Rat‐to‐mouse small bowel xenotransplantation: A novel model for studying acute vascular and hyperacute xenograft rejection and xenogenic cell migration
Abstract:The present study was undertaken to establish a rat-to-mouse vascularized small bowel xenotransplantation model to study acute vascular and hyperacute xenograft rejection, and xenogenic cell migration. Lewis rat small bowel grafts were transplanted heterotopically to group 1, Balb/c mice, and group 2, Balb/c mice pre-sensitized with a donor spleen cell injection. The grafts were examined by serial pathology and flow cytometry. In group 1, acute vascular rejection was present by the 5th post-operative day (POD)… Show more
“…However, there were two reviews of some of the factors involved in the process [51,52]. There were also two new models proposed to study this type of rejection: one involving lung transplants from pigs to goats [53] and the other involving small bowel transplantation from rats to mice [54].…”
“…However, there were two reviews of some of the factors involved in the process [51,52]. There were also two new models proposed to study this type of rejection: one involving lung transplants from pigs to goats [53] and the other involving small bowel transplantation from rats to mice [54].…”
“…Small bowel transplantation has been suggested as a possible model to study delayed xenograft rejection/acute vascular rejection (DXR/AVR) in concordant species combinations because it allows frequent biopsies to monitor the process [17]. Chen et al.…”
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