Rat strain differences in peritoneal immune cell response to selected gut microbiota: A crossroad between tolerance and autoimmunity?

Blagojević, Veljko; Kovačević-Jovanović, Vesna; Ćuruvija, Ivana; Petrović, Raisa; Vujnović, Ivana; Vujić, Vesna; Stanojević, Stanislava

doi:10.1016/j.lfs.2018.02.011

Cited by 6 publications

(7 citation statements)

References 61 publications

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“…greater proportion of CCR7-expressing CD163 + macrophages in DA than in AO rats following PBS treatment and on d7 and, more importantly, the greater proportion of CCR7-expressing than CCR7-negative CD163 + macrophages within CD163 + macrophage pool in DA rats, additionally supports more intense priming of DA rat cells by local peritoneal millieu [6], both under basal conditions and during resolution following LB injection. The presence of CCR7 molecule on all CD163 + macrophages on d2 following LB in rats of both rat strains creates an inflammatory milieu that is a prerequisite for later profibrotic environment and development of fibrosis during the chronic phase of inflammation [55].…”

Section: Discussionmentioning

confidence: 73%

“…Inflammatory CCR2 hi monocytes that are selectively recruited to the peritoneum during peritonitis also express CCR7 [66]. Hence, it would be interesting to explore if greater proportion of CCR7 + cells and higher expression level of CCR7 molecules in cells of DA rats [6] may facilitate migration and putative differentiation of inflammatory monocytes to inflammatory dendritic cells in this rat strain.…”

Section: Discussionmentioning

confidence: 99%

“…We have recently reported that peritoneal cavity cells from rats of Dark Agouti (DA) rat strain displayed more vigorous priming and inflammatory response upon intraperitoneal (i.p.) stimulation with own commensal E.coli and Enterococcus spp., compared to the cells from rats of Albino Oxford (AO) rat strain [6]. These non-MHC compatible rat strains substantially differ in their susceptibility to the induction of autoimmune diseases, DA rats being significantly more susceptible to experimental autoimmune encephalomyelitis and adjuvant arthritis [7,8].…”

Section: Introductionmentioning

confidence: 99%

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Lactobacillus rhamnosus Affects Rat Peritoneal Cavity Cell Response to Stimulation with Gut Microbiota: Focus on the Host Innate Immunity

et al. 2021

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Gut microbiota contribute to shaping the immune repertoire of the host, whereas probiotics may exert beneficial effects by modulating immune responses. Having in mind the differences in both the composition of gut microbiota and the immune response between rats of Albino Oxford (AO) and Dark Agouti (DA) rat strains, we investigated if intraperitoneal (i.p.) injection of live Lactobacillus rhamnosus (LB) may influence peritoneal cavity cell response to in vitro treatments with selected microbiota in the rat straindependent manner. Peritoneal cavity cells from AO and DA rats were lavaged two (d2) and seven days (d7) following i.p. injection with LB and tested for NO, urea, and H 2 O 2 release basally, or upon in vitro stimulation with autologous E.coli and Enterococcus spp. Whereas the single i.p. injection of LB nearly depleted resident macrophages and increased the proportion of small inflammatory macrophages and monocytes on d2 in both rat strains, greater proportion of MHCII hi CD163 − and CCR7 + cells and increased NO/diminished H 2 O 2 release in DA compared with AO rats suggest a more intense inflammatory priming by LB in this rat strain. Even though E.coli-and/or Enterococcus spp.-induced rise in H 2 O 2 release in vitro was abrogated by LB in cells from both rat strains, LB prevented microbiota-induced increase in NO/urea ratio only in cells from AO and augmented it in cells from DA rats. Thus, the immunomodulatory properties may not be constant for particular probiotic bacteria, but shaped by innate immunity of the host.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lactobacillus rhamnosus Affects Rat Peritoneal Cavity Cell Response to Stimulation with Gut Microbiota: Focus on the Host Innate Immunity

et al. 2021

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“…When autoimmune-prone Dark Agouti (DA) rats were intraperitoneally injected with their own colonic E . coli or Enterococcus for two days, the proportion of resident and anti-inflammatory macrophages was diminished, the proportion of activated neutrophils was increased, and the inflammatory polarization of peritoneal cells was induced [ 50 ]. Tanoue et al reported that a consortium of 11 bacterial strains isolated from healthy human donor faeces could induce IFN- γ -producing CD8 + T cells without causing inflammation in the intestine [ 51 ].…”

Section: Interactions Of the Gut Microbiota And Metabolites With Imentioning

confidence: 99%

Interactions between Gut Microbiota and Immunomodulatory Cells in Rheumatoid Arthritis

Zhao

Fan

et al. 2020

Mediators of Inflammation

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Rheumatoid arthritis (RA) is one of the most common autoimmune diseases caused by abnormal immune activation and immune tolerance. Immunomodulatory cells (ICs) play a critical role in the maintenance and homeostasis of normal immune function and in the pathogenesis of RA. The human gastrointestinal tract is inhabited by trillions of commensal microbiota on the mucosal surface that play a fundamental role in the induction, maintenance, and function of the host immune system. Gut microbiota dysbiosis can impact both the local and systemic immune systems and further contribute to various diseases, such as RA. The neighbouring intestinal ICs located in distinct intestinal mucosa may be the most likely intermediary by which the gut microbiota can affect the occurrence and development of RA. However, the reciprocal interaction between the components of the gut microbiota and their microbial metabolites with distinct ICs and how this interaction may impact the development of RA are not well studied. Therefore, a better understanding of the gut microbiota, ICs, and their interactions might improve our knowledge of the mechanisms by which the gut microbiota contribute to RA and facilitate the further development of novel therapeutic approaches. In this review, we have summarized the roles of the gut microbiota in the immunopathogenesis of RA, especially the interactions between the gut microbiota and ICs, and further discussed the strategies for treating RA by targeting/regulating the gut microbiota.

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“…Immunological responses both locally and systematically, as well as the interaction with the resident microflora of the host, are key factors in the pathobiology of gastrointestinal mucositis [25]. Unfortunately, they too differ amongst species [26][27][28]. When considering this in combination with the highly heterogenous landscape of supportive oncology, the difficulties in translating preclinical findings for mucositis interventions are not surprising.…”

Section: Gastrointestinal Mucositismentioning

confidence: 99%

Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets

Wardill

Tissing

Kissow

et al. 2019

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of review: Mucositis remains a prevalent, yet poorly managed side effect of anticancer therapies. Mucositis affecting both the oral cavity and gastrointestinal tract predispose to infection and require extensive supportive management, contributing to the growing economic burden associated with cancer care. Animal models remain a critical aspect of mucositis research, providing novel insights into its pathogenesis and revealing therapeutic targets. The current review aims to provide a comprehensive overview of the current animal models used in mucositis research. Recent findings: A wide variety of animal models of mucositis exist highlighting the highly heterogenous landscape of supportive oncology and the unique cytotoxic mechanisms of different anticancer agents. Golden Syrian hamsters remain the gold-standard species for investigation of oral mucositis induced by single-dose and fractionated radiation as well as chemoradiation. There is no universally accepted gold-standard model for the study of gastrointestinal mucositis, with rats, mice, pigs and dogs all offering unique perspectives on its pathobiology. Summary: Animal models are a critical aspect of mucositis research, providing unprecedent insight into the pathobiology of mucositis. Introduction of tumour-bearing models, cyclic dosing scheduled, concomitant agents and genetically modified animals have been integral in refining our understanding of mucositis.

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Rat strain differences in peritoneal immune cell response to selected gut microbiota: A crossroad between tolerance and autoimmunity?

Cited by 6 publications

References 61 publications

Lactobacillus rhamnosus Affects Rat Peritoneal Cavity Cell Response to Stimulation with Gut Microbiota: Focus on the Host Innate Immunity

Lactobacillus rhamnosus Affects Rat Peritoneal Cavity Cell Response to Stimulation with Gut Microbiota: Focus on the Host Innate Immunity

Interactions between Gut Microbiota and Immunomodulatory Cells in Rheumatoid Arthritis

Animal models of mucositis: critical tools for advancing pathobiological understanding and identifying therapeutic targets

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