Rate of Apposition of Dentine in Upper Incisors in Normal and Hormone-Treated Rats with a Tentative Comparison of the Apposition of Dentine and Lamellar Bone

Ahlgren, Sven-Arne

doi:10.3109/ort.1968.39.suppl-116.01

Cited by 5 publications

(2 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cortisol concentrations from modern dentine suggest that detectable quantities of cortisol can be present within the tissue, seemingly refuting hypotheses that cortisol is too rapidly metabolized to be incorporated into dental tissues (Nejad et al, 2016). Further, there is evidence that enamel and dentine can be influenced by hormones and exogenous chemicals (Ahlgren, 1968; Houari et al, 2016). Ameloblasts (enamel forming cells) have been found to contain glucocorticoid hormonal receptors depending on their developmental stage (Houari et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…It has even been suggested that amelogenesis is regulated by endogenous steroid hormones, affecting the quality, hardness and mineralization of the enamel (Houari et al, 2016; Pawlicki, Knychalska‐Karwin, Stankiewicz, Jakób‐Dolezal, & Karwan, 1992). Hydrocortisone (a synthetic variant) has been found to retard dentine formation under experimental conditions (Ahlgren, 1968). Studies of drug concentrations within dental hard tissues (Cattaneo, Gigli, Lodi, & Grandi, 2003) have been criticized for not adequately removing pulp tissues before processing, potentially confounding reported results (Rubin, 2018; Spinner et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Quade

Chazot

Gowland

2020

American J Phys Anthropol

View full text Add to dashboard Cite

Objectives: Cortisol is a glucocorticoid hormone produced through activation of the hypothalamic pituitary adrenal axis. It is known as the "stress hormone" for its primary role in the body's stress response and has been the focus of much modern clinical research. Within archaeology, only a few studies have analyzed cortisol in human remains and these have been restricted to hair (Webb et al., 2010; Webb, White, van Uum, & Longstaffe, 2015a; Webb, White, van Uum, & Longstaffe, 2015b). This study examines the utility of dentine and enamel, which survive well archaeologically, as possible reservoirs for detectable levels of cortisol. Materials and methods: Then, 69 teeth from 65 individuals from five Roman and Post-Roman sites in France were tested via competitive enzyme-linked immunosorbent assay (ELISA) to assess and quantify the cortisol concentrations present within tooth dentine and enamel. Results: In both tooth dentine and enamel, detectable concentrations of cortisol were identified in multiple teeth. However, concentrations were low and not all teeth yielded results that were measurable through cortisol ELISA. Differences in cortisol values between dentine and enamel could suggest different uptake mechanisms or timing. Discussion: These results suggest that cortisol is incorporated within tooth structures and merits further investigation in both modern and archaeological contexts. Analysis of the results through liquid chromatographic-mass spectrometry would verify current results and might yield values that could be better integrated with published cortisol studies. Future studies of cortisol in tooth structures would greatly expand the research potential of cortisol in the past and could have implications for studies of human stress across deep time.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Quade

Chazot

Gowland

2020

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

Effect of hypophysectomy on dentin production in maxillary incisors in the rat

Hansson

Stenström

Thorngren

1978

European J Oral Sciences

View full text Add to dashboard Cite

abstract— The effect of hypophysectomy on the dentin production and on the longitudinal growth of the maxillary incisors of female rats 60–105 d of age was determined In‐ the tetracycltne technique. In normal rats, the highest rate of dentin apposition amounted to about 23μm per clay in the middle part of the tooth with lower values in apical and incisal directions. Because of incisal attrition, the tooth was exchanged in about 55 d, corresponding to a longitudinal growth rate of'about 400μm per day. After hypophysectomy, the rate of dentin production was reduced to about 60%, with a considerable variation depending on the position of the odontoblasts along the tooth. The longitudinal growth rate was reduced to about 50% of normal. As the length of the tooth was the same within the period studied, this resulted in a slower transfer of the odontoblasts along the tooth and a time delay of about 55 d before they reached the incisal part of the tooth. The total dentin production of the odontoblasts in the hypophysectomized animals was the same as in normals. Compared with the effect of hypophysectomy on the rate of longitudinal bone growth and cortical bone remodeling, the effect on the dentin production and longitudinal growth of the incisors is less pronounced, indicating differences in sensitivity to hormones between the different cell systems.

show abstract

Effect of pituitary hormones on dentin production in maxillary incisors in the rat

Hansson

Stenström

Thorngren

1978

European J Oral Sciences

View full text Add to dashboard Cite

abstract— The effect of pituitary hormones on dentin production and longitudinal growth of the maxillary incisors in normal and hypophysectomized rats was investigated. Bovine growth hormone was found to increase the dentin production slightly in normal rats and significantly in hypophysectomized rats. Other pituitary hormones showed no effects on dentin apposition in the doses and periods tested. The effects of the pituitary hormones on the longitudinal growth of the tooth were small or insignificant. The effects of growth hormone on the dentin apposition and the longitudinal growth of the tooth after hypophysectomy were smaller than the effects on longitudinal bone growth and cortical hone remodeling, indicating different sensitivity to hormones between different mineralized tissues.

show abstract

Rate of Apposition of Dentine in Upper Incisors in Normal and Hormone-Treated Rats with a Tentative Comparison of the Apposition of Dentine and Lamellar Bone

Cited by 5 publications

References 87 publications

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Desperately seeking stress: A pilot study of cortisol in archaeological tooth structures

Effect of hypophysectomy on dentin production in maxillary incisors in the rat

Effect of pituitary hormones on dentin production in maxillary incisors in the rat

Contact Info

Product

Resources

About