Rat-transmitted hantavirus disease in Sarajevo

Clément, Jan; Kenna, Paula Mc; Avšič–Županc, Tatjana; Skinner, Cynthia Ruth

doi:10.1016/s0140-6736(94)91319-6

Cited by 18 publications

(6 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sporadic cases of human disease caused by SEOV have been documented in several countries outside of Korea (Clement et al 1994, Clement et al 1997, Chow et al 2005, and human disease has been identified in Salvador (A.I. Ko, unpublished data) and other Brazilian cities (LeDuc et al 1985, Iversson et al 1992, Katz et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Infections byLeptospira interrogans, Seoul Virus, andBartonellaspp. Among Norway Rats (Rattus norvegicus) from the Urban Slum Environment in Brazil

Costa

Porter

Rodrigues

et al. 2014

Vector-Borne and Zoonotic Diseases

127

123

View full text Add to dashboard Cite

Norway rats (Rattus norvegicus) are reservoir hosts for zoonotic pathogens that cause significant morbidity and mortality in humans. Studies evaluating the prevalence of zoonotic pathogens in tropical Norway rat populations are rare, and data on co-infection with multiple pathogens are nonexistent. Herein, we describe the prevalence of leptospiral carriage, Seoul virus (SEOV), and Bartonella spp. infection independently, in addition to the rates of co-infection among urban, slum-dwelling Norway rats in Salvador, Brazil, trapped during the rainy season from June to August of 2010. These data were complemented with previously unpublished Leptospira and SEOV prevalence information collected in 1998. Immunofluorescence staining of kidney impressions was used to identify Leptospira interrogans in 2010, whereas isolation was used in 1998, and western blotting was used to detect SEOV antibodies in 2010, whereas enzyme-linked immunosorbent assay (ELISA) was used in 1998: in 2010, Bartonella spp. were isolated from a subsample of rats. The most common pathogen in both years was Leptospira spp. (83%, n = 142 in 1998, 63%, n = 84 in 2010). SEOV was detected in 18% of individuals in both 1998 and 2010 (n = 78 in 1998; n = 73 in 2010), and two species of Bartonella were isolated from 5 of 26 rats (19%) tested in 2010. The prevalence of all agents increased significantly with rat mass/age. Acquisition of Leptospira spp. occurred at a younger mass/age than SEOV and Bartonella spp. infection, suggesting differences in the transmission dynamics of these pathogens. These data indicate that Norway rats in Salvador serve as reservoir hosts for all three of these zoonotic pathogens and that the high prevalence of leptospiral carriage in Salvador rats poses a high degree of risk to human health.

show abstract

Section: Discussionmentioning

confidence: 99%

Infections byLeptospira interrogans, Seoul Virus, andBartonellaspp. Among Norway Rats (Rattus norvegicus) from the Urban Slum Environment in Brazil

Costa

Porter

Rodrigues

et al. 2014

Vector-Borne and Zoonotic Diseases

127

123

View full text Add to dashboard Cite

show abstract

“…The SEOV has a worldwide distribution and it has been found in rats of the species Rattus rattus and Rattus norvegicus from around the world (Clement et al 1994, 1997, McCaughey and Hart 2000, Heyman et al 2004, 2009, Lokugamage et al 2004. For this reason, it could be cause of human diseases worldwide (McCaughey and Hart 2000, Lledó et al 2004, Chow et al 2005.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, it has been detected in rats from Asia, America, and Europe (McCaughey and Hart 2000, Heyman et al 2004, 2009, Lokugamage et al 2004. Thus, SEOV could be a cause of human disease worldwide (Clement et al 1994, 1997, McCaughey and Hart 2000, Lledó et al 2004, Chow et al 2005.…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiological Survey of Hantavirus Infection in Healthy People in Vallès Occidental, Barcelona

Sanfeliú

Nogueras

Gegúndez

et al. 2011

Vector-Borne and Zoonotic Diseases

View full text Add to dashboard Cite

show abstract

“…Croatia borders Slovenia to the northwest and has an extended border to Bosnia and Herzegovina, one of the greatest HFRS endemic areas in Europe [Markotic Â et al, 1996]. Both Puumala (PUUV) and Dobrava (DOBV) viruses were found to cause HFRS in Slovenia and Bosnia and Herzegovina [Avs Ïic Ï-Z Ï upanc et al, 1992;Lundkvist et al, 1997], with the addition of Seoul virus in Bosnia and Herzegovina [Clement et al, 1994;Markotic Â et al, 1995].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of puumala and Dobrava infections in Croatia*

Markotić

St²,

Kuzman

et al. 2002

Journal of Medical Virology

View full text Add to dashboard Cite

In this study, two different hantaviruses, Puumala virus (PUUV) and Dobrava virus (DOBV), were demonstrated for the first time to coexist and cause hemorrhagic fever with renal syndrome (HFRS) in Croatia. Phylogenetic analysis showed some differences among the nucleotide sequences of PUUV originating from Dinara mountain, which was more closely related to Austrian PUUV than other Croatian PUUV from Mala Kapela mountain. More consistency was found among the Croatian DOBV. HFRS was verified in 85 of 201 suspected cases recorded in 1995 during the largest HFRS outbreak in Croatia. Most of these cases were soldiers. With the exception of the coastal region and islands, all of Croatia was found to be an area endemic for HFRS. A statistically significantly higher proportion of DOBV-infected patients had acute renal failure, visual disturbance, severe thrombocytopenia, and elevated levels of nonsegmented leukocytes, creatine, and total bilirubin. The prevalence of gastrointestinal and electrocardiography disorders also was greater in DOBV-infected patients. Interestingly, significantly more PUUV-infected patients had elevated systolic blood pressure on admission to the hospital. Further prospective studies are necessary to shed more light on differences in HFRS severity associated with PUU and DOB viruses.

show abstract

Rat-transmitted hantavirus disease in Sarajevo

Cited by 18 publications

References 4 publications

Infections byLeptospira interrogans, Seoul Virus, andBartonellaspp. Among Norway Rats (Rattus norvegicus) from the Urban Slum Environment in Brazil

Infections byLeptospira interrogans, Seoul Virus, andBartonellaspp. Among Norway Rats (Rattus norvegicus) from the Urban Slum Environment in Brazil

Seroepidemiological Survey of Hantavirus Infection in Healthy People in Vallès Occidental, Barcelona

Characteristics of puumala and Dobrava infections in Croatia*

Contact Info

Product

Resources

About