questionnaire was based on the Cumulative Illness Rating Scale-Geriatrics (Fernández-Mayoralas et al 2007;Miller et al 1992) and the number of self-reported medical conditions was taken for the current study. The questionnaire explores the presence (yes/no) of 20 medical conditions plus an open question for ''others.''…”

Section: Methodsmentioning

confidence: 99%

Components and determinants of quality of life in community-dwelling older adults

et al. 2012

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The objectives of this study are to detect the main components of global quality of life (QoL) of community-dwelling older adults from their own perspective and to identify determinants of health-related and global QoL in the same population. This is a cross-sectional study covering a representative sample of 1,106 communitydwelling adults aged 60 years and older residing in Spain. The survey collected information on QoL through a face-toface interview asking for QoL components in free-format, as well as the completion of two QoL measures, the EQ-5D and the Personal Wellbeing Index. The most important QoL dimensions, according to the participants of this study, were health, family, and finances. Depression was the main determinant of both QoL indices, while functional independence and social support specifically influenced health-related and global QoL, respectively. Based on the perspective of the older adults as well as on statistical analysis, this work emphasizes the importance of health, family, and social support as areas of special interest in aging. There was a discrepancy when comparing findings related to the importance of financial status. Results also support that global and health-related QoL share some common determinants, but with different weights for functional independence and social support.Keywords Global quality of life Á Health-related quality of life Á Community-dwelling Á Older adults Á Multimethod data

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Rating chronic medical illness burden in geropsychiatric practice and research: Application of the Cumulative Illness Rating Scale

Cited by 1,746 publications

References 17 publications

A new simplified comorbidity score as a prognostic factor in non-small-cell lung cancer patients: description and comparison with the Charlson's index

A new simplified comorbidity score as a prognostic factor in non-small-cell lung cancer patients: description and comparison with the Charlson's index

Impaired Executive Function in Contemplated and Attempted Suicide in Late Life

Components and determinants of quality of life in community-dwelling older adults

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