Rates of Depression in Individuals With Pathologic But Not Clinical Alzheimer Disease are Lower Than Those in Individuals Without the Disease: Findings From the Baltimore Longitudinal Study on Aging (BLSA)

Morgan, Melissa; Mielke, Michelle M.; O’Brien, Richard; Troncoso, Juan C.; Zonderman, Alan B.

doi:10.1097/wad.0b013e3181461932

Cited by 13 publications

(8 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression Scale. Individuals with Alzheimer’s pathology but without cognitive decline had significantly lower rates of depression than cognitively normal individuals with no Alzheimer’s pathology and individuals with Alzheimer’s pathology plus clinical diagnosis of dementia (Morgan et al, 2007). In a population-based study, 1241 participants, aged 62–85 years, were asked about their physical activity during their early adult years.…”

Section: Differences In Cognitive Agingmentioning

confidence: 99%

Memory Performance and Affect: Are there Gender Differences in Community-Residing Older Adults?

McDougall

Pituch

Stanton

et al. 2014

Issues in Mental Health Nursing

View full text Add to dashboard Cite

After age 65, the incidence of episodic memory decline in males is greater than in females. We explored the influence of anxiety and depression on objective and subjective memory performance in a diverse sample of community-residing older adults. The study was a secondary analysis of data on three samples of adults from two states, Ohio and Texas: a community sample (n = 177); a retirement community sample (n = 97); and the SeniorWISE Study (n = 265). The sample of 529 adults was 74% female, the average age was 76.58 years (range = 59-100 years), and educational attainment was 13.12 years (±3.68); 68% were Caucasian, and 17% had depressive symptoms. We found no memory performance differences by gender. Males and females were similarly classified into the four memory performance groups, with almost half of each gender in the poor memory category. Even though males had greater years of education, they used fewer compensatory memory strategies. The observed gender differences in memory were subjective evaluations, specifically metamemory. Age was not a significant predictor of cognition or memory performance, nor did males have greater memory impairment than females.

show abstract

Section: Differences In Cognitive Agingmentioning

confidence: 99%

Memory Performance and Affect: Are there Gender Differences in Community-Residing Older Adults?

McDougall

Pituch

Stanton

et al. 2014

Issues in Mental Health Nursing

View full text Add to dashboard Cite

show abstract

“…A second clinical study focused on the rates of depressive symptoms in individuals with asymptomatic AD [34]. The prevalence of major depression is increased in AD, but the basis of this association remains unclear.…”

Section: Clinical Studies Of Preclinical/asymptomatic Alzheimer’s Dismentioning

confidence: 99%

Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)

O’Brien

Resnick

Zonderman

et al. 2009

JAD

Self Cite

122

115

View full text Add to dashboard Cite

The Baltimore Longitudinal Study of Aging (BLSA) was established in 1958 and is one the oldest prospective studies of aging in the USA and the world. The BLSA is supported by the National Institute of Aging (NIA) and its mission is to learn what happens to people as they get old and how to sort out changes due to aging and from those due to disease or other causes. In 1986, an autopsy program combined with comprehensive neurologic and cognitive evaluations was established in collaboration with the Johns Hopkins University Alzheimer’s Disease Research Center (ADRC). Since then, 211 subjects have undergone autopsy. Here we review the key clinical neuropathological correlations from this autopsy series. The focus is on the morphological and biochemical changes that occur in normal aging, and the early neuropathological changes of neurodegenerative diseases, especially Alzheimer’s disease (AD). We highlight the combined clinical, pathologic, morphometric, and biochemical evidence of asymptomatic AD, a state characterized by normal clinical evaluations in subjects with abundant AD pathology. We conclude that in some individuals, successful cognitive aging results from compensatory mechanisms that occur at the neuronal level (i.e., neuronal hypertrophy and synaptic plasticity) whereas a failure of compensation may culminate in disease.

show abstract

“…A recent U.S. study concluded that 22% of adults over the age of 71 might have MCI (Plassman et al, 2008). Since the number of new cases of Alzheimer’s Disease (AD) is expected to increase 3-fold to 13.2 million by 2050, the development of preventive interventions is urgent (Hebert, Scherr, Bienias, Bennett, & Evans, 2003; Morgan et al, 2007). …”

mentioning

confidence: 99%

The SeniorWISE Study: Improving Everyday Memory in Older Adults

McDougall¹,

Becker²,

Pituch³

et al. 2010

Archives of Psychiatric Nursing

View full text Add to dashboard Cite

We tested whether at-risk older adults receiving memory training showed better memory self-efficacy, metamemory, memory performance, and function in instrumental activities of daily living than participants receiving a health promotion training comparison condition. We followed participants for 26 months. The sample was mostly female (79%) and Caucasian (71%), with 17% Hispanics, and 12% African Americans; average age was 75 years and average education was 13 years. The memory training group made greater gains on global cognition and had fewer memory complaints, but both groups generally maintained their performance on the other cognitive measures and IADLs throughout the 24-month study period. Black and Hispanic participants made greater gains than Whites did on some memory performance measures but not on memory self-efficacy. The unexpected finding that minority elders made the largest gains merits further study. This study contributed to the knowledge base of geropsychiatric nursing by providing evidence for an effective psychosocial intervention that could be delivered by advanced practice nurses. Trial Registration ClinicalTrials.gov NCT00094731

show abstract

Rates of Depression in Individuals With Pathologic But Not Clinical Alzheimer Disease are Lower Than Those in Individuals Without the Disease: Findings From the Baltimore Longitudinal Study on Aging (BLSA)

Cited by 13 publications

References 41 publications

Memory Performance and Affect: Are there Gender Differences in Community-Residing Older Adults?

Memory Performance and Affect: Are there Gender Differences in Community-Residing Older Adults?

Neuropathologic Studies of the Baltimore Longitudinal Study of Aging (BLSA)

The SeniorWISE Study: Improving Everyday Memory in Older Adults

Contact Info

Product

Resources

About