Rat small intestinal morphology and tissue regulatory peptides: effects of high dietary fat

F, Sagher; Dodge, J A; Johnston, C.F.; Shaw, Christopher; Buchanan, K. D.; Carr, K. E.

doi:10.1079/bjn19910062

Cited by 48 publications

(30 citation statements)

References 26 publications

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“…In our experimental model, mice chronically fed a HFD showed changes in some morphometric parameters, consistent with the results of the previous studies (Sagher et al 1991, Thomson et al 1996, Scoaris et al 2010, De Barros Alencar et al 2012, which were similar in duodenal and jejunal segments. Indeed, we cannot establish whether the effects observed are specifically induced by the fat or by the different caloric intake.…”

Section: Discussionsupporting

confidence: 81%

“…Moreover, morphological alterations of rat small intestine including hypertrophy, increase in the villus height, and increase in the number of enterocytes per villus have been observed in response to dietary fat adaptation (Sagher et al 1991, Thomson et al 1996. However, a potential role of GLP2 in mediating the mucosal responses to a HFD has not been considered yet.…”

Section: Introductionmentioning

confidence: 99%

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Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet

Baldassano¹,

Amato²,

Cappello³

et al. 2013

Journal of Endocrinology

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Endogenous glucagon-like peptide-2 (GLP2) is a key mediator of refeeding-induced and resection-induced intestinal adaptive growth. This study investigated the potential role of GLP2 in mediating the mucosal responses to a chronic high-fat diet (HFD). In this view, the murine small intestine adaptive response to a HFD was analyzed and a possible involvement of endogenous GLP2 was verified using GLP2 (3-33) as GLP2 receptor (GLP2R) antagonist. In comparison with animals fed a standard diet, mice fed a HFD for 14 weeks exhibited an increase in crypt-villus mean height (duodenum, 27.5G3.0%; jejunum, 36.5G2.9%; P!0.01), in the cell number per villus (duodenum, 28.4G2.2%; jejunum, 32.0G2.9%; P!0.01), and in Ki67-positive cell number per crypt. No change in the percent of caspase-3-positive cell in the villus-crypt was observed. The chronic exposure to a HFD also caused a significant increase in GLP2 plasma levels and in GLP2R intestinal expression. Daily administration of GLP2 (3-33) (30-60 ng) for 4 weeks did not modify the crypt-villus height in control mice. In HFD-fed mice, chronic treatment with GLP2 (3-33) reduced the increase in crypt-villus height and in the cell number per villus through reduction of cell proliferation and increase in apoptosis. This study provides the first experimental evidence for a role of endogenous GLP2 in the intestinal adaptation to HFD in obese mice and for a dysregulation of the GLP2/GLP2R system after a prolonged HFD.

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Section: Discussionsupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet

Baldassano¹,

Amato²,

Cappello³

et al. 2013

Journal of Endocrinology

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“…It has been reported that rats fed a diet high in polyunsaturated fat had both the tallest villi [17] and the best absorp tion [ 18]. The ileal absorptive cells of the mice fed the pectin diet contained numerous perox isomes, whereas there were few in the same cells of those fed the cellulose diet.…”

Section: Discussionmentioning

confidence: 98%

Effects of Pectin on Jejunal and Heal Morphology and Ultrastructure in Adult Mice

Tamura¹,

Suzuki²

1997

Ann Nutr Metab

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The effects of pectin on jejunal and ileal morphology and ultrastructure were studied using adult male mice fed a semisynthetic diet containing 8% (w/w) cellulose or pectin for 30 days. No significant differences in the jejunal villus height between the 2 groups were found, but the jejunal crypt depth, and both the ileal villus height and crypt depth of the mice fed the pectin diet were significantly greater than those of the mice fed the cellulose diet. There were evident ultrastructural differences in the jejunal absorptive cells between 2 dietary groups: numerous intercellular spaces were observed in the jejunal absorptive cells of the mice fed the pectin diet, but not the cellulose diet. Moreover, the ileal absorptive cells of the mice fed the pectin diet contained numerous peroxisomes, whereas there were few in these cells of mice fed the cellulose diet. The functional characteristics of the ileum of the mice fed the pectin diet might be different from those fed the cellulose diet.

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“…In rats, exposure to a high-fat diet for 1 (16), 2 (18), or 8 (17) wk increases intestinal villus height (17) and pancreatic lipase secretion (17,18). A high-fat diet also attenuates the inhibition of gastric emptying and food intake in response to the intraduodenal administration of fat (10 -12).…”

Section: Introductionmentioning

confidence: 99%

Effect of different macronutrients in excess on gastric sensory and motor functions and appetite in normal-weight, overweight, and obese humans

Park

Camilleri

O’Connor

et al. 2007

The American Journal of Clinical Nutrition

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Background: The effects of supplementation with different macronutrients on gastric sensory and motor functions are unclear. Objective: We aimed to compare the effects of 2 wk of supplementation with different classes of macronutrients on gastric function, satiation, and appetite in healthy and overweight subjects. Design: In a parallel-group, double-blind study, 52 (14 men, 38 women) healthy normal-weight, overweight, and obese participants [body mass index (BMI; in kg/m 2 ): 19.4 -47.0] aged 18 -64 y were randomly assigned to consume different isocaloric diets (n ҃ 13 per diet group) adjusted for BMI and activity level. The standard diet provided 20% of energy as protein, 30% as fat, and 50% as carbohydrate. The high-protein, high-fat, and high-carbohydrate diets contained 500 additional kcal in each nutrient class. On 3 separate days, we measured gastric emptying of solids, gastric volumes, postprandial symptoms, appetite, and food choice with validated methods. Age, sex, BMI, and baseline satiation were covariates in the analysis of covariance. Results: Fat supplementation was associated with increased maximum tolerated volume (MTV) in subjects with a high baseline MTV (P 0.05), irrespective of BMI. Gastric emptying and volumes, postprandial symptoms, total calories, and food choices at an ad libitum meal were not significantly different after each dietary preload. Fasting gastric volumes tended to be higher with the high-fat than with the high-carbohydrate or high-protein diets (P ͨ 0.1). Gastric emptying and volumes and satiation were not significantly different between the BMI categories ( and 30). Conclusion: Supplementation with 500 kcal fat in excess of required calories for 2 wk increased food tolerance in healthy normalweight and obese subjects with a high baseline MTV without significantly changing gastric motor functions.Am J Clin Nutr 2007;85:411-8.

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Rat small intestinal morphology and tissue regulatory peptides: effects of high dietary fat

Cited by 48 publications

References 26 publications

Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet

Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet

Effects of Pectin on Jejunal and Heal Morphology and Ultrastructure in Adult Mice

Effect of different macronutrients in excess on gastric sensory and motor functions and appetite in normal-weight, overweight, and obese humans

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