Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational study

Hankey, Graeme J.; Anderson, Neil E.; Ting, Robert; Veillard, Anne Sophie; Romo, Matti; Wosik, Melinda; Sullivan, David; O’Connell, Rachel; Hunt, David; Keech, Anthony

doi:10.1136/jnnp-2012-303365

Cited by 49 publications

(70 citation statements)

References 23 publications

(11 reference statements)

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“…[7][8][9]16,17 However, none of the previous studies has specifically examined the association between glycated hemoglobin and stroke risk in diabetic patients with atrial fibrillation. Glycated hemoglobin was also found to be associated with increased risk of ischemic stroke in non-diabetic patients.…”

Section: Discussionmentioning

confidence: 97%

Glycated hemoglobin and risk of first episode stroke in diabetic patients with atrial fibrillation: A cohort study

et al. 2015

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Section: Discussionmentioning

confidence: 97%

Glycated hemoglobin and risk of first episode stroke in diabetic patients with atrial fibrillation: A cohort study

et al. 2015

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“…The finding of an increased risk of ischemic stroke in patients with diabetic retinopathy is consistent with previous studies (13, 16). A prospective study also suggests that diabetic retinopathy is an independent risk for small arterial stroke (20). It is believed that the change of retinal vasculature reflects the change of small vessels intracranially.…”

Section: Discussionmentioning

confidence: 99%

Microvascular Parameters Help to Predict Stroke Risk in the Asian Diabetic Population in Taiwan: A Population Based Case-Control Study

Lo¹,

Chen²,

Muo³

et al. 2018

Front. Neurol.

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Intensive glycemic control has not shown consistent findings in stroke prevention for diabetes patients, particularly for those with microvascular complications. This case-control study evaluates the risks of stroke in Asian diabetic population with microvascular complications. From the insurance claims of Taiwan, we identified 67,426 type 2 diabetic mellitus (DM) patients with newly diagnosed stroke in 2000–2011 and 134,852 randomly selected controls with DM but without stroke, matched by sex, age, and number of years since diagnosis of DM. Conditional logistic regression analysis measured crude odds ratios (OR) and adjusted odds ratio (aOR) of stroke and 95% confidence intervals (CI) for associations with demographic status, comorbidities, and microvascular complications: retinopathy (RetP), neuropathy (NeuP) or nephropathy (NepP). The aOR of stroke increased significantly associated with each complication: 1.47 with RetP, 1.73 with NeuP and 1.23 with NepP. The risk increased further when there was a combination of complications. The overall aOR of stroke was 2.83 (95% CI 2.58–3.09) for stroke patients with 3 microvascular complications. The corresponding aOR of ischemic stroke was 2.64 (95% CI 2.39–2.91) and that of hemorrhagic stroke was 4.12 (95% CI 3.25–5.22). The number of microvascular complications positively correlated to the prevalence of comorbidity (p < 0.01). This study suggests that microvascular complications are significant stroke predictors, with a greater involvement for ischemic stroke than for hemorrhagic stroke. Multiple microvascular complications interactively increase the stroke risk. Our study contributes to the identification of high-risk subjects for stroke prevention and adequate glycemic control.

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“…Primarily involved in the coagulation cascade, fibrinogen levels increase during inflammation, with high levels known to increase risk of coronary artery disease [4] and stroke [5]. Clearly materials design must be considering for those in contact with fibrinogen containing biofluids, particularly where thrombus formation could result in major adverse pathology.…”

Section: Conference Papers In Sciencementioning

confidence: 99%

Dynamic Assessment of Fibrinogen Adsorption and Secondary Structure Perturbation

Khot

Kuforiji

Wright

et al. 2014

Conference Papers in Science

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Fibrinogen is a protein being of prime importance for the initiation of clotting and thrombus formation, readily adsorbed onto surfaces presenting both hydrophilic and hydrophobic nature. The mechanism of adsorption, and thus the final presentation of this protein are therefore important for subsequent involvement for, for example, platelet adhesion. Biological activity can be controlled through careful consideration of material design; here we report kinetic assessment of fibrinogen adsorption onto plasma polymerised allylamine (hydrophilic) and hexane (hydrophobic) surfaces, using FTIR-ATR to inform on kinetics of adsorption, secondary structure evaluation, and orientational variation. Fibrinogen was found to respond differently to these two surfaces, adsorbing more rapidly to hydrophilic surfaces and losing an ordered secondary structure over a much longer timescale compared to hydrophobic surfaces.

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Rates and predictors of risk of stroke and its subtypes in diabetes: a prospective observational study

Abstract: Background

Cited by 49 publications

References 23 publications

Glycated hemoglobin and risk of first episode stroke in diabetic patients with atrial fibrillation: A cohort study

Glycated hemoglobin and risk of first episode stroke in diabetic patients with atrial fibrillation: A cohort study

Microvascular Parameters Help to Predict Stroke Risk in the Asian Diabetic Population in Taiwan: A Population Based Case-Control Study

Dynamic Assessment of Fibrinogen Adsorption and Secondary Structure Perturbation

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