Rate and amount of visual loss in 102 patients with Open-Angle glaucoma followed up for at least 15 years

Eid, Tarek; Spaeth, George L.; Bitterman, Anya; Steinmann, William C.

doi:10.1016/s0161-6420(03)00076-9

Cited by 40 publications

(32 citation statements)

References 20 publications

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“…The systems of disc and field grading used in this study are believed to be more appropriate, since no stereo photography of the optic nerve head was available and, as done in other studies (13,14) we had to consider a categorical manner to analyze different visual field perimeters during the follow-up period.…”

Section: Discussionmentioning

confidence: 99%

“…Blindness was defined as visual acuity worse than 20/200, and/ or continuous constriction of the visual field to less than 20 o in all four quadrants with a size III4e Goldmann stimulus or the equivalent on automated perimetry, allowing a higher threshold level on one point in one quadrant, attributable to glaucoma (14) in the worst eye (unilateral) or in both eyes.…”

Section: Methodsmentioning

confidence: 99%

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Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years

Paula¹,

Furtado²,

Santos³

et al. 2012

Arq. Bras. Oftalmol.

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Purpose: To determine the proportion of blindness and investigate the relationships between risk factors based on clinical characteristics and development of blindness in patients with primary open-angle glaucoma (POAG) treated for at least 15 years. Methods: A retrospective observational chart review was performed with 403 pa tients referred to a tertiary level hospital, each with a diagnosis of primary openangle glaucoma, treated for at least 15 years. Blindness attributable to glaucoma was defined based on visual acuity and/or visual field tests. Variables considered to be possible risk factors for blindness were evaluated using odds ratio (OR), confidence interval (95% CI), and univariate and multivariate analyses. Results: Thirty-one patients became blind [13/53 (24.5%) -unilaterally and 18/53 (34%) -bilaterally] during the follow-up period of treatment (19.5 ± 4.6 years, range 15-31 years). Multivariate statistics with regression analysis revealed that persis tency on initial therapy ≤6 months was significantly associated with blindness, both unilateral (OR: 8.4; 95% CI: 1.3-56.4) and bilateral (OR: 7.2; 95% CI: 1.3-39.6). Other potential factors such as race, age, gender or number of medications were not associated with blindness. Conclusion:Blindness from primary open-angle glaucoma was not uncommon in this population of treated patients after the long follow-up period proposed. Persistence rates with the first therapy, as measured by a medical decision to change, were low. Persistence ≤6 months was statistically associated with the development of unilateral and bilateral blindness from glaucoma.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years

Paula¹,

Furtado²,

Santos³

et al. 2012

Arq. Bras. Oftalmol.

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“…Two additional randomised trials 255,262 and seven cohort studies 259,[263][264][265][266][267][268] met the inclusion criteria and were included. From the results presented in Table 30, it was possible to estimate the yearly probability of progressing from the various OAG stages.…”

Section: Approachmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Burr¹,

Mowatt²,

Hernández³

et al. 2007

Health Technol Assess

328

380

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“…In the Advanced Glaucoma Intervention Study (AGIS), some authors (2004) showed a 30% mean worsening of the visual field after two years (21) . A few long-term studies have shown rates of worsening up to 81.4% after 20-years follow-up (15) . Over a mean follow-up period of 40 months, we observed that approximately 21% of patients worsened to another glaucoma category.…”

Section: Discussionmentioning

confidence: 99%

“…(15) . Whenever a discrepancy was found between the optic disc cup and MD, the optic disc cup was considered for staging and analysis.…”

Section: Methodsmentioning

confidence: 99%

Medical decision, persistence of initial treatment, and glaucoma progression in a Brazilian reference hospital

Paula¹,

Filho²,

Cecchetti³

et al. 2010

Arq. Bras. Oftalmol.

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Rate and amount of visual loss in 102 patients with Open-Angle glaucoma followed up for at least 15 years

Cited by 40 publications

References 20 publications

Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years

Risk factors for blindness in patients with open-angle glaucoma followed-up for at least 15 years

The clinical effectiveness and cost-effectiveness of screening for open angle glaucoma: a systematic review and economic evaluation

Medical decision, persistence of initial treatment, and glaucoma progression in a Brazilian reference hospital

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