Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients

Schuster, Barbara; Ellmann, Anna; Mayo, Theresa; Auer, Judith; Haas, Matthias; Hecht, Markus; Fietkau, Rainer; Distel, Luitpold

doi:10.1186/s12877-018-0799-y

Cited by 22 publications

(31 citation statements)

References 43 publications

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“…It can be speculated that younger patients are more radiosensitive and therefore, have a stronger local tissue response to therapy, resulting in more severe treatment‐associated toxicity. Various mouse models have shown that radiosensitivity decreases with age; however, a more recent study, Schuster et al found that in cancer patients an age‐related increase of the individual radiosensitivity could not be demonstrated due to the strong interindividual variation . Further study is necessary to truly elucidate the role of age in predisposing head and neck cancer patients (and, more specifically, sinonasal cancer patients) in the occurrence of treatment‐related toxicity.…”

Section: Discussionmentioning

confidence: 99%

Treatment‐related morbidity in patients treated for sinonasal malignancy

Patel

Chitguppi

Vimawala

et al. 2020

Int Forum Allergy Rhinol

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Background: Sinonasal malignancies are a rare, heterogeneous group of tumors that o en present at an advanced stage and require multimodal therapy. The presence of high-grade toxicity and sinonasal complications a er treatment can negatively impact quality of life. In this study we aim to describe pos reatment morbidity in patients with sinonasal malignancy. Methods:A retrospective analysis of all patients treated for sinonasal malignancy was conducted from 2005 to 2018 at a tertiary referral institution. A total of 129 patients met the inclusion criteria. Primary outcomes were treatment details, pathology, pos reatment complications, and radiation toxicity. Fisher's exact test, chi-square test, and Student t test were used for statistical analysis.Results: Mean age was 58.4 (median, 61; range, 19-94) years. A er diagnosis, 24 patients had surgery alone, 46 had surgery with radiation alone, 47 had surgery with chemoradiation, and 14 received definitive chemoradiation. Overall, 10.4% (n = 12) of patients had postoperative complications, and 21.0% (n = 22) had high-grade (grade 3-5) radiation toxicity. A er radiation, 20% (n = 21) of patients had chronic sinusitis requiring functional endoscopic sinus surgery and 20% (n = 21) had symptomatic nasal obstruction requiring operative debridement. Conclusion:Sinonasal complications, including nasal obstruction and chronic sinusitis, occur frequently a er definitive treatment of sinonasal malignancy and should be addressed when considering quality of life in survivors. These complications occur more frequently in patients who undergo chemoradiation as opposed to surgery alone. C 2020 ARS-AAOA, LLC.

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Section: Discussionmentioning

confidence: 99%

Treatment‐related morbidity in patients treated for sinonasal malignancy

Patel

Chitguppi

Vimawala

et al. 2020

Int Forum Allergy Rhinol

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“…In parallel with this finding, there were no unusually severe clinical toxicities in the patient cohort. However, evidence from preclinical and clinical observations suggests that normal tissue toxicity is multifactorial, dynamic and progressive process [33][34][35]. Accordingly, in subgroups of patients with various grades of radiotoxicity, we found a correlation between Q-values and the toxicity grade for cough and dysphagia.…”

Section: Discussionmentioning

confidence: 62%

Monitoring DNA Damage and Repair in Peripheral Blood Mononuclear Cells of Lung Cancer Radiotherapy Patients

Lobachevsky

Bucknell

Mason

et al. 2020

Cancers

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Thoracic radiotherapy (RT) is required for the curative management of inoperable lung cancer, however, treatment delivery is limited by normal tissue toxicity. Prior studies suggest that using radiation-induced DNA damage response (DDR) in peripheral blood mononuclear cells (PBMC) has potential to predict RT-associated toxicities. We collected PBMC from 38 patients enrolled on a prospective clinical trial who received definitive fractionated RT for non-small cell lung cancer. DDR was measured by automated counting of nuclear γ-H2AX foci in immunofluorescence images. Analysis of samples collected before, during and after RT demonstrated the induction of DNA damage in PBMC collected shortly after RT commenced, however, this damage repaired later. Radiation dose to the tumour and lung contributed to the in vivo induction of γ-H2AX foci. Aliquots of PBMC collected before treatment were also irradiated ex vivo, and γ-H2AX kinetics were analyzed. A trend for increasing of fraction of irreparable DNA damage in patients with higher toxicity grades was revealed. Slow DNA repair in three patients was associated with a combined dysphagia/cough toxicity and was confirmed by elevated in vivo RT-generated irreparable DNA damage. These results warrant inclusion of an assessment of DDR in PBMC in a panel of predictive biomarkers that would identify patients at a higher risk of toxicity.

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“…A deterioration of the quality of life could be responsible for an increased response to the therapy, especially in normal tissue. The cause could be an increased sensitivity of the patients to radiation [39], which leads to increased side effects and at the same time to an enhanced effect on the tumour cells.…”

Section: Discussionmentioning

confidence: 99%

Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival

Jörling

Rutzner

Hecht

et al. 2020

BioMed Research International

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Objectives. Baseline health-related quality of life (HRQoL) scores predict survival, which has already been demonstrated in various studies. However, we were interested in whether changes in baseline scores during treatment are also significant predictors of survival. Methods and Materials. We analysed the data of 400 consecutive cancer patients receiving radiochemotherapy. Leading diagnoses were head and neck cancer (34.5%), rectal cancer (24.5%), and lung cancer (13%). HRQoL was studied at baseline, six weeks after therapy and after each completed year after the start of therapy until drop out of the study using the EORTC QLQ-C30 questionnaire. The change score was calculated as the baseline score subtracted from the score after therapy. Statistics included Kaplan-Meier estimates and Cox regression. Results. High global health status (p=0.005) and low pain scores (p=0.040) at baseline were related to favourable overall survival. Change scores of role functioning (p=0.027), global health status (p<0.018), and pain (p<0.001) were predictive of overall survival. Pain was the superior predictor of survival (p=0.001) among all variables and QoL scores studied by multivariate analysis. A deterioration in pain was associated with a 2.8 times higher chance of survival (HR 0.36). Conclusions. Deterioration of HRQoL baseline pain score by cancer treatment is a favourable and superior prognostic factor for survival.

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Rate of individuals with clearly increased radiosensitivity rise with age both in healthy individuals and in cancer patients

Cited by 22 publications

References 43 publications

Treatment‐related morbidity in patients treated for sinonasal malignancy

Treatment‐related morbidity in patients treated for sinonasal malignancy

Monitoring DNA Damage and Repair in Peripheral Blood Mononuclear Cells of Lung Cancer Radiotherapy Patients

Deterioration of Health-Related Quality of Life Scores under Treatment Predicts Longer Survival

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