Rate And Magnitude Of Age Pigment Accumulation In The Human Myocardium

Extrinsic and intrinsic blood supply and histomorphological changes associated with age in the cerebral arteries and brain nuclei in dog (Canis familiaris) and pig (Sus scrofa domestica)

“…The latter studies showed that the pigment accumulation was definitely present in the above nuclei both in the dog and pig. Strehler, et al (1959) intraneuronal pigment was taken into consideration similar views were exhibited by Andrew (1956), Sulkin (1958) andFew (1966).…”

“…Sulkin and Kuntz (1952) and Sulkin (1955) observed the varying degree and frequency of pigment distribution in dif ferent nuclei of the nervous system in man and dog. Strehler, et al (1959) studied the quantitative increase of the lipofuscin pigment in the cardiac muscle and found an increasing trend with age. Wilcox (1959) regarded the presence of lipofuscin in the cranial nerve nuclei of mice as the only sig nificant age change.…”

“…Chu (195^) regarded the pigment as a product of activity rather than aging. Strehler, _et (1959) studied the lipofuscin accumula tion in the myocardium and stated that the pigment may inter fere with efficient functioning of the heart muscle. The pig ment particles may act as a binding agent between contractive elements.…”

“…Bondareff (1957Bondareff ( . 1959, Strehler, _et (1959), Strehler (1962), Whiteford (1964), Getty (1966), Few (1966) and Few and Getty (I967) concluded that in the postmitotic cells, the most consistent morphologic observa tions was the accumulation of the lipofuscin pigment with in creasing age.…”

Age changes in the canine pancreas: histomorphological, electron microscopic, and biochemical study

“…Several investigators have related an increase in lipofuscin concentration to advancing age (Bohmig, 1935;Jayne, 1950;Strehler et al, 1959). The occurrence of lipofuscin has been reported in a variety of organs, such as the canine and porcine brain (Whiteford and Getty, 1966) and rodent brain (Reichel ejb ^ 1968), the adrenal, ovary, testes, heart, and kidney of the rat (Reichel,196 8), the canine heart (Munnell and Getty,196 8c), the spinal cord and ventral horn (Sulkin, 1955;Few and Getty, 1967), spinal ganglia (Bondareff, 1957), and the liver (Haraszti et , 1967).…”