Rate, risk factors and outcomes of catheter-related bloodstream infection in a paediatric intensive care unit in Saudi Arabia

Almuneef, Maha; Memish, Ziad A.; Balkhy, HH; Hijazi, Omar; Cunningham, Gwen; Francis, Christine

doi:10.1016/j.jhin.2005.06.032

Cited by 112 publications

(88 citation statements)

References 20 publications

(29 reference statements)

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“…Abstracts for which there was no agreement as to the inclusion were analyzed jointly and the decision was made by consensus. Thus, 84 (80 articles and four theses) were ob-tained for detailed reading by the same two authors independently 27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,…”

Section: Methodsmentioning

confidence: 99%

“…The upper age limit found was 18 years. In these studies, the main outcomes were hospital infection in any site 50,51,52,54 , laboratory-confirmed bloodstream infection 55,56,57 , lower respiratory tract infection 58,59,60 and urinary tract infection 49 . All but one article 49 achieved the maximum score of the Newcastle-Ottawa Scale for cohort studies.…”

Section: Description and Quality Of Studiesmentioning

confidence: 99%

“…Three studies assessed risk factors for bloodstream infection -Laboratory-confirmed bloodstream infection (BSI-LCBI) 55,56,57 , two of them included only patients with central venous access 55,56 . The BSI-LCBI rate (Table 1) ranged from 4.2 to 9.98%.…”

Section: Bloodstream Infection As Outcomementioning

confidence: 99%

“…Amongst intrinsic factors, underlying disease and age showed no statistical significance, whereas genetic syndrome remained in the model by Elward et al 57 . Elward et al 57 studied the use of central venous access as an extrinsic risk factor for bloodstream infection, whereas this variable was an inclusion criterion in the studies by Odetola et al 55 and Almuneef et al 56 . The use of multiple catheters and parenteral nutrition were found to be significant risk factors for Almuneef et al 56 .…”

Section: Bloodstream Infection As Outcomementioning

confidence: 99%

“…Elward et al 57 studied the use of central venous access as an extrinsic risk factor for bloodstream infection, whereas this variable was an inclusion criterion in the studies by Odetola et al 55 and Almuneef et al 56 . The use of multiple catheters and parenteral nutrition were found to be significant risk factors for Almuneef et al 56 . Only Elward et al 57 assessed the number of packed red blood cell transfusions and they found that a high number was a significant risk factor.…”

Section: Bloodstream Infection As Outcomementioning

confidence: 99%

See 4 more Smart Citations

Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

et al. 2009

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Section: Methodsmentioning

confidence: 99%

Section: Description and Quality Of Studiesmentioning

confidence: 99%

Section: Bloodstream Infection As Outcomementioning

confidence: 99%

Section: Bloodstream Infection As Outcomementioning

confidence: 99%

Section: Bloodstream Infection As Outcomementioning

confidence: 99%

See 3 more Smart Citations

Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

et al. 2009

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Development of a clinical practice guideline for weaning and discontinuing parenteral nutrition in hospitalized children as part of a central line–associated bloodstream infection–focused quality improvement initiative

Pulido

Kellogg

Hunt

et al. 2021

J Parenter Enteral Nutr

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Background: Overprescribing of parenteral nutrition (PN) increases costs and risks to patients, including from central line-associated bloodstream infection (CLABSI). With CLABSI reduction in mind, our children's hospital began an iterative quality improvement effort to decrease PN utilization by first ensuring appropriate initiation and then defining and ensuring appropriate discontinuation.Methods: Education was launched along with audits to evaluate for appropriate PN indications. Next, a literature review was conducted to guide the development of an algorithm to appropriately wean and discontinue PN. Lastly, all PN discontinuations were audited for agreement with the new guideline. Retrospectively, monthly PN utilization index (orders per patient-day) was plotted on a statistical process control chart to assess change over time. The presence of PN as a risk factor for CLABSI events and the overall hospital CLABSI rate were trended. Results:Mean PN utilization index fell from 0.156 (July 2018 to January 2019) to 0.12 (February 2019 to August 2020) (P < .01). For 18 months, no PN utilization index reached the baseline lower control limit of 0.144, demonstrating special-cause variation and sustained change. PN as a risk factor for hospital CLABSI cases decreased from most prevalent (49% of cases) to fifth most prevalent (29%) as the CLABSI rate trended down. Conclusion: Engaging frontline staff in the development of a clinical practice guidelineand increased accountability to reduce potential patient harm led to a significant and sustained reduction in PN utilization, as well as decreased prevalence of PN as a risk factor in hospital CLABSI cases.

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Catheter-Related Infections in Pediatric Parenteral Nutrition in Intensive Care Unit

Vivanco-Allende¹,

Rey²,

Concha³

et al. 2015

Diet and Nutrition in Critical Care

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Rate, risk factors and outcomes of catheter-related bloodstream infection in a paediatric intensive care unit in Saudi Arabia

Cited by 112 publications

References 20 publications

Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

Risk factors for healthcare-associated infection in pediatric intensive care units: a systematic review

Development of a clinical practice guideline for weaning and discontinuing parenteral nutrition in hospitalized children as part of a central line–associated bloodstream infection–focused quality improvement initiative

Catheter-Related Infections in Pediatric Parenteral Nutrition in Intensive Care Unit

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