Rate and Predictors of Bacteremia in Afebrile Community-Acquired Pneumonia

Forstner, Christina; Patchev, Vladimir K.; Witzenrath, Martin; Welte, Tobias; Burgmann, Heinz; Dreher, Michael; Cornelissen, Christian; Knüppel, W.; Stolz, Daiana; Suttorp, N; Creutz, Petra; Mikołajewska, Agata; Bauer, T.; Krieger, D.; Pankow, Wulf; Thiemig, Dorina; Hauptmeier, B.; Ewig, Santiago; Wehde, DD; Prediger, M.; Schmager, S.; Kolditz, Martin; Schulte-Hubbert, B.; Langner, Shannon; Albrich, Werner C.; Freise, J.; Barten, G; Toro, O. Arenas; Nawrocki, M.; Naim, John O.; Witte, M.A. de; Kröner, Waldemar; Illig, Thomas; Klopp, Norman; Kreuter, Matthew W.; Herth, Felix; Hummler, Simone; Ravn, Pernille; Vestergaard-Jensen, A.; Baunbæk-Knudsen, Gertrud; Pletz, Mathias W.; Kroegel, Claus; Frosinski, J.; Winning, Johannes; Schleenvoigt, Benjamin T.; Dalhoff, K; Rupp, Jan; Hörster, R.; Drömann, Daniel; Rohde, Gernot; Drijkoningen, Jesse; Braeken, Dionne C.W.; Buschmann, H.; Schaberg, T.; Hering, Ilona; Panning, Marcus; Wallner, M.

doi:10.1016/j.chest.2019.10.006

Cited by 20 publications

(14 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, testing for Mycoplasma pneumoniae is missing in this analysis as it was only performed in 2011–2012 with a frequency of 12.3% [ 15 ]. Furthermore, a substantial proportion of patients were pre-treated with antibiotics, thus decreasing the diagnostic yield [ 16 ].…”

Section: Brief Reportmentioning

confidence: 99%

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

et al. 2021

Self Cite

View full text Add to dashboard Cite

To determine the most relevant pathogens for CAP in Germany, patients with radiologically confirmed pulmonary infiltrates and at least one clinical sign of lung infection were prospectively recruited within the CAPNETZ cohort from 2004 until 2016. In 990 out of 4.672 patients (21%) receiving complete diagnostics the most prominent change of pathogens was a decrease of S. pneumoniae (58% in 2004 to 37.5% in 2016; p ≤ 0.001, ρ = − 0.148) and an increase of H. influenzae (12.2% to 20.8%; p = 0.001, ρ = 0.104).

show abstract

Section: Brief Reportmentioning

confidence: 99%

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…The generation of cytokine storm can lead to acute kidney injury, which is a nonnegligible cause of death. In addition, elevated level of BUN was observed to be the independent predictor of bacteremia in community-acquired pneumonia [27]. Combined with the increased level of leukocyte and procalcitonin in non-survivors of elderly patients with COVID-19, particular attention should be paid on the abnormal level of BUN.…”

Section: Discussionmentioning

confidence: 99%

 Risk factors for mortality in patients over 70 years old with COVID-19

Zhu¹,

Yuan²,

Shao³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Elderly patients with COVID-19 were shown to have a high case-fatality rate. We aimed to explore the risk factors associated with death in patients over 70 years old (yo).Methods: In this retrospective study, we enrolled patients over 70 yo with COVID-19 between January 20 and February 15, 2020. Epidemiological, demographic, and clinical data were collected. Univariate and multivariate Cox regression methods were used to explore the risk factors.Results: A total of 147 patients were enrolled. The case-fatality rate was 28.6%. Multivariate Cox proportional hazard regression showed that clinical subtypes including the severe type (HR = 2.983, 95% CI: 1.231–7.226, P = 0.016) and the critical type (HR = 3.267, 95%CI: 1.009–10.576, P = 0.048) were associated with increasing risk of death when compared with the general type. Blood urea nitrogen greater than 9.5 mmol/L (HR = 2.805, 95% CI: 1.141–6.892, P = 0.025) on admission was an independent risk factor for death among laboratory findings.Conclusion: The patients over 70 yo with COVID-19 had a high case-fatality rate. The risk factors including clinical subtypes and blood urea nitrogen greater than 9.5 mmol/L could help physicians to identify elderly patients with poor clinical outcomes at an early stage.

show abstract

“…The generation of cytokine storm can lead to acute kidney injury, which is a nonnegligible cause of death. In addition, elevated level of BUN was observed to be the independent predictor of bacteremia in community-acquired pneumonia [ 26 ]. Combined with the increased level of leukocyte and procalcitonin in non-survivors of elderly patients with COVID-19, particular attention should be paid on the abnormal level of BUN.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for mortality in patients over 70 years old with COVID-19 in Wuhan at the early break: retrospective case series

et al. 2021

View full text Add to dashboard Cite

Background Elderly patients with COVID-19 were shown to have a high case-fatality rate. We aimed to explore the risk factors associated with death in patients over 70 years old (yr). Methods In this retrospective study, we enrolled consecutively hospitalized patients over 70 yr with COVID-19 between January 20 and February 15, 2020 in Renmin Hospital of Wuhan University. Epidemiological, demographic, and clinical data were collected. Clinical subtypes, including mild, moderate, severe, and critical types, were used to evaluate the severity of disease. Patients were classified into two groups: survivor and non-survivor groups. Clinical data were compared between the two groups. Univariable and multivariable Cox regression methods were used to explore the risk factors. Results A total of 147 patients were enrolled. The case-fatality rate was 28.6%. Multivariable Cox proportional hazard regression showed that clinical subtypes, including the severe type (HR = 2.983, 95% CI: 1.231–7.226, P = 0.016) and the critical type (HR = 3.267, 95%CI: 1.009–10.576, P = 0.048), were associated with increasing risk of death when compared with the general type. Blood urea nitrogen greater than 9.5 mmol/L (HR = 2.805, 95% CI: 1.141–6.892, P = 0.025) on admission was an independent risk factor for death among laboratory findings. Conclusion The patients over 70 yr with COVID-19 had a high case-fatality rate. The risk factors, including clinical subtypes and blood urea nitrogen greater than 9.5 mmol/L, could help physicians to identify elderly patients with poor clinical outcomes at an early stage.

show abstract

Rate and Predictors of Bacteremia in Afebrile Community-Acquired Pneumonia

Cited by 20 publications

References 27 publications

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

Risk factors for mortality in patients over 70 years old with COVID-19

Risk factors for mortality in patients over 70 years old with COVID-19 in Wuhan at the early break: retrospective case series

Contact Info

Product

Resources

About

Rate and Predictors of Bacteremia in Afebrile Community-Acquired Pneumonia

Cited by 20 publications

References 27 publications

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

Shift in bacterial etiology from the CAPNETZ cohort in patients with community-acquired pneumonia: data over more than a decade

&nbsp;Risk factors for mortality in patients over 70 years old with COVID-19

Risk factors for mortality in patients over 70 years old with COVID-19 in Wuhan at the early break: retrospective case series

Contact Info

Product

Resources

About

Risk factors for mortality in patients over 70 years old with COVID-19