Rate of Second Primary Head and Neck Cancer With Cannabis Use

Kim, Jeehyun; Hua, Gordon; Zhang, Han; Chan, Teffran J.; Xie, Michael; Levin, Marc; Farrokhyar, Forough; Archibald, Stuart; Jackson, B. Stanley; Young, James K.; Gupta, Michael

doi:10.7759/cureus.11483

Cited by 5 publications

(8 citation statements)

References 13 publications

(19 reference statements)

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“…6 Additionally, we demonstrated that among certain HNC patients, MM poses no risk to patient survival and does not increase the incidence of secondary HNC primaries. 7,8 A patient's perspectives and attitudes toward MM may influence their decision to inquire about and use MM. Additionally, unlike other novel therapeutic agents, most patients are aware of and have certain preconceived opinions regarding MM.…”

Section: Introductionmentioning

confidence: 99%

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Attitudes Toward and Acceptability of Medical Marijuana Use Among Head and Neck Cancer Patients

Levin

Zhang

Gupta

2022

Ann Otol Rhinol Laryngol

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Objective: This study aims to understand the attitudes toward marijuana in HNC patients. Methods: A 17-question questionnaire regarding medical marijuana (MM) was distributed to HNC patients at a tertiary cancer center. Results: 63 HNC patients completed the questionnaire. Patients that had used or were using marijuana described benefit with symptoms of headache, pain, nausea, and loss of appetite. 83% of all patients considered marijuana as treatment for cancer related pain and 67% as treatment for cancer related anxiety. About 70% of patients actively undergoing cancer treatment believed marijuana medications would help with symptoms during treatment. Conclusions: By understanding how HNC patients perceive MM, HNC teams may be able to prescribe and educate their patients on MM.

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Section: Introductionmentioning

confidence: 99%

“…6 Additionally, we demonstrated that among certain HNC patients, MM poses no risk to patient survival and does not increase the incidence of secondary HNC primaries. 7,8…”

Section: Introductionmentioning

confidence: 99%

Attitudes Toward and Acceptability of Medical Marijuana Use Among Head and Neck Cancer Patients

Levin

Zhang

Gupta

2022

Ann Otol Rhinol Laryngol

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“…The relationship between cannabinoids and the pathogenesis of oral cancer is complex and marked by contradictory findings. Early epidemiological studies suggest a higher incidence of head and neck cancers linked to marijuana use, particularly among younger individuals, with dose-response associations [78,95,100]. In the initial studies, tobacco smoking and alcohol were identified as cofactors.…”

Section: Discussionmentioning

confidence: 99%

Role of Cannabinoids in Oral Cancer

Cretu,

Zamfir,

Bucurica

et al. 2024

IJMS

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Cannabinoids have incited scientific interest in different conditions, including malignancy, due to increased exposure to cannabis. Furthermore, cannabinoids are increasingly used to alleviate cancer-related symptoms. This review paper aims to clarify the recent findings on the relationship between cannabinoids and oral cancer, focusing on the molecular mechanisms that could link cannabinoids with oral cancer pathogenesis. In addition, we provide an overview of the current and future perspectives on the management of oral cancer patients using cannabinoid compounds. Epidemiological data on cannabis use and oral cancer development are conflicting. However, in vitro studies assessing the effects of cannabinoids on oral cancer cells have unveiled promising anti-cancer features, including apoptosis and inhibition of cell proliferation. Downregulation of various signaling pathways with anti-cancer effects has been identified in experimental models of oral cancer cells exposed to cannabinoids. Furthermore, in some countries, several synthetic or phytocannabinoids have been approved as medical adjuvants for the management of cancer patients undergoing chemoradiotherapy. Cannabinoids may improve overall well-being by relieving anxiety, depression, pain, and nausea. In conclusion, the link between cannabinoid compounds and oral cancer is complex, and further research is necessary to elucidate the potential risks or their protective impact on oral cancer.

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“…Approximately, 12% of head and neck cancer patients have been reported to be regular marijuana users. 18 19 Unlike tobacco, marijuana does not appear to confer an increased risk for head and neck cancer. 19 Evidence on the use of cannabinoids in the general cancer population indicate that there may be no advantage in pain, sleep, or overall quality of life.…”

Section: Alcohol Tobacco and Marijuana Usementioning

confidence: 99%

Psychological Survivorship in Head and Neck Cancer

2022

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Survivorship for head and neck cancer patients presents unique challenges related to the anatomic location of their disease. After treatment, patients often have functional impairments requiring additional care and support. In addition, patients may have psychological challenges managing the effect of the disease and treatment. Routine screening is recommended for the identification of psychological conditions. This article reviews the latest research on key psychological conditions associated with head and neck cancer. It discusses risk factors for the development of each condition and provides recommendations for the management of patients who may present with psychological concerns.

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Rate of Second Primary Head and Neck Cancer With Cannabis Use

Cited by 5 publications

References 13 publications

Attitudes Toward and Acceptability of Medical Marijuana Use Among Head and Neck Cancer Patients

Attitudes Toward and Acceptability of Medical Marijuana Use Among Head and Neck Cancer Patients

Role of Cannabinoids in Oral Cancer

Psychological Survivorship in Head and Neck Cancer

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