Rate of reaction of superoxide radical with chloride-containing species

Long, Charles A.; Bielski, Benon H. J.

doi:10.1021/j100442a023

Cited by 98 publications

(44 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the two-electron oxidation is so favourable that, in the case of CIO-, and BrO-, but not IO-, formation of singlet (Ia~) dioxygen is thermodynamically possible (Schemes 1-3), in agreement with experimental observations [14,15]. Reduction of hypochlorous acid by superoxide is possible followed by formation of the hydroxyl radical, and has been described [16][17][18]. The formation of hydroxyl radical and chloride from HOCI', the hydroxochlorate(1-) radical, is only slightly favourable [19].…”

Section: Discussionsupporting

confidence: 84%

Thermodynamic considerations on the formation of reactive species from hypochlorite, superoxide and nitrogen monoxide Could nitrosyl chloride be produced by neutrophils and macrophages?

Koppenol

1994

FEBS Letters

View full text Add to dashboard Cite

Hypohalous acids are poor one-electron oxidizing agents, such that reactions with hydrogen peroxide to yield radical species are not feasible. However, the oxidation of superoxide by hypohalous acids can be a source of hydroxyl or haline radicals. The oxidation of nitrogen monoxide by hypochlorous acid is favourable, but in all likelihood cannot compete with the diffusion-controlled reaction with superoxide to yield peroxynitrite. The reaction of the latter with hypochlorous acid may lead to nitrosyl chloride, a strongly oxidizing agent [E*'(NOC1/NO', CI) = 1.0 V] that is capable of nitrosylating organic compounds and thereby generating mutagens or promutagens.

show abstract

Section: Discussionsupporting

confidence: 84%

Thermodynamic considerations on the formation of reactive species from hypochlorite, superoxide and nitrogen monoxide Could nitrosyl chloride be produced by neutrophils and macrophages?

Koppenol

1994

FEBS Letters

View full text Add to dashboard Cite

show abstract

“…Unlike the reaction with H 2 O 2 , which must be metal-catalyzed to proceed at an appreciable rate, metal ion-independent one-electron reduction of HOCl proceeds at a rate that is sufficiently rapid to be important within the phagosome during stimulated respiration [68], conditions where both O 2 •− and HOCl are in relatively high concentration [3,50]. Indeed, evidence for MPO-dependent OH • formation under comparable conditions has been obtained in in vitro environments utilizing both neutrophils stimulated with soluble agonists and cell-free enzymatic systems [66].…”

Section: Synergism In Microbicidal Actionmentioning

confidence: 99%

What really happens in the neutrophil phagosome?

Hurst

2012

Free Radical Biology and Medicine

110

117

View full text Add to dashboard Cite

Current viewpoints concerning the bactericidal mechanisms of neutrophils are reviewed from a perspective that emphasizes challenges presented by the inability to duplicate ex vivo the intracellular milieu. Among the challenges considered are the influences of confinement upon substrate availability and reaction dynamics, direct and indirect synergistic interactions between individual toxins, and bacterial responses to stressors. Approaches to gauging relative contributions of various oxidative and nonoxidative toxins within neutrophils using bacteria and bacterial mimics as intrinsic probes are also discussed.

show abstract

“…Another mechanism by which HOCl could promote the formation of peroxyl radicals is the reaction with O 2 •Ϫ or Fe 2ϩ , generating • OH (55)(56)(57). The hydroxyl radical is considered to be one of the most powerful oxidants, with E°Ј • OH, H͞H 2 O ϭ 2.31 V (58) and, therefore, capable of oxidizing LAOOH to LAOO • .…”

Section: Detection Of Peroxyl Radical By Continuous-flow Eprmentioning

confidence: 99%

Linoleic acid hydroperoxide reacts with hypochlorous acid, generating peroxyl radical intermediates and singlet molecular oxygen

Miyamoto

Martinez²,

Rettori³

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

122

108

View full text Add to dashboard Cite

The reaction of hypochlorous acid (HOCl) with hydrogen peroxide is known to generate stoichiometric amounts of singlet molecular oxygen [O2 ( 1 ⌬g)]. This study shows that HOCl can also react with linoleic acid hydroperoxide (LAOOH), generating O2 ( 1 ⌬g) with a yield of 13 ؎ 2% at physiological pH. Characteristic light emission at 1,270 nm, corresponding to O2 ( 1 ⌬g) monomolecular decay, was observed when HOCl was reacted with LAOOH or with liposomes containing phosphatidylcholine hydroperoxides, but not with cumene hydroperoxide or tert-butyl hydroperoxide. The generation of O2 ( 1 ⌬g lipid hydroperoxides ͉ mass spectrometry ͉ myeloperoxidase ͉ near-infrared emission ͉ 18 O-labeled oxygen

show abstract

Rate of reaction of superoxide radical with chloride-containing species

Abstract: L O " ( b) Flgure 7. Possible approaches of DDQ toward the crown ether in the complex formation (see text).

Cited by 98 publications

References 1 publication

Thermodynamic considerations on the formation of reactive species from hypochlorite, superoxide and nitrogen monoxide Could nitrosyl chloride be produced by neutrophils and macrophages?

Thermodynamic considerations on the formation of reactive species from hypochlorite, superoxide and nitrogen monoxide Could nitrosyl chloride be produced by neutrophils and macrophages?

What really happens in the neutrophil phagosome?

Linoleic acid hydroperoxide reacts with hypochlorous acid, generating peroxyl radical intermediates and singlet molecular oxygen

Contact Info

Product

Resources

About