Abstract:The bacterial adhesin FimH is a model for the study of protein allostery
because its structure has been resolved in multiple configurations,
including the active and the inactive state. FimH consists of a pilin
domain (PD) that anchors it to the rest of the fimbria and an
allosterically regulated lectin domain (LD) that binds mannose on the
surface of infected cells. Under normal conditions, the two domains are
docked to each other and LD binds mannose weakly. However, in the
presence of tensile force generate… Show more
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