Rate of Progression of Aortic Stenosis in Patients With Cancer

Bravo‐Jaimes, Katia; Palaskas, Nicolas; Banchs, José; Abelhad, Nadia Isabel; Altaf, Alveena; Gouni, Sushanth; Song, Juhee; Hassan, Saamir; Iliescu, Cezar; Deswal, Anita; Yusuf, Salim

doi:10.3389/fcvm.2021.644264

Cited by 3 publications

(5 citation statements)

References 30 publications

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“…Moreover, chest radiation and cardiotoxic drugs (i.e., anthracyclines) have been noted to produce de novo AS via valve leaflet thickening, fibrosis, retraction, and calcification [ 15 ], but, at the present, the impact that they may have on AS progression has not been studied. Bravo-Jaimes et al have found that patients with mild or moderate AS and cancer are more likely to die before having AS progression, which is, in turn, associated with CAD and prevalent cyclophosphamide use [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Aortic Valve Stenosis and Cancer: Problems of Management

Santangelo,

Moscardelli,

Barbieri

et al. 2023

JCM

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Aortic valve stenosis and malignancy frequently coexist and share the same risk factors as atherosclerotic disease. Data reporting the prognosis of patients with severe aortic stenosis and cancer are limited. Tailoring the correct and optimal care for cancer patients with severe aortic stenosis is complex. Cancer patients may be further disadvantaged by aortic stenosis if it interferes with their treatment by increasing the risk associated with oncologic surgery and compounding the risks associated with cardiotoxicity and heart failure (HF). Surgical valve replacement, transcatheter valve implantation, balloon valvuloplasty, and medical therapy are possible treatments for aortic valve stenosis, but when malignancy is present, the choice between these options must take into account the stage of cancer and associated treatment, expected outcome, and comorbidities. Physical examination and Doppler echocardiography are critical in the diagnosis and evaluation of aortic stenosis. The current review considers the available data on the association between aortic stenosis and cancer and the therapeutic options.

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Section: Introductionmentioning

confidence: 99%

Aortic Valve Stenosis and Cancer: Problems of Management

Santangelo,

Moscardelli,

Barbieri

et al. 2023

JCM

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“…They deform into an elliptical shape following motion [6]. It is generally recognized that irregular intravascular growth causes stenosis to form at different points in the arterial system, reducing the lumen and obstructing blood flow [7]. High risk of death is experienced in a patient with cancer and aortic stenosis [7].…”

Section: Introductionmentioning

confidence: 99%

“…It is generally recognized that irregular intravascular growth causes stenosis to form at different points in the arterial system, reducing the lumen and obstructing blood flow [7]. High risk of death is experienced in a patient with cancer and aortic stenosis [7]. It has been suggested that the mechanical factors have significant role to determine where atherosclerosis occurs, low mean and oscillatory fluid wall shear stresses are also estimated to be responsible for the stenosis [8,9].…”

Section: Introductionmentioning

confidence: 99%

“…Bravo-Jaimes et al [7] have studied the patients having both cancer and aortic stenosis and concluded P. Gautam, C. Pokharel, G. Phaijoo, P. Kattel, J. Kafle, Effect of increasing stenosis over time on hemodynamics that such patients have high rate of progression in the increment of stenosis.…”

Section: Introductionmentioning

confidence: 99%

“…Above mentioned literature review shows that the blood flow in the stenosed part of an artery has high degree impact in hemodynamics and in cardiovascular disease. Naturally, the stenosis may increase over time and ultimately reach the condition of complete occlusion [7].…”

Section: Introductionmentioning

confidence: 99%

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Effect of increasing stenosis over time on hemodynamics

Gautam,

Pokharel,

Phaijoo

et al. 2023

BIOMATH

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A hard layer, that develops in the inner wall of an artery, makes the blood flow difficult and it can harm the cardiovascular system because of the abnormality in blood supply. The problem becomes worse when the layer gets thicker due to increased deposition over time. The effect of increasing stenosis on flow characteristics in an artery is studied by taking blood as a non-Newtonian fluid. To address the effect of increasing stenosis over time, a non-dimensional temporal term is included in the geometry of stenosis and is applied to derive the flow parameters like velocity profile, volumetric flow rate and pressure drop. The maximum and minimum shear stress ratio and pressure drop ratio are also calculated using the term. The results obtained are analyzed to show the effect of increasing stenosis over time on these flow parameters. Volumetric flow rate, pressure drop and its ratio, and shear stress ratio are compared with the ratio of the thickness of the stenosis and normal artery radius while analyzing the results. It is found that the volumetric flow rate decreases with time, pressure drop and its ratio increases with time, and the shear stress ratio decreases as the time elapses. The result shows that it is appropriate to include the temporal term to understand the effect of increasing stenosis over time on blood flow parameters. The aim of this article is to correct the drawback that evolves while supposing the symmetric shape of the stenosis.

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High-intensity exercise prescription guided by heart rate variability in breast cancer patients: a study protocol for a randomized controlled trial

Lavín-Pérez

Collado‐Mateo

González

et al. 2023

BMC Sports Sci Med Rehabil

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Background Breast cancer is a chronic disease with a large growth in its treatments, prognosis, improvements, side effects and rehabilitation therapies research. These advances have also highlighted the need to use physical exercise as a countermeasure to reduce the cardiotoxicity of pharmacological treatments, increase patients' strength and quality of life and improve body composition, physical condition and mental health. However, new investigations show the need for a closed exercise individualisation to produce higher physiological, physical and psychological benefits in remote exercise programs. To this end, the present study will use, in a novel way in this population, heart rate variability (HRV) as a measure for prescribing high-intensity training. Thus, the primary objective of this randomised clinical trial is to analyse the effects of a high-intensity exercise program daily guided by HRV, a preplanned moderate to high-intensity exercise intervention and a usual care group, in breast cancer patients after chemotherapy and radiotherapy treatments. Methods For this purpose, a 16-week intervention will be carried out with 90 breast cancer patients distributed in 3 groups (a control group, a moderate to high-intensity preplanned exercise group and a high-intensity exercise group guided by HRV). Both physical exercise interventions will be developed remotely and supervised including strength and cardiovascular exercises. Physiological variables, such as cardiotoxicity, biomarkers, lipid profile, glucose, heart rate and blood pressure; physical measures like cardiorespiratory capacity, strength, flexibility, agility, balance and body composition; and psychosocial variables, as health-related quality of life, fatigue, functionality, self-esteem, movement fear, physical exercise level, anxiety and depression will be measure before, after the intervention and 3 and 6 months follow up. Discussion Personalized high-intensity exercise could be a promising exercise intervention in contrast to moderate-intensity or usual care in breast cancer patients to reach higher clinical, physical and mental effects. In addition, the novelty of controlling HRV measures daily may reflect exercise effects and patients' adaptation in the preplanned exercise group and a new opportunity to adjust intensity. Moreover, findings may support the effectiveness and security of physical exercise remotely supervised, although with high-intensity exercise, to reach cardiotoxicity improvements and increase physical and psychosocial variables after breast cancer treatments. Trial registration ClinicalTrials.gov nº NCT05040867 (https://clinicaltrials.gov/ct2/show/record/NCT05040867).

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Rate of Progression of Aortic Stenosis in Patients With Cancer

Cited by 3 publications

References 30 publications

Aortic Valve Stenosis and Cancer: Problems of Management

Aortic Valve Stenosis and Cancer: Problems of Management

Effect of increasing stenosis over time on hemodynamics

High-intensity exercise prescription guided by heart rate variability in breast cancer patients: a study protocol for a randomized controlled trial

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