Rates of 5 Common Antidepressant Side Effects Among New Adult and Adolescent Cases of Depression: A Retrospective US Claims Study

Anderson, Heather; Pace, Wilson D.; Libby, Anne M.; West, D. R. F.; Valuck, Robert J.

doi:10.1016/j.clinthera.2011.11.024

Cited by 119 publications

(79 citation statements)

References 27 publications

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“…Another study has determined that 22% of the patients who had an antidepressant treatment did not comply with the treatment because of the problems, such as weight gain, sexual dysfunction, lack of sexual desire, and weakness (10). The most common side effects of the antidepressant treatments were also headache and nausea (9).…”

Section: Discussionmentioning

confidence: 99%

“…Investigators prepared an information form for the patients, which was in line with the relevant literature (2,3,9,(16)(17)(18). The information form contained 33 questions referring the demographic characteristics of the patients, such as the age, gender, and education status and other characteristics, such as visiting a psychiatrist, antidepressant use, and encountered side effects.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Determination of Antidepressant Drug Use among Inpatients in Medical and Surgical Clinics

Ata¹,

Yılmaz²

2017

Clin Exp Health Sci

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Objective: This cross-sectional study was performed to determine antidepressant drug use among inpatients in medical and surgical clinics. Methods: The study sample consisted of 478 inpatients from a state hospital, between December 1, 2015 and January 1, 2016. The information form was applied to the patients. Number and percentage distribution were used for data analysis. Results: Of the 478 patients, 34.5% had visited a psychiatrist once in their lifetime, 13.6% were diagnosed with depression, and 13.8% did not know the diagnosis of mental disease; 32.2% were suggested medication by their doctor, 16.7% did not know the name of this medication, and 13.2% stated that the suggested drug was antidepressant. Moreover, 24.9% of the patients were known to use antidepressant at least once in their lifetime, and 16.3% were still using antidepressants. Among patients using antidepressants, 32% continued using this drug upon doctor's recommendation and 13.6% continued with the diagnosis of depression. Conclusion: It might be concluded that one-fourth of the patients used antidepressant once in their lifetime; more than one-half of these patients were still using antidepressants, and most of them were using the drug upon doctor's recommendation without any knowledge about antidepressants.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Determination of Antidepressant Drug Use among Inpatients in Medical and Surgical Clinics

Ata¹,

Yılmaz²

2017

Clin Exp Health Sci

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“…Aikens et al (2005) [35] found patient skepticism towards antidepressant therapy was a strong predictor of discontinuation. Medication side-effects, the most common of which are headache and nausea [9], have also been shown to be associated with premature discontinuation of antidepressants [9,[31][32][33][34][35].…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

“…Patients may also discontinue due to an inadequate response to their initial treatment [7], without implementation of appropriate alternative second-step treatment strategies [8]. Furthermore, patients may be noncompliant with their medication or discontinue because of adverse side effects [9,10]. If we are to assess the potential unmet need in antidepressant treatment, it is per-tinent to examine patterns of therapy discontinuation and associated factors.…”

Section: Introductionmentioning

confidence: 99%

Discontinuation of antidepressant therapy among patients with major depressive disorder

Davé¹,

Classi²,

Le³

et al. 2012

OJPsych

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Objective: Patients with major depressive disorder (MDD) often discontinue antidepressant therapy prematurely risking relapse, despite United Kingdom (UK) guidelines recommending therapy for up to at least six months after remission. More information is needed on the patterns of antidepressant discontinuation in UK primary care. Objectives of the study were to assess the patterns, incidence and predictors of therapy discontinuation among MDD patients initiating treatment with selective serotonin reuptake inhibitors (SSRIs). Methods: This was a retrospective cohort study using general practices registered with the General Practice Research Database (GPRD). 15,274 patients with MDD receiving a first ever prescription (index) for an SSRI between 2006-2008 were identified in GPRD. Discontinuation (including temporary gaps) and cessation of antidepressant therapy were examined over follow-up. Predictors of incidence of discontinuation in the six months after index were assessed. Results: Incidence of discontinuation of antidepressant therapy over follow-up was 80.05 per 100 person years (95% CI 78.94 -81.17). At six months after index 42% of patients had discontinued and 33% had ceased therapy altogether. Lower discontinuation of index SSRI therapy in the first six months after initiation was associated with higher age, higher body mass index (BMI), and comorbid irritable bowel syndrome. Higher discontinuation was associated with paroxetine or fluoxetine at index, and a more recent index calendar year. Conclusions: There is a significant risk of discontinuation of antidepressant therapy in the 6 months after initiation of treatment for MDD. This finding requires awareness by the general practitioner (GP) to ensure implementation of optimal treatment regimens, and minimization of therapy non-compliance among MDD patients.

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“…The antidepressant drugs are a class of neuroactive compounds that act as selective serotonin reuptake inhibitors and serotonin noradrenergic reuptake inhibitors, and some of their metabolites also retain the pharmacologic activity and are capable of contributing to serotonin reuptake inhibition [6][7][8]. The unaltered drugs or their main metabolites have been detected in municipal wastewaters in many countries [9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Metagenomic Profi ling of Antibiotic Resistance Genes and Mobile Genetic Elements in a Tannery Wastewater Treatment Plant

2015

Wastewater and Public Health

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Antidepressants are a new kind of pollutants being increasingly found in wastewater. In this study, a fast and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry method was developed and validated for the analysis of 24 antidepressant drugs and six of their metabolites in wastewater. This is the first time that the antidepressant residues in wastewater of Beijing (China) were systematically reported. A solid-phase extraction process was performed with 3 M cation disk, followed by ultra-high performance liquid chromatography-tandem mass spectrometry measurements. The chromatographic separation and mass parameters were optimized in order to achieve suitable retention time and good resolution for analytes. All compounds were satisfactorily determined in one single injection within 20 min. The limit of quantification (LOQ), linearity, and extraction recovery were validated. The LOQ for analytes were ranged from 0.02 to 0.51 ng/mL. The determination coefficients were more than 0.99 within the tested concentration range (0.1-25 ng/mL), and the recovery rate for each target compound was ranged from 81.2% to 118% at 1 ng/mL. This new developed method was successfully applied to analysis the samples collected from Beijing municipal

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Rates of 5 Common Antidepressant Side Effects Among New Adult and Adolescent Cases of Depression: A Retrospective US Claims Study

Cited by 119 publications

References 27 publications

Determination of Antidepressant Drug Use among Inpatients in Medical and Surgical Clinics

Determination of Antidepressant Drug Use among Inpatients in Medical and Surgical Clinics

Discontinuation of antidepressant therapy among patients with major depressive disorder

Metagenomic Profi ling of Antibiotic Resistance Genes and Mobile Genetic Elements in a Tannery Wastewater Treatment Plant

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