Rate of change in body mass index at different ages during childhood and adult obesity risk

Zhang, Tao; Xi, Bo; Krousel‐Wood, Marie; Bazzano, Lydia A.; He, Jiang; Wei, Chen; Li, Shengxu

doi:10.1111/ijpo.12513

Cited by 26 publications

(25 citation statements)

References 42 publications

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“…[57,58]. Earlier BMI nadir and BMI accelerations from childhood to adolescence are risk factors for subsequent obesity, cardiometabolic disease, cardiovascular disease, ischemic stroke, and type 2 diabetes [7][8][9][10][11][12][13]. Given this, future studies could examine prenatal PFOA concentrations in relation to adolescent or adulthood cardiometabolic or cardiovascular risk factors or disease.…”

Section: Discussionmentioning

confidence: 99%

“…First, we determined whether the overall BMI trajectory varied according to PFAS tercile using the age × PFAS interaction term p value; we considered BMI trajectories to vary if this p value was <0.05. Then, we estimated five features of average BMI trajectories according to terciles of gestational PFAS concentrations that have been associated with increased risk of later life obesity and cardiometabolic disease [6][7][8][9][10][11][12][13]. These features included [1]: the age (years) of the infancy BMI zenith [2], the magnitude (kg/m 2 ) of infancy BMI zenith [3], the age (years) of early childhood BMI nadir [4], the magnitude (kg/m 2 ) of early childhood BMI nadir, and [5] the rate (kg/m 2 /year) of adolescent BMI change (age 8-12 years).…”

Section: Statistical Analysesmentioning

confidence: 99%

“…Obesity during childhood or adolescence increases the risk of atherosclerosis, cardiovascular disease, type 2 diabetes, hypertension, some cancers, and obesity in adulthood [2][3][4][5]. Early life adiposity patterns are strong risk factors for adolescent and adult obesity and cardiometabolic disease [6][7][8][9][10][11][12][13][14][15][16]. Later age and higher magnitude of infancy body mass index (BMI) zenith has been associated with excess adiposity and increased risk of obesity in adolescents and adults [8,14,15].…”

Section: Introductionmentioning

confidence: 99%

“…Epidemiological studies suggest that gestational PFAS exposure is associated with decreased fetal growth [32,33], alterations in infant or childhood growth [34,35], and increased adiposity during infancy, childhood, and adulthood [35][36][37][38][39][40]. However, we are unaware of studies examining whether gestational PFAS exposure is associated with childhood adiposity patterns related to later life obesity or cardiometabolic disease, namely higher infancy BMI zenith, earlier BMI nadir, or accelerations in BMI accrual during childhood and adolescence [7][8][9][10][11][12][13]. Thus, we used a prospective cohort study to investigate whether maternal serum concentrations of four PFAS were associated with features of BMI patterns from age 4 weeks to 12 years in 345 children from Cincinnati, Ohio.…”

Section: Introductionmentioning

confidence: 99%

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Gestational perfluoroalkyl substance exposure and body mass index trajectories over the first 12 years of life

et al. 2020

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Background/objectives Gestational exposure to perfluoroalkyl substances (PFAS), a ubiquitous class of persistent endocrine disrupting chemicals, is associated with increased risk of obesity and cardiometabolic disease. However, it is unclear if gestational PFAS exposure is associated with adiposity trajectories related to adult obesity and cardiometabolic health. Subjects/methods We measured perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononaoic acid, and perfluorohexanesulfonic acid (PFHxS) concentrations in maternal serum collected between 16 weeks gestation and delivery in a cohort of 345 mother-child pairs in Cincinnati, OH (enrolled 2003-06). From age 4 weeks to 12 years, we measured weight and length or height up to eight times and calculated child body mass index (BMI) (1865 repeated measures). Using covariate-adjusted linear mixed models and splines to account for repeated BMI measures and nonlinear BMI patterns, respectively, we estimated the age/magnitude of infancy BMI zenith (~1 year) and childhood BMI nadir (~5 years), BMI accrual from 8 to 12 years, and BMI at age 12 years by PFAS terciles. Results BMI trajectories varied by PFOA concentrations (age × PFOA interaction p value = 0.03). Children born to women with higher PFOA concentrations had lower infancy and early childhood BMI, earlier BMI nadir, accelerating BMI gains in mid-childhood and adolescence, and higher BMI at age 12 years. Some of these associations were non-monotonic. PFOS and PFHxS were not associated with alterations in BMI trajectories, but were monotonically associated with lower BMI across infancy, childhood, and adolescence. Compared to children in the first PFOS tercile, those in the second (β: −0.83; 95% confidence interval (CI): −2.11, 0.51 kg/m 2), and third (β: −1.41; 95% CI: −2.65, −0.14 kg/m 2) had lower BMI at age 12 years. Conclusions These results suggest that gestational PFOA exposure may be associated with BMI trajectories related to adult obesity and cardiometabolic disease, while PFOS and PFHxS exposure is associated with lower BMI in the first 12 years of life.

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Section: Discussionmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Gestational perfluoroalkyl substance exposure and body mass index trajectories over the first 12 years of life

et al. 2020

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“…We computed the baseline characteristics (mean, standard deviation) for each gender. Differences in means between participants of different gender were assessed using Studentʼs t test or Wilcoxon rank sum test as appropriate. Differences in means between different age groups were assessed using Kruskal‐Wallis H test.…”

Section: Methodsmentioning

confidence: 99%

Dynamic Change of Lumbar Structure and Associated Factors: A Retrospective Study

Wei

Zhu

Zhao

et al. 2019

Orthopaedic Surgery

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Objective: To determine whether lumbar anatomy parameters are in dynamic change and related factors.Methods: This is a retrospective study. Participants who did lumbar computed tomography (CT) scanning in Shandong University Qilu Hospital from October 2017 to March 2019 were selected. The 476 participants were randomly selected as male or female, with the age ranging from 17 to 87 years (mean, 55.19; standard deviation, 14.28 years). All the measurements were taken based on the CT scanning image and the measurement of lumbar morphology was conducted using picture archiving and communication systems (PACS). The angle between the horizontal alignment and pedicle center on median sagittal view, the angle between upper endplate and lower endplate on median sagittal view as well as transverse section angle (TSA) using Magerl point in the axial view was determined by reconstructive CT analysis.Results: In the overall participants, the angle between the horizontal alignment and pedicle center on median sagittal view of lumbar one to three was significantly decreased with aging, from 3.90 AE 2.81 to −4.18 AE 6.86 (P = 0.002), 5.60 AE 2.89 to −4.14 AE 5.90 (P = 0.030), and 4.75 AE 2.95 to −2.87 AE 4.68 (P < 0.001), respectively. Additionally, the angle between the horizontal alignment and pedicle center on median sagittal view in male participants of lumbar two was dramatically decreased, from 4.83 AE 2.79 to −4.45 AE 5.97 (P = 0.30). And that of lumbar three in female participants was significantly decreased, from 4.56 AE 2.52 to −2.88 AE 5.03 (P = 0.029). Furthermore, of the overall participants, the angle between upper endplate and lower endplate on median sagittal view of lumbar one to four was associated with aging (P < 0.001, P < 0.001, P = 0.015, P < 0.001, respectively). The angle of lumbar one, two and four in male participants and lumbar one to four in female participants were all significantly related to aging (all P < 0.05). Moreover, in the participants overall, the TSA of lumbar one to three was significantly associated with aging (P = 0.015, P = 0.006 and P = 0.007, respectively). In addition, this angle in lumbar one to lumbar four in male participants were all negatively associated with aging (P = 0.017, P = 0.001, P = 0.005 and P = 0.036, respectively). Conclusion:Lumbar anatomy parameters are in dynamic change in an age and gender dependent manner. During spine surgery in elderly patients, more attention should be paid to these anatomic changes.

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Evolution, Trajectories, and Prognosis of Pediatric Obesity

Moya

2023

Pediatric Overweight and Obesity

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Rate of change in body mass index at different ages during childhood and adult obesity risk

Cited by 26 publications

References 42 publications

Gestational perfluoroalkyl substance exposure and body mass index trajectories over the first 12 years of life

Gestational perfluoroalkyl substance exposure and body mass index trajectories over the first 12 years of life

Dynamic Change of Lumbar Structure and Associated Factors: A Retrospective Study

Evolution, Trajectories, and Prognosis of Pediatric Obesity

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